FKBP51 and FKBP52 in signaling and disease
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10432760_v22_n12_p481_Storer http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p481_Storer |
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paper:paper_10432760_v22_n12_p481_Storer2023-06-08T16:01:00Z FKBP51 and FKBP52 in signaling and disease androgen receptor antineoplastic agent doxorubicin estrogen receptor immunoglobulin enhancer binding protein mineralocorticoid receptor multiprotein complex progesterone receptor protein FKBP51 protein FKBP52 protein kinase B receptor chaperone complex regulator protein steroid hormone steroid receptor tacrolimus unclassified drug Alzheimer disease anxiety disorder bipolar disorder breast carcinogenesis breast tumor cell proliferation cellular distribution complex formation depression disease association drug targeting genital system human immune system immunopathology mental stress metabolic disorder molecular pathology neuropathology nonhuman pathophysiology posttraumatic stress disorder priority journal prostate cancer protein conformation protein folding protein function protein localization protein protein interaction protein structure review schizophrenia signal transduction tauopathy Alzheimer Disease Animals Humans Molecular Chaperones Molecular Targeted Therapy Neoplasms Protein Transport Receptors, Steroid Signal Transduction Stress, Psychological Tacrolimus Binding Proteins FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich loop. FKBP51 and FKBP52 have emerged as likely contributors to a variety of hormone-dependent diseases, including stress-related diseases, immune function, reproductive functions and a variety of cancers. In addition, recent studies have implicated FKBP51 and FKBP52 in Alzheimer's disease and other protein aggregation disorders. This review summarizes our current understanding of FKBP51 and FKBP52 interactions within the receptor-chaperone complex, their contributions to health and disease, and their potential as therapeutic targets for the treatment of thesediseases. © 2011 Elsevier Ltd. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10432760_v22_n12_p481_Storer http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p481_Storer |
| institution |
Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
androgen receptor antineoplastic agent doxorubicin estrogen receptor immunoglobulin enhancer binding protein mineralocorticoid receptor multiprotein complex progesterone receptor protein FKBP51 protein FKBP52 protein kinase B receptor chaperone complex regulator protein steroid hormone steroid receptor tacrolimus unclassified drug Alzheimer disease anxiety disorder bipolar disorder breast carcinogenesis breast tumor cell proliferation cellular distribution complex formation depression disease association drug targeting genital system human immune system immunopathology mental stress metabolic disorder molecular pathology neuropathology nonhuman pathophysiology posttraumatic stress disorder priority journal prostate cancer protein conformation protein folding protein function protein localization protein protein interaction protein structure review schizophrenia signal transduction tauopathy Alzheimer Disease Animals Humans Molecular Chaperones Molecular Targeted Therapy Neoplasms Protein Transport Receptors, Steroid Signal Transduction Stress, Psychological Tacrolimus Binding Proteins |
| spellingShingle |
androgen receptor antineoplastic agent doxorubicin estrogen receptor immunoglobulin enhancer binding protein mineralocorticoid receptor multiprotein complex progesterone receptor protein FKBP51 protein FKBP52 protein kinase B receptor chaperone complex regulator protein steroid hormone steroid receptor tacrolimus unclassified drug Alzheimer disease anxiety disorder bipolar disorder breast carcinogenesis breast tumor cell proliferation cellular distribution complex formation depression disease association drug targeting genital system human immune system immunopathology mental stress metabolic disorder molecular pathology neuropathology nonhuman pathophysiology posttraumatic stress disorder priority journal prostate cancer protein conformation protein folding protein function protein localization protein protein interaction protein structure review schizophrenia signal transduction tauopathy Alzheimer Disease Animals Humans Molecular Chaperones Molecular Targeted Therapy Neoplasms Protein Transport Receptors, Steroid Signal Transduction Stress, Psychological Tacrolimus Binding Proteins FKBP51 and FKBP52 in signaling and disease |
| topic_facet |
androgen receptor antineoplastic agent doxorubicin estrogen receptor immunoglobulin enhancer binding protein mineralocorticoid receptor multiprotein complex progesterone receptor protein FKBP51 protein FKBP52 protein kinase B receptor chaperone complex regulator protein steroid hormone steroid receptor tacrolimus unclassified drug Alzheimer disease anxiety disorder bipolar disorder breast carcinogenesis breast tumor cell proliferation cellular distribution complex formation depression disease association drug targeting genital system human immune system immunopathology mental stress metabolic disorder molecular pathology neuropathology nonhuman pathophysiology posttraumatic stress disorder priority journal prostate cancer protein conformation protein folding protein function protein localization protein protein interaction protein structure review schizophrenia signal transduction tauopathy Alzheimer Disease Animals Humans Molecular Chaperones Molecular Targeted Therapy Neoplasms Protein Transport Receptors, Steroid Signal Transduction Stress, Psychological Tacrolimus Binding Proteins |
| description |
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich loop. FKBP51 and FKBP52 have emerged as likely contributors to a variety of hormone-dependent diseases, including stress-related diseases, immune function, reproductive functions and a variety of cancers. In addition, recent studies have implicated FKBP51 and FKBP52 in Alzheimer's disease and other protein aggregation disorders. This review summarizes our current understanding of FKBP51 and FKBP52 interactions within the receptor-chaperone complex, their contributions to health and disease, and their potential as therapeutic targets for the treatment of thesediseases. © 2011 Elsevier Ltd. |
| title |
FKBP51 and FKBP52 in signaling and disease |
| title_short |
FKBP51 and FKBP52 in signaling and disease |
| title_full |
FKBP51 and FKBP52 in signaling and disease |
| title_fullStr |
FKBP51 and FKBP52 in signaling and disease |
| title_full_unstemmed |
FKBP51 and FKBP52 in signaling and disease |
| title_sort |
fkbp51 and fkbp52 in signaling and disease |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10432760_v22_n12_p481_Storer http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p481_Storer |
| _version_ |
1768544190727192576 |