NOD mice exocrinopathy: Towards a neuroimmune link

Sjögren's syndrome (SS) is a chronic autoimmune disorder of exocrine glands characterized as an autoimmune exocrinopathy and more specifically as an autoimmune epithelitis. An impaired balance of neuroimmune interactions mediated by vasoactive intestinal peptide (VIP) in the target organ at ear...

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Autores principales:	Calafat, Mario José, Larocca, Luciana, Roca, Valeria Inés, Pérez Leirós, Claudia
Publicado:	2007
Materias:	Apoptotic acinar cells Exocrinopathy Macrophages Neuroimmune Nitric oxide NOD mice gamma interferon interleukin 10 lipopolysaccharide nitric oxide nitrite vasoactive intestinal polypeptide acinar cell animal cell animal model apoptosis conference paper controlled study female macrophage mouse nonhuman nonobese diabetic mouse peritoneum macrophage priority journal Sjoegren syndrome stimulation submandibular gland Animals Apoptosis Cells, Cultured Disease Models, Animal Epithelial Cells Epithelium Female Inflammation Mediators Interferon Type II Interleukin-10 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Peritoneum Sjogren's Syndrome Submandibular Gland Vasoactive Intestinal Peptide
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v14_n3-4_p175_Calafat http://hdl.handle.net/20.500.12110/paper_10217401_v14_n3-4_p175_Calafat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10217401_v14_n3-4_p175_Calafat
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spelling	paper:paper_10217401_v14_n3-4_p175_Calafat2023-06-08T16:00:00Z NOD mice exocrinopathy: Towards a neuroimmune link Calafat, Mario José Larocca, Luciana Roca, Valeria Inés Pérez Leirós, Claudia Apoptotic acinar cells Exocrinopathy Macrophages Neuroimmune Nitric oxide NOD mice gamma interferon interleukin 10 lipopolysaccharide nitric oxide nitrite vasoactive intestinal polypeptide acinar cell animal cell animal model apoptosis conference paper controlled study female macrophage mouse nonhuman nonobese diabetic mouse peritoneum macrophage priority journal Sjoegren syndrome stimulation submandibular gland Animals Apoptosis Cells, Cultured Disease Models, Animal Epithelial Cells Epithelium Female Inflammation Mediators Interferon Type II Interleukin-10 Lipopolysaccharides Macrophages Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Peritoneum Sjogren's Syndrome Submandibular Gland Vasoactive Intestinal Peptide Sjögren's syndrome (SS) is a chronic autoimmune disorder of exocrine glands characterized as an autoimmune exocrinopathy and more specifically as an autoimmune epithelitis. An impaired balance of neuroimmune interactions mediated by vasoactive intestinal peptide (VIP) in the target organ at early stages of disease is explored by means of the nonobese diabetic (NOD) mouse model of SS. We have previously described a reduced salivary secretion and signaling upon VIP stimulation. The effect reflected a differential regulation of the neural isoform of nitric oxide synthase by calcium calmodulin kinase II and occurred prior to the appearance of detectable levels of cytokines in NOD glands. VIP acting on NOD macrophages treated with lipopolysaccharide promoted anti-inflammatory effects by inhibiting nitric oxide synthase induction as well as IL-12 and TNF-α production, while stimulating IL-10. Here we present evidence on the ability of apoptotic acinar cells from submandibular glands of NOD mice to stimulate nitric oxide in both peritoneal and glandular macrophage pools to a similar extent as lipopolysaccharide + IFN-γ. VIP was not effective to prevent nitrite accumulation and modestly increased IL-10 levels in macrophages coincubated with acinar cells. An enhanced nitrite response of NOD glandular macrophages in basal and stimulated conditions compared to peritoneal cells is also shown. Copyright © 2007 S. Karger AG. Fil:Calafat, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Larocca, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Roca, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pérez Leirós, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v14_n3-4_p175_Calafat http://hdl.handle.net/20.500.12110/paper_10217401_v14_n3-4_p175_Calafat
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Apoptotic acinar cells Exocrinopathy Macrophages Neuroimmune Nitric oxide NOD mice gamma interferon interleukin 10 lipopolysaccharide nitric oxide nitrite vasoactive intestinal polypeptide acinar cell animal cell animal model apoptosis conference paper controlled study female macrophage mouse nonhuman nonobese diabetic mouse peritoneum macrophage priority journal Sjoegren syndrome stimulation submandibular gland Animals Apoptosis Cells, Cultured Disease Models, Animal Epithelial Cells Epithelium Female Inflammation Mediators Interferon Type II Interleukin-10 Lipopolysaccharides Macrophages Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Peritoneum Sjogren's Syndrome Submandibular Gland Vasoactive Intestinal Peptide
