New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase

As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these...

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Autores principales:	Stortz, Carlos Arturo, Szajnman, Sergio Hernán, Moreno, Silvia N. J., Rodríguez, Juan Bautista
Publicado:	2014
Materias:	Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi 1 [(n alkylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n decylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n hexylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n octylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n pentylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 2 (decylamino)acetic acid 2 (hexylamino)acetic acid 2 (n heptylamino)acetic acid 2 (n pentylamino)acetic acid 2 (octylamino)acetic acid 2 alkylaminoethyl 1 hydroxy 1,1 bisphosphonic acid derivative benznidazole bisphosphonic acid derivative geranyltransferase risedronic acid unclassified drug article binding site controlled study density functional theory drug activity drug conformation drug potency drug screening drug structure drug synthesis growth inhibition hydrogen bond Leishmania donovani molecular recognition nonhuman Plasmodium falciparum Antiparasitic Agents Diphosphonates Drug Design Geranyltranstransferase Structure-Activity Relationship Toxoplasma
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680896_v22_n1_p398_FerrerCasal http://hdl.handle.net/20.500.12110/paper_09680896_v22_n1_p398_FerrerCasal
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09680896_v22_n1_p398_FerrerCasal
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spelling	paper:paper_09680896_v22_n1_p398_FerrerCasal2023-06-08T15:58:57Z New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase Stortz, Carlos Arturo Szajnman, Sergio Hernán Moreno, Silvia N. J. Rodríguez, Juan Bautista Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi 1 [(n alkylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n decylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n hexylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n octylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n pentylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 2 (decylamino)acetic acid 2 (hexylamino)acetic acid 2 (n heptylamino)acetic acid 2 (n pentylamino)acetic acid 2 (octylamino)acetic acid 2 alkylaminoethyl 1 hydroxy 1,1 bisphosphonic acid derivative benznidazole bisphosphonic acid derivative geranyltransferase risedronic acid unclassified drug article binding site controlled study density functional theory drug activity drug conformation drug potency drug screening drug structure drug synthesis growth inhibition hydrogen bond Leishmania donovani molecular recognition nonhuman Plasmodium falciparum Toxoplasma gondii Trypanosoma cruzi Toxoplasma gondii Trypanosoma cruzi Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi Antiparasitic Agents Diphosphonates Drug Design Geranyltranstransferase Structure-Activity Relationship Toxoplasma Trypanosoma cruzi As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma gondii, respectively, and also towards their target enzymes, T. cruzi and T. gondii farnesyl pyrophosphate synthase (FPPS), respectively. Surprisingly, while most pharmacologically active bisphosphonates have a hydroxyl group at the C-1 position, the additional presence of an amino group at C-3 resulted in decreased activity towards either T. cruzi cells or TcFPPS. Density functional theory calculations justify this unexpected behavior. Although these compounds were devoid of activity against T. cruzi cells and TcFPPS, they were efficient growth inhibitors of tachyzoites of T. gondii. This activity was associated with a potent inhibition of the enzymatic activity of TgFPPS. Compound 28 arises as a main example of this family of compounds exhibiting an ED50 value of 4.7 μM against tachyzoites of T. gondii and an IC50 of 0.051 μM against TgFPPS. © 2013 Published by Elsevier Ltd. All rights reserved. Fil:Stortz, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szajnman, S.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Moreno, S.N.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680896_v22_n1_p398_FerrerCasal http://hdl.handle.net/20.500.12110/paper_09680896_v22_n1_p398_FerrerCasal
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi 1 [(n alkylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n decylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n hexylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n octylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n pentylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 2 (decylamino)acetic acid 2 (hexylamino)acetic acid 2 (n heptylamino)acetic acid 2 (n pentylamino)acetic acid 2 (octylamino)acetic acid 2 alkylaminoethyl 1 hydroxy 1,1 bisphosphonic acid derivative benznidazole bisphosphonic acid derivative geranyltransferase risedronic acid unclassified drug article binding site controlled study density functional theory drug activity drug conformation drug potency drug screening drug structure drug synthesis growth inhibition hydrogen bond Leishmania donovani molecular recognition nonhuman Plasmodium falciparum Toxoplasma gondii Trypanosoma cruzi Toxoplasma gondii Trypanosoma cruzi Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi Antiparasitic Agents Diphosphonates Drug Design Geranyltranstransferase Structure-Activity Relationship Toxoplasma Trypanosoma cruzi
