Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice
Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a wor...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10253890_v12_n2_p134_Frick http://hdl.handle.net/20.500.12110/paper_10253890_v12_n2_p134_Frick |
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paper:paper_10253890_v12_n2_p134_Frick2023-06-08T16:00:14Z Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice Cancer CD4/CD8 Chronic stress Cytokines T-cell immunity Tumor growth gamma interferon tumor necrosis factor alpha animal cell animal experiment animal model article behavior change CD4+ T lymphocyte CD8+ T lymphocyte cellular immunity chronic stress controlled study cytokine production cytotoxicity female immobilization stress lymphocyte proliferation mouse natural killer cell nonhuman priority journal spleen cell T cell lymphoma tumor growth Animals Behavior, Animal CD4-Positive T-Lymphocytes Cell Proliferation Female Interferon-gamma Killer Cells, Natural Lymphoma, T-Cell Mice Mice, Inbred BALB C Restraint, Physical Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4+T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival. Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the therapeutic management of stress to improve the prognosis of cancer patients. © Informa Healthcare USA, Inc. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10253890_v12_n2_p134_Frick http://hdl.handle.net/20.500.12110/paper_10253890_v12_n2_p134_Frick |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cancer CD4/CD8 Chronic stress Cytokines T-cell immunity Tumor growth gamma interferon tumor necrosis factor alpha animal cell animal experiment animal model article behavior change CD4+ T lymphocyte CD8+ T lymphocyte cellular immunity chronic stress controlled study cytokine production cytotoxicity female immobilization stress lymphocyte proliferation mouse natural killer cell nonhuman priority journal spleen cell T cell lymphoma tumor growth Animals Behavior, Animal CD4-Positive T-Lymphocytes Cell Proliferation Female Interferon-gamma Killer Cells, Natural Lymphoma, T-Cell Mice Mice, Inbred BALB C Restraint, Physical Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha |
| spellingShingle |
Cancer CD4/CD8 Chronic stress Cytokines T-cell immunity Tumor growth gamma interferon tumor necrosis factor alpha animal cell animal experiment animal model article behavior change CD4+ T lymphocyte CD8+ T lymphocyte cellular immunity chronic stress controlled study cytokine production cytotoxicity female immobilization stress lymphocyte proliferation mouse natural killer cell nonhuman priority journal spleen cell T cell lymphoma tumor growth Animals Behavior, Animal CD4-Positive T-Lymphocytes Cell Proliferation Female Interferon-gamma Killer Cells, Natural Lymphoma, T-Cell Mice Mice, Inbred BALB C Restraint, Physical Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| topic_facet |
Cancer CD4/CD8 Chronic stress Cytokines T-cell immunity Tumor growth gamma interferon tumor necrosis factor alpha animal cell animal experiment animal model article behavior change CD4+ T lymphocyte CD8+ T lymphocyte cellular immunity chronic stress controlled study cytokine production cytotoxicity female immobilization stress lymphocyte proliferation mouse natural killer cell nonhuman priority journal spleen cell T cell lymphoma tumor growth Animals Behavior, Animal CD4-Positive T-Lymphocytes Cell Proliferation Female Interferon-gamma Killer Cells, Natural Lymphoma, T-Cell Mice Mice, Inbred BALB C Restraint, Physical Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha |
| description |
Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4+T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival. Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the therapeutic management of stress to improve the prognosis of cancer patients. © Informa Healthcare USA, Inc. |
| title |
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| title_short |
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| title_full |
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| title_fullStr |
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| title_full_unstemmed |
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice |
| title_sort |
chronic restraint stress impairs t-cell immunity and promotes tumor progression in mice |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10253890_v12_n2_p134_Frick http://hdl.handle.net/20.500.12110/paper_10253890_v12_n2_p134_Frick |
| _version_ |
1768542997879717888 |