Influence of mast cells on two murine mammary adenocarcinomas
A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine...
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1996
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paper:paper_10104283_v17_n6_p345_DeCidre2023-06-08T15:59:33Z Influence of mast cells on two murine mammary adenocarcinomas Eijan, Ana María Bertolesi, Gabriel Esteban Adenocarcinoma Heparin Mast cells Tumor cell growth animal cell animal experiment animal model article breast carcinoma cell interaction controlled study female lung metastasis mast cell mouse nonhuman priority journal A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it. © 1996 S. Karger AG, Basel. Fil:Eijan, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bertolesi, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10104283_v17_n6_p345_DeCidre http://hdl.handle.net/20.500.12110/paper_10104283_v17_n6_p345_DeCidre |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adenocarcinoma Heparin Mast cells Tumor cell growth animal cell animal experiment animal model article breast carcinoma cell interaction controlled study female lung metastasis mast cell mouse nonhuman priority journal |
| spellingShingle |
Adenocarcinoma Heparin Mast cells Tumor cell growth animal cell animal experiment animal model article breast carcinoma cell interaction controlled study female lung metastasis mast cell mouse nonhuman priority journal Eijan, Ana María Bertolesi, Gabriel Esteban Influence of mast cells on two murine mammary adenocarcinomas |
| topic_facet |
Adenocarcinoma Heparin Mast cells Tumor cell growth animal cell animal experiment animal model article breast carcinoma cell interaction controlled study female lung metastasis mast cell mouse nonhuman priority journal |
| description |
A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it. © 1996 S. Karger AG, Basel. |
| author |
Eijan, Ana María Bertolesi, Gabriel Esteban |
| author_facet |
Eijan, Ana María Bertolesi, Gabriel Esteban |
| author_sort |
Eijan, Ana María |
| title |
Influence of mast cells on two murine mammary adenocarcinomas |
| title_short |
Influence of mast cells on two murine mammary adenocarcinomas |
| title_full |
Influence of mast cells on two murine mammary adenocarcinomas |
| title_fullStr |
Influence of mast cells on two murine mammary adenocarcinomas |
| title_full_unstemmed |
Influence of mast cells on two murine mammary adenocarcinomas |
| title_sort |
influence of mast cells on two murine mammary adenocarcinomas |
| publishDate |
1996 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10104283_v17_n6_p345_DeCidre http://hdl.handle.net/20.500.12110/paper_10104283_v17_n6_p345_DeCidre |
| work_keys_str_mv |
AT eijananamaria influenceofmastcellsontwomurinemammaryadenocarcinomas AT bertolesigabrielesteban influenceofmastcellsontwomurinemammaryadenocarcinomas |
| _version_ |
1768542850122776576 |