spellingShingle	Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi 1 [(n alkylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n decylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n hexylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n octylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n pentylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 2 (decylamino)acetic acid 2 (hexylamino)acetic acid 2 (n heptylamino)acetic acid 2 (n pentylamino)acetic acid 2 (octylamino)acetic acid 2 alkylaminoethyl 1 hydroxy 1,1 bisphosphonic acid derivative benznidazole bisphosphonic acid derivative geranyltransferase risedronic acid unclassified drug article binding site controlled study density functional theory drug activity drug conformation drug potency drug screening drug structure drug synthesis growth inhibition hydrogen bond Leishmania donovani molecular recognition nonhuman Plasmodium falciparum Toxoplasma gondii Trypanosoma cruzi Toxoplasma gondii Trypanosoma cruzi Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi Antiparasitic Agents Diphosphonates Drug Design Geranyltranstransferase Structure-Activity Relationship Toxoplasma Trypanosoma cruzi Stortz, Carlos Arturo Szajnman, Sergio Hernán Moreno, Silvia N. J. Rodríguez, Juan Bautista New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
topic_facet	Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi 1 [(n alkylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n decylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n hexylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n octylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 1 [(n pentylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid 2 (decylamino)acetic acid 2 (hexylamino)acetic acid 2 (n heptylamino)acetic acid 2 (n pentylamino)acetic acid 2 (octylamino)acetic acid 2 alkylaminoethyl 1 hydroxy 1,1 bisphosphonic acid derivative benznidazole bisphosphonic acid derivative geranyltransferase risedronic acid unclassified drug article binding site controlled study density functional theory drug activity drug conformation drug potency drug screening drug structure drug synthesis growth inhibition hydrogen bond Leishmania donovani molecular recognition nonhuman Plasmodium falciparum Toxoplasma gondii Trypanosoma cruzi Toxoplasma gondii Trypanosoma cruzi Antiparasitic agents Bisphosphonates Farnesyl pyrophosphate synthase Toxoplasma gondii Trypanosoma cruzi Antiparasitic Agents Diphosphonates Drug Design Geranyltranstransferase Structure-Activity Relationship Toxoplasma Trypanosoma cruzi
description	As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma gondii, respectively, and also towards their target enzymes, T. cruzi and T. gondii farnesyl pyrophosphate synthase (FPPS), respectively. Surprisingly, while most pharmacologically active bisphosphonates have a hydroxyl group at the C-1 position, the additional presence of an amino group at C-3 resulted in decreased activity towards either T. cruzi cells or TcFPPS. Density functional theory calculations justify this unexpected behavior. Although these compounds were devoid of activity against T. cruzi cells and TcFPPS, they were efficient growth inhibitors of tachyzoites of T. gondii. This activity was associated with a potent inhibition of the enzymatic activity of TgFPPS. Compound 28 arises as a main example of this family of compounds exhibiting an ED50 value of 4.7 μM against tachyzoites of T. gondii and an IC50 of 0.051 μM against TgFPPS. © 2013 Published by Elsevier Ltd. All rights reserved.
author	Stortz, Carlos Arturo Szajnman, Sergio Hernán Moreno, Silvia N. J. Rodríguez, Juan Bautista
author_facet	Stortz, Carlos Arturo Szajnman, Sergio Hernán Moreno, Silvia N. J. Rodríguez, Juan Bautista
author_sort	Stortz, Carlos Arturo
title	New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
title_short	New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
title_full	New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
title_fullStr	New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
title_full_unstemmed	New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
title_sort	new insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680896_v22_n1_p398_FerrerCasal http://hdl.handle.net/20.500.12110/paper_09680896_v22_n1_p398_FerrerCasal
work_keys_str_mv	AT stortzcarlosarturo newinsightsintomolecularrecognitionof11bisphosphonicacidsbyfarnesyldiphosphatesynthase AT szajnmansergiohernan newinsightsintomolecularrecognitionof11bisphosphonicacidsbyfarnesyldiphosphatesynthase AT morenosilvianj newinsightsintomolecularrecognitionof11bisphosphonicacidsbyfarnesyldiphosphatesynthase AT rodriguezjuanbautista newinsightsintomolecularrecognitionof11bisphosphonicacidsbyfarnesyldiphosphatesynthase
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New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase

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