Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation
Neuroimmune-endocrine interactions seem to be central to the dialogue between the mother and the growing embryo during normal pregnancy. A proinflammatory Th1 microenvironment appears to be associated with embryo implantation but an excess of these cytokines may be deleterious. When normal gestation...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v15_n1_p84_Larocca http://hdl.handle.net/20.500.12110/paper_10217401_v15_n1_p84_Larocca |
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paper:paper_10217401_v15_n1_p84_Larocca2023-06-08T16:00:01Z Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation Larocca, Luciana Ramhorst, Rosanna Elizabeth Roca, Valeria Inés Calafat, Mario José Aisemberg, Julieta Franchi, Ana María Pérez Leirós, Claudia Autoimmune diseases, chronic Macrophages Neuroimmune regulation Pregnancy catecholamine estrogen estrogen receptor beta glucocorticoid receptor hydrocortisone interleukin 1 interleukin 10 interleukin 12 interleukin 6 leukemia inhibitory factor receptor lipopolysaccharide progesterone prolactin receptor tumor necrosis factor alpha adaptive immunity autoimmune disease cell activation cellular immunity disease course embryo development endocrine function first trimester pregnancy gestation period hormonal regulation human immunoregulation innate immunity macrophage activation maternal stress mother fetus relationship nidation nonhuman priority journal review Th1 cell Th2 cell Animals Autoimmune Diseases Embryo Implantation Female Humans Immune Tolerance Inflammation Macrophage Activation Macrophages Maternal-Fetal Exchange Neuroimmunomodulation Neurosecretory Systems Pregnancy Pregnancy Complications Th1 Cells Neuroimmune-endocrine interactions seem to be central to the dialogue between the mother and the growing embryo during normal pregnancy. A proinflammatory Th1 microenvironment appears to be associated with embryo implantation but an excess of these cytokines may be deleterious. When normal gestation is subjected to stressful stimuli as those provided by a chronic inflammatory milieu, the activation profile of T cells and macrophages may be temporarily changed. Although much evidence supports the protective role of pregnancy in Th1 autoimmune diseases, the comprehension of the maternofetal interaction in an inflammatory context may serve to get more insight into pregnancy failures. Macrophages integrate multiple inputs and signals of neuroimmune-endocrine systems and they appear as major participants in either embryo implantation or loss. Changes at the macrophage level during gestation might help to understand their regulatory role in embryo implantation as well as to disclose their local and systemic pathogenic potential. Copyright © 2008 S. Karger AG. Fil:Larocca, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramhorst, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Roca, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calafat, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Aisemberg, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Franchi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pérez Leirós, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v15_n1_p84_Larocca http://hdl.handle.net/20.500.12110/paper_10217401_v15_n1_p84_Larocca |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autoimmune diseases, chronic Macrophages Neuroimmune regulation Pregnancy catecholamine estrogen estrogen receptor beta glucocorticoid receptor hydrocortisone interleukin 1 interleukin 10 interleukin 12 interleukin 6 leukemia inhibitory factor receptor lipopolysaccharide progesterone prolactin receptor tumor necrosis factor alpha adaptive immunity autoimmune disease cell activation cellular immunity disease course embryo development endocrine function first trimester pregnancy gestation period hormonal regulation human immunoregulation innate immunity macrophage activation maternal stress mother fetus relationship nidation nonhuman priority journal review Th1 cell Th2 cell Animals Autoimmune Diseases Embryo Implantation Female Humans Immune Tolerance Inflammation Macrophage Activation Macrophages Maternal-Fetal Exchange Neuroimmunomodulation Neurosecretory Systems Pregnancy Pregnancy Complications Th1 Cells |
| spellingShingle |
Autoimmune diseases, chronic Macrophages Neuroimmune regulation Pregnancy catecholamine estrogen estrogen receptor beta glucocorticoid receptor hydrocortisone interleukin 1 interleukin 10 interleukin 12 interleukin 6 leukemia inhibitory factor receptor lipopolysaccharide progesterone prolactin receptor tumor necrosis factor alpha adaptive immunity autoimmune disease cell activation cellular immunity disease course embryo development endocrine function first trimester pregnancy gestation period hormonal regulation human immunoregulation innate immunity macrophage activation maternal stress mother fetus relationship nidation nonhuman priority journal review Th1 cell Th2 cell Animals Autoimmune Diseases Embryo Implantation Female Humans Immune Tolerance Inflammation Macrophage Activation Macrophages Maternal-Fetal Exchange Neuroimmunomodulation Neurosecretory Systems Pregnancy Pregnancy Complications Th1 Cells Larocca, Luciana Ramhorst, Rosanna Elizabeth Roca, Valeria Inés Calafat, Mario José Aisemberg, Julieta Franchi, Ana María Pérez Leirós, Claudia Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| topic_facet |
Autoimmune diseases, chronic Macrophages Neuroimmune regulation Pregnancy catecholamine estrogen estrogen receptor beta glucocorticoid receptor hydrocortisone interleukin 1 interleukin 10 interleukin 12 interleukin 6 leukemia inhibitory factor receptor lipopolysaccharide progesterone prolactin receptor tumor necrosis factor alpha adaptive immunity autoimmune disease cell activation cellular immunity disease course embryo development endocrine function first trimester pregnancy gestation period hormonal regulation human immunoregulation innate immunity macrophage activation maternal stress mother fetus relationship nidation nonhuman priority journal review Th1 cell Th2 cell Animals Autoimmune Diseases Embryo Implantation Female Humans Immune Tolerance Inflammation Macrophage Activation Macrophages Maternal-Fetal Exchange Neuroimmunomodulation Neurosecretory Systems Pregnancy Pregnancy Complications Th1 Cells |
| description |
Neuroimmune-endocrine interactions seem to be central to the dialogue between the mother and the growing embryo during normal pregnancy. A proinflammatory Th1 microenvironment appears to be associated with embryo implantation but an excess of these cytokines may be deleterious. When normal gestation is subjected to stressful stimuli as those provided by a chronic inflammatory milieu, the activation profile of T cells and macrophages may be temporarily changed. Although much evidence supports the protective role of pregnancy in Th1 autoimmune diseases, the comprehension of the maternofetal interaction in an inflammatory context may serve to get more insight into pregnancy failures. Macrophages integrate multiple inputs and signals of neuroimmune-endocrine systems and they appear as major participants in either embryo implantation or loss. Changes at the macrophage level during gestation might help to understand their regulatory role in embryo implantation as well as to disclose their local and systemic pathogenic potential. Copyright © 2008 S. Karger AG. |
| author |
Larocca, Luciana Ramhorst, Rosanna Elizabeth Roca, Valeria Inés Calafat, Mario José Aisemberg, Julieta Franchi, Ana María Pérez Leirós, Claudia |
| author_facet |
Larocca, Luciana Ramhorst, Rosanna Elizabeth Roca, Valeria Inés Calafat, Mario José Aisemberg, Julieta Franchi, Ana María Pérez Leirós, Claudia |
| author_sort |
Larocca, Luciana |
| title |
Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| title_short |
Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| title_full |
Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| title_fullStr |
Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| title_full_unstemmed |
Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation |
| title_sort |
neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: focus on macrophage activation |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v15_n1_p84_Larocca http://hdl.handle.net/20.500.12110/paper_10217401_v15_n1_p84_Larocca |
| work_keys_str_mv |
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| _version_ |
1768542230161653760 |