Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral

Recurrent herpes simplex virus (HSV) infections of the eye result in corneal damage and eventually loss of vision. Therefore, there is a continuing need to develop new antiviral drugs. Our laboratory is engaged in searching for natural compounds with antiviral activity. We previously reported that m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alche, Laura Edith, Coto, Celia Esther
Publicado:	2001
Materias:	antivirus agent meliacine plant extract unclassified drug animal experiment animal model animal tissue antiviral activity cellular immunity controlled study cornea injury disease severity drug effect drug efficacy drug mechanism herpes simplex keratitis Herpes simplex virus in vitro study melia azedarach mouse nonhuman plant review T lymphocyte treatment outcome virus adsorption virus load virus replication visual impairment
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche http://hdl.handle.net/20.500.12110/paper_09652310_v9_n8_p132_Alche
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09652310_v9_n8_p132_Alche
record_format	dspace
spelling	paper:paper_09652310_v9_n8_p132_Alche2023-06-08T15:58:39Z Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral Alche, Laura Edith Coto, Celia Esther antivirus agent meliacine plant extract unclassified drug animal experiment animal model animal tissue antiviral activity cellular immunity controlled study cornea injury disease severity drug effect drug efficacy drug mechanism herpes simplex keratitis Herpes simplex virus in vitro study melia azedarach mouse nonhuman plant review T lymphocyte treatment outcome virus adsorption virus load virus replication visual impairment Recurrent herpes simplex virus (HSV) infections of the eye result in corneal damage and eventually loss of vision. Therefore, there is a continuing need to develop new antiviral drugs. Our laboratory is engaged in searching for natural compounds with antiviral activity. We previously reported that meliacine (MA), a partially purified compound isolated from crude leaf extracts from Melia azedarach L., effectively inhibits HSV-I multiplication in vitro when added before or after infection. Our present findings indicate that MA prevents the development of murine herpetic stromal keratitis by affecting both viral yields in the eyes as well as the incidence and severity of the signs of disease, when administered topically either before or after infection, with no toxic effects [I]. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche http://hdl.handle.net/20.500.12110/paper_09652310_v9_n8_p132_Alche
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antivirus agent meliacine plant extract unclassified drug animal experiment animal model animal tissue antiviral activity cellular immunity controlled study cornea injury disease severity drug effect drug efficacy drug mechanism herpes simplex keratitis Herpes simplex virus in vitro study melia azedarach mouse nonhuman plant review T lymphocyte treatment outcome virus adsorption virus load virus replication visual impairment
spellingShingle	antivirus agent meliacine plant extract unclassified drug animal experiment animal model animal tissue antiviral activity cellular immunity controlled study cornea injury disease severity drug effect drug efficacy drug mechanism herpes simplex keratitis Herpes simplex virus in vitro study melia azedarach mouse nonhuman plant review T lymphocyte treatment outcome virus adsorption virus load virus replication visual impairment Alche, Laura Edith Coto, Celia Esther Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
topic_facet	antivirus agent meliacine plant extract unclassified drug animal experiment animal model animal tissue antiviral activity cellular immunity controlled study cornea injury disease severity drug effect drug efficacy drug mechanism herpes simplex keratitis Herpes simplex virus in vitro study melia azedarach mouse nonhuman plant review T lymphocyte treatment outcome virus adsorption virus load virus replication visual impairment
description	Recurrent herpes simplex virus (HSV) infections of the eye result in corneal damage and eventually loss of vision. Therefore, there is a continuing need to develop new antiviral drugs. Our laboratory is engaged in searching for natural compounds with antiviral activity. We previously reported that meliacine (MA), a partially purified compound isolated from crude leaf extracts from Melia azedarach L., effectively inhibits HSV-I multiplication in vitro when added before or after infection. Our present findings indicate that MA prevents the development of murine herpetic stromal keratitis by affecting both viral yields in the eyes as well as the incidence and severity of the signs of disease, when administered topically either before or after infection, with no toxic effects [I].
author	Alche, Laura Edith Coto, Celia Esther
author_facet	Alche