VEGF and CD31 association in pituitary adenomas

Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular endothelial growth factor (VEGF) by immunohistochemistry has yielded controvers...

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Publicado:	2010
Materias:	Angiogenesis CD31 Pelioisis Pituitary adenoma Proliferation VEGF CD31 antigen cycline Ki 67 antigen vasculotropin adult age angiogenesis article carcinogenesis cell proliferation correlation analysis disease course epithelium cell female gender growth hormone secreting adenoma histopathology human human tissue hypophysis adenoma major clinical study male mutation priority journal prolactinoma protein expression tumor growth Western blotting Adenoma Adult Antigens, CD31 Blotting, Western Female Humans Male Pituitary Neoplasms Tumor Markers, Biological Vascular Endothelial Growth Factor A
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10463976_v21_n3_p154_Cristina http://hdl.handle.net/20.500.12110/paper_10463976_v21_n3_p154_Cristina
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10463976_v21_n3_p154_Cristina
record_format	dspace
spelling	paper:paper_10463976_v21_n3_p154_Cristina2023-06-08T16:01:13Z VEGF and CD31 association in pituitary adenomas Angiogenesis CD31 Pelioisis Pituitary adenoma Proliferation VEGF CD31 antigen cycline Ki 67 antigen vasculotropin adult age angiogenesis article carcinogenesis cell proliferation correlation analysis disease course epithelium cell female gender growth hormone secreting adenoma histopathology human human tissue hypophysis adenoma major clinical study male mutation priority journal prolactinoma protein expression tumor growth Western blotting Adenoma Adult Antigens, CD31 Blotting, Western Female Humans Male Pituitary Neoplasms Tumor Markers, Biological Vascular Endothelial Growth Factor A Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular endothelial growth factor (VEGF) by immunohistochemistry has yielded controversial results, as a broad spectrum of immunostaining can be found. We determined the protein expression of VEGF and CD31, an endothelial marker, in a series of 56 surgically removed pituitary adenomas using Western blot assay. Prolactinomas had higher VEGF protein expression compared to nonfunctioning or ACTH- and GH-secreting adenomas, while CD31 was similar in the different adenoma histotypes. VEGF and CD31 were not affected by sex, age, years of adenoma evolution, or proliferation rate (Ki67 and PCNA) for all adenoma types. Only in nonfunctioning adenomas CD31 concentration increased significantly with age. There was a positive correlation between CD31 and VEGF expression when all adenoma histotypes were considered, or when prolactinomas and nonfunctioning adenomas were evaluated separately. The positive association of VEGF and CD31 expression suggests the participation of angiogenesis in adenoma development, while epithelial cell proliferation in pituitary tumors is not directly related to VEGF or CD31 expression, and other factors, such as primary genetic alterations may be involved. © 2010 Springer Science+Business Media, LLC. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10463976_v21_n3_p154_Cristina http://hdl.handle.net/20.500.12110/paper_10463976_v21_n3_p154_Cristina
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiogenesis CD31 Pelioisis Pituitary adenoma Proliferation VEGF CD31 antigen cycline Ki 67 antigen vasculotropin adult age angiogenesis article carcinogenesis cell proliferation correlation analysis disease course epithelium cell female gender growth hormone secreting adenoma histopathology human human tissue hypophysis adenoma major clinical study male mutation priority journal prolactinoma protein expression tumor growth Western blotting Adenoma Adult Antigens, CD31 Blotting, Western Female Humans Male Pituitary Neoplasms Tumor Markers, Biological Vascular Endothelial Growth Factor A
spellingShingle	Angiogenesis CD31 Pelioisis Pituitary adenoma Proliferation VEGF CD31 antigen cycline Ki 67 antigen vasculotropin adult age angiogenesis article carcinogenesis cell proliferation correlation analysis disease course epithelium cell female gender growth hormone secreting adenoma histopathology human human tissue hypophysis adenoma major clinical study male mutation priority journal prolactinoma protein expression tumor growth Western blotting Adenoma Adult Antigens, CD31 Blotting, Western Female Humans Male Pituitary Neoplasms Tumor Markers, Biological Vascular Endothelial Growth Factor A VEGF and CD31 association in pituitary adenomas
topic_facet	Angiogenesis CD31 Pelioisis Pituitary adenoma Proliferation VEGF CD31 antigen cycline Ki 67 antigen vasculotropin adult age angiogenesis article carcinogenesis cell proliferation correlation analysis disease course epithelium cell female gender growth hormone secreting adenoma histopathology human human tissue hypophysis adenoma major clinical study male mutation priority journal prolactinoma protein expression tumor growth Western blotting Adenoma Adult Antigens, CD31 Blotting, Western Female Humans Male Pituitary Neoplasms Tumor Markers, Biological Vascular Endothelial Growth Factor A
description	Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular endothelial growth factor (VEGF) by immunohistochemistry has yielded controversial results, as a broad spectrum of immunostaining can be found. We determined the protein expression of VEGF and CD31, an endothelial marker, in a series of 56 surgically removed pituitary adenomas using Western blot assay. Prolactinomas had higher VEGF protein expression compared to nonfunctioning or ACTH- and GH-secreting adenomas, while CD31 was similar in the different adenoma histotypes. VEGF and CD31 were not affected by sex, age, years of adenoma evolution, or proliferation rate (Ki67 and PCNA) for all adenoma types. Only in nonfunctioning adenomas CD31 concentration increased significantly with age. There was a positive correlation between CD31 and VEGF expression when all adenoma histotypes were considered, or when prolactinomas and nonfunctioning adenomas were evaluated separately. The positive association of VEGF and CD31 expression suggests the participation of angiogenesis in adenoma development, while epithelial cell proliferation in pituitary tumors is not directly related to VEGF or CD31 expression, and other factors, such as primary genetic alterations may be involved. © 2010 Springer Science+Business Media, LLC.
title	VEGF and CD31 association in pituitary adenomas
title_short	VEGF and CD31 association in pituitary adenomas
title_full	VEGF and CD31 association in pituitary adenomas
title_fullStr	VEGF and CD31 association in pituitary adenomas
title_full_unstemmed	VEGF and CD31 association in pituitary adenomas
title_sort	vegf and cd31 association in pituitary adenomas
publishDate	2010
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10463976_v21_n3_p154_Cristina http://hdl.handle.net/20.500.12110/paper_10463976_v21_n3_p154_Cristina
_version_	1768541715111608320

VEGF and CD31 association in pituitary adenomas

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