An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes

The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic proper...

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Detalles Bibliográficos
Autor principal: Dicelio, Lelia Elina
Publicado: 2012
Materias:
Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10106030_v235_n_p7_LopezZeballos
http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_10106030_v235_n_p7_LopezZeballos
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spelling paper:paper_10106030_v235_n_p7_LopezZeballos2023-06-08T15:59:35Z An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes Dicelio, Lelia Elina Carriers Liposomes Phthalocyanines Singlet oxygen Stability The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic properties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol (PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80. © 2012 Elsevier B.V. Fil:Dicelio, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10106030_v235_n_p7_LopezZeballos http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
spellingShingle Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
Dicelio, Lelia Elina
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
topic_facet Carriers
Liposomes
Phthalocyanines
Singlet oxygen
Stability
description The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic properties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol (PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80. © 2012 Elsevier B.V.
author Dicelio, Lelia Elina
author_facet Dicelio, Lelia Elina
author_sort Dicelio, Lelia Elina
title An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_short An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_fullStr An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full_unstemmed An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_sort exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(ii) phthalocyanine incorporated into liposomes
publishDate 2012
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10106030_v235_n_p7_LopezZeballos
http://hdl.handle.net/20.500.12110/paper_10106030_v235_n_p7_LopezZeballos
work_keys_str_mv AT dicelioleliaelina anexhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
AT dicelioleliaelina exhaustivestudyofanovelsulfurlinkedadamantanetetrasubstitutedzinciiphthalocyanineincorporatedintoliposomes
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