Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents
The interaction of novel zinc (II) cationic phthalocyanines with CT-DNA was studied using absorption and fluorescence spectroscopy, as well as thermal denaturation profiles. Results showed an electrostatic interaction between the phthalocyanines and CT-DNA. The properties of these phthalocyanines we...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p29_LopezZeballos http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p29_LopezZeballos |
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paper:paper_10111344_v136_n_p29_LopezZeballos2023-06-08T15:59:39Z Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents Dicelio, Lelia Elina Aggregation Calf thymus DNA Fluorescence Phthalocyanines 2,9(10),16(17),23(24) tetrakis [(n butyl n methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide 2,9(10),16(17),23(24) tetrakis[(2 trimethylammonium)ethyl sulfanyl]phthalocyaninatozinc(II) tetraioide 2,9(10),16(17),23(24) tetrakis[(n dibutyl n methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide cation DNA dye iodide macrocyclic compound phthalocyanine sulfur trimethylammonium salt derivative unclassified drug zinc calf thymus DNA cation DNA indole derivative phthalocyanine absorption article binding affinity chemical structure denaturation DNA binding DNA helix fluorescence spectroscopy priority journal static electricity thymus chemistry DNA denaturation heat spectrofluorometry ultraviolet spectrophotometry Cations DNA Hot Temperature Indoles Nucleic Acid Denaturation Spectrometry, Fluorescence Spectrophotometry, Ultraviolet The interaction of novel zinc (II) cationic phthalocyanines with CT-DNA was studied using absorption and fluorescence spectroscopy, as well as thermal denaturation profiles. Results showed an electrostatic interaction between the phthalocyanines and CT-DNA. The properties of these phthalocyanines were compared taking the structure of the macrocycle peripheral substituents into account. 2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammonium)ethylsulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc6) had a greater affinity for the CT-DNA helix than its bioisoster 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N- methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide (Pc7). 2,9(10),16(17),23(24)-tetrakis[(2-trimethylammonium)ethyl-sulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc13) also carried a sulfur atom like Pc6, but linked to bulky substituents such as trimethylammonium groups. The planar aromatic region of the cationic phthalocyanines in this study appears to be unable to facilitate their intercalation with CT-DNA. © 2014 Elsevier B.V. All rights reserved. Fil:Dicelio, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p29_LopezZeballos http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p29_LopezZeballos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Aggregation Calf thymus DNA Fluorescence Phthalocyanines 2,9(10),16(17),23(24) tetrakis [(n butyl n methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide 2,9(10),16(17),23(24) tetrakis[(2 trimethylammonium)ethyl sulfanyl]phthalocyaninatozinc(II) tetraioide 2,9(10),16(17),23(24) tetrakis[(n dibutyl n methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide cation DNA dye iodide macrocyclic compound phthalocyanine sulfur trimethylammonium salt derivative unclassified drug zinc calf thymus DNA cation DNA indole derivative phthalocyanine absorption article binding affinity chemical structure denaturation DNA binding DNA helix fluorescence spectroscopy priority journal static electricity thymus chemistry DNA denaturation heat spectrofluorometry ultraviolet spectrophotometry Cations DNA Hot Temperature Indoles Nucleic Acid Denaturation Spectrometry, Fluorescence Spectrophotometry, Ultraviolet |
| spellingShingle |
Aggregation Calf thymus DNA Fluorescence Phthalocyanines 2,9(10),16(17),23(24) tetrakis [(n butyl n methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide 2,9(10),16(17),23(24) tetrakis[(2 trimethylammonium)ethyl sulfanyl]phthalocyaninatozinc(II) tetraioide 2,9(10),16(17),23(24) tetrakis[(n dibutyl n methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide cation DNA dye iodide macrocyclic compound phthalocyanine sulfur trimethylammonium salt derivative unclassified drug zinc calf thymus DNA cation DNA indole derivative phthalocyanine absorption article binding affinity chemical structure denaturation DNA binding DNA helix fluorescence spectroscopy priority journal static electricity thymus chemistry DNA denaturation heat spectrofluorometry ultraviolet spectrophotometry Cations DNA Hot Temperature Indoles Nucleic Acid Denaturation Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Dicelio, Lelia Elina Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| topic_facet |
Aggregation Calf thymus DNA Fluorescence Phthalocyanines 2,9(10),16(17),23(24) tetrakis [(n butyl n methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide 2,9(10),16(17),23(24) tetrakis[(2 trimethylammonium)ethyl sulfanyl]phthalocyaninatozinc(II) tetraioide 2,9(10),16(17),23(24) tetrakis[(n dibutyl n methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide cation DNA dye iodide macrocyclic compound phthalocyanine sulfur trimethylammonium salt derivative unclassified drug zinc calf thymus DNA cation DNA indole derivative phthalocyanine absorption article binding affinity chemical structure denaturation DNA binding DNA helix fluorescence spectroscopy priority journal static electricity thymus chemistry DNA denaturation heat spectrofluorometry ultraviolet spectrophotometry Cations DNA Hot Temperature Indoles Nucleic Acid Denaturation Spectrometry, Fluorescence Spectrophotometry, Ultraviolet |
| description |
The interaction of novel zinc (II) cationic phthalocyanines with CT-DNA was studied using absorption and fluorescence spectroscopy, as well as thermal denaturation profiles. Results showed an electrostatic interaction between the phthalocyanines and CT-DNA. The properties of these phthalocyanines were compared taking the structure of the macrocycle peripheral substituents into account. 2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammonium)ethylsulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc6) had a greater affinity for the CT-DNA helix than its bioisoster 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N- methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide (Pc7). 2,9(10),16(17),23(24)-tetrakis[(2-trimethylammonium)ethyl-sulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc13) also carried a sulfur atom like Pc6, but linked to bulky substituents such as trimethylammonium groups. The planar aromatic region of the cationic phthalocyanines in this study appears to be unable to facilitate their intercalation with CT-DNA. © 2014 Elsevier B.V. All rights reserved. |
| author |
Dicelio, Lelia Elina |
| author_facet |
Dicelio, Lelia Elina |
| author_sort |
Dicelio, Lelia Elina |
| title |
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| title_short |
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| title_full |
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| title_fullStr |
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| title_full_unstemmed |
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents |
| title_sort |
interaction of cationic phthalocyanines with dna. importance of the structure of the substituents |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p29_LopezZeballos http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p29_LopezZeballos |
| work_keys_str_mv |
AT dicelioleliaelina interactionofcationicphthalocyanineswithdnaimportanceofthestructureofthesubstituents |
| _version_ |
1768546595154952192 |