Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their rel...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1040452X_v79_n1_p4_Buffone http://hdl.handle.net/20.500.12110/paper_1040452X_v79_n1_p4_Buffone |
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paper:paper_1040452X_v79_n1_p4_Buffone2023-06-08T16:00:46Z Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility 2 arachidonoylglycerol A kinase anchoring protein 3 A kinase anchoring protein 4 adenosine triphosphate adenosine triphosphate sensitive potassium channel adenylate cyclase adenylate cyclase 2 adenylate cyclase 3 adenylate cyclase 8 anandamide calcium cannabinoid 1 receptor cation channel cell protein chloride channel CRISP1 protein cyclic AMP cyclic AMP dependent protein kinase anchoring protein forskolin glyceraldehyde 3 phosphate dehydrogenase glyceraldehyde 3 phosphate dehydrogenase S glycogen synthase kinase 3 inwardly rectifying potassium channel subunit Kir6.1 inwardly rectifying potassium channel subunit Kir6.2 phosphoglycerate kinase phosphoglycerate kinase 2 proton SLC9A10 protein sperm associated cation channel 1 unclassified drug ZP3R protein acrosomal exocytosis acrosome reaction actin polymerization alkalinization cell nucleus membrane cell swelling cellular distribution depolymerization disulfide bond epididymis exocytosis fertilization glycolysis human hyperpolarization nonhuman pH potassium current priority journal protein expression protein localization protein phosphorylation review spermatid spermatogenesis spermatozoon capacitation spermatozoon maturation spermatozoon motility spermatozoon tail Acrosome Acrosome Reaction Animals Female Humans Male Mice Models, Biological Ovum Sperm Capacitation Sperm Motility Sperm Tail Spermatozoa Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems. © 2011 Wiley Periodicals, Inc. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1040452X_v79_n1_p4_Buffone http://hdl.handle.net/20.500.12110/paper_1040452X_v79_n1_p4_Buffone |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2 arachidonoylglycerol A kinase anchoring protein 3 A kinase anchoring protein 4 adenosine triphosphate adenosine triphosphate sensitive potassium channel adenylate cyclase adenylate cyclase 2 adenylate cyclase 3 adenylate cyclase 8 anandamide calcium cannabinoid 1 receptor cation channel cell protein chloride channel CRISP1 protein cyclic AMP cyclic AMP dependent protein kinase anchoring protein forskolin glyceraldehyde 3 phosphate dehydrogenase glyceraldehyde 3 phosphate dehydrogenase S glycogen synthase kinase 3 inwardly rectifying potassium channel subunit Kir6.1 inwardly rectifying potassium channel subunit Kir6.2 phosphoglycerate kinase phosphoglycerate kinase 2 proton SLC9A10 protein sperm associated cation channel 1 unclassified drug ZP3R protein acrosomal exocytosis acrosome reaction actin polymerization alkalinization cell nucleus membrane cell swelling cellular distribution depolymerization disulfide bond epididymis exocytosis fertilization glycolysis human hyperpolarization nonhuman pH potassium current priority journal protein expression protein localization protein phosphorylation review spermatid spermatogenesis spermatozoon capacitation spermatozoon maturation spermatozoon motility spermatozoon tail Acrosome Acrosome Reaction Animals Female Humans Male Mice Models, Biological Ovum Sperm Capacitation Sperm Motility Sperm Tail Spermatozoa |
| spellingShingle |
2 arachidonoylglycerol A kinase anchoring protein 3 A kinase anchoring protein 4 adenosine triphosphate adenosine triphosphate sensitive potassium channel adenylate cyclase adenylate cyclase 2 adenylate cyclase 3 adenylate cyclase 8 anandamide calcium cannabinoid 1 receptor cation channel cell protein chloride channel CRISP1 protein cyclic AMP cyclic AMP dependent protein kinase anchoring protein forskolin glyceraldehyde 3 phosphate dehydrogenase glyceraldehyde 3 phosphate dehydrogenase S glycogen synthase kinase 3 inwardly rectifying potassium channel subunit Kir6.1 inwardly rectifying potassium channel subunit Kir6.2 phosphoglycerate kinase phosphoglycerate kinase 2 proton SLC9A10 protein sperm associated cation channel 1 unclassified drug ZP3R protein acrosomal exocytosis acrosome reaction actin polymerization alkalinization cell nucleus membrane cell swelling cellular distribution depolymerization disulfide bond epididymis exocytosis fertilization glycolysis human hyperpolarization nonhuman pH potassium current priority journal protein expression protein localization protein phosphorylation review spermatid spermatogenesis spermatozoon capacitation spermatozoon maturation spermatozoon motility spermatozoon tail Acrosome Acrosome Reaction Animals Female Humans Male Mice Models, Biological Ovum Sperm Capacitation Sperm Motility Sperm Tail Spermatozoa Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| topic_facet |
2 arachidonoylglycerol A kinase anchoring protein 3 A kinase anchoring protein 4 adenosine triphosphate adenosine triphosphate sensitive potassium channel adenylate cyclase adenylate cyclase 2 adenylate cyclase 3 adenylate cyclase 8 anandamide calcium cannabinoid 1 receptor cation channel cell protein chloride channel CRISP1 protein cyclic AMP cyclic AMP dependent protein kinase anchoring protein forskolin glyceraldehyde 3 phosphate dehydrogenase glyceraldehyde 3 phosphate dehydrogenase S glycogen synthase kinase 3 inwardly rectifying potassium channel subunit Kir6.1 inwardly rectifying potassium channel subunit Kir6.2 phosphoglycerate kinase phosphoglycerate kinase 2 proton SLC9A10 protein sperm associated cation channel 1 unclassified drug ZP3R protein acrosomal exocytosis acrosome reaction actin polymerization alkalinization cell nucleus membrane cell swelling cellular distribution depolymerization disulfide bond epididymis exocytosis fertilization glycolysis human hyperpolarization nonhuman pH potassium current priority journal protein expression protein localization protein phosphorylation review spermatid spermatogenesis spermatozoon capacitation spermatozoon maturation spermatozoon motility spermatozoon tail Acrosome Acrosome Reaction Animals Female Humans Male Mice Models, Biological Ovum Sperm Capacitation Sperm Motility Sperm Tail Spermatozoa |
| description |
Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems. © 2011 Wiley Periodicals, Inc. |
| title |
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| title_short |
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| title_full |
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| title_fullStr |
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| title_full_unstemmed |
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| title_sort |
heads or tails? structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1040452X_v79_n1_p4_Buffone http://hdl.handle.net/20.500.12110/paper_1040452X_v79_n1_p4_Buffone |
| _version_ |
1768545200437723136 |