spellingShingle	Apoptotic acinar cells Exocrinopathy Macrophages Neuroimmune Nitric oxide NOD mice gamma interferon interleukin 10 lipopolysaccharide nitric oxide nitrite vasoactive intestinal polypeptide acinar cell animal cell animal model apoptosis conference paper controlled study female macrophage mouse nonhuman nonobese diabetic mouse peritoneum macrophage priority journal Sjoegren syndrome stimulation submandibular gland Animals Apoptosis Cells, Cultured Disease Models, Animal Epithelial Cells Epithelium Female Inflammation Mediators Interferon Type II Interleukin-10 Lipopolysaccharides Macrophages Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Peritoneum Sjogren's Syndrome Submandibular Gland Vasoactive Intestinal Peptide Calafat, Mario José Larocca, Luciana Roca, Valeria Inés Pérez Leirós, Claudia NOD mice exocrinopathy: Towards a neuroimmune link
topic_facet	Apoptotic acinar cells Exocrinopathy Macrophages Neuroimmune Nitric oxide NOD mice gamma interferon interleukin 10 lipopolysaccharide nitric oxide nitrite vasoactive intestinal polypeptide acinar cell animal cell animal model apoptosis conference paper controlled study female macrophage mouse nonhuman nonobese diabetic mouse peritoneum macrophage priority journal Sjoegren syndrome stimulation submandibular gland Animals Apoptosis Cells, Cultured Disease Models, Animal Epithelial Cells Epithelium Female Inflammation Mediators Interferon Type II Interleukin-10 Lipopolysaccharides Macrophages Mice Mice, Inbred BALB C Mice, Inbred NOD Neuroimmunomodulation Nitric Oxide Peritoneum Sjogren's Syndrome Submandibular Gland Vasoactive Intestinal Peptide
description	Sjögren's syndrome (SS) is a chronic autoimmune disorder of exocrine glands characterized as an autoimmune exocrinopathy and more specifically as an autoimmune epithelitis. An impaired balance of neuroimmune interactions mediated by vasoactive intestinal peptide (VIP) in the target organ at early stages of disease is explored by means of the nonobese diabetic (NOD) mouse model of SS. We have previously described a reduced salivary secretion and signaling upon VIP stimulation. The effect reflected a differential regulation of the neural isoform of nitric oxide synthase by calcium calmodulin kinase II and occurred prior to the appearance of detectable levels of cytokines in NOD glands. VIP acting on NOD macrophages treated with lipopolysaccharide promoted anti-inflammatory effects by inhibiting nitric oxide synthase induction as well as IL-12 and TNF-α production, while stimulating IL-10. Here we present evidence on the ability of apoptotic acinar cells from submandibular glands of NOD mice to stimulate nitric oxide in both peritoneal and glandular macrophage pools to a similar extent as lipopolysaccharide + IFN-γ. VIP was not effective to prevent nitrite accumulation and modestly increased IL-10 levels in macrophages coincubated with acinar cells. An enhanced nitrite response of NOD glandular macrophages in basal and stimulated conditions compared to peritoneal cells is also shown. Copyright © 2007 S. Karger AG.
author	Calafat, Mario José Larocca, Luciana Roca, Valeria Inés Pérez Leirós, Claudia
author_facet	Calafat, Mario José Larocca, Luciana Roca, Valeria Inés Pérez Leirós, Claudia
author_sort	Calafat, Mario José
title	NOD mice exocrinopathy: Towards a neuroimmune link
title_short	NOD mice exocrinopathy: Towards a neuroimmune link
title_full	NOD mice exocrinopathy: Towards a neuroimmune link
title_fullStr	NOD mice exocrinopathy: Towards a neuroimmune link
title_full_unstemmed	NOD mice exocrinopathy: Towards a neuroimmune link
title_sort	nod mice exocrinopathy: towards a neuroimmune link
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v14_n3-4_p175_Calafat http://hdl.handle.net/20.500.12110/paper_10217401_v14_n3-4_p175_Calafat
work_keys_str_mv	AT calafatmariojose nodmiceexocrinopathytowardsaneuroimmunelink AT laroccaluciana nodmiceexocrinopathytowardsaneuroimmunelink AT rocavaleriaines nodmiceexocrinopathytowardsaneuroimmunelink AT perezleirosclaudia nodmiceexocrinopathytowardsaneuroimmunelink
_version_	1768542701470351360

NOD mice exocrinopathy: Towards a neuroimmune link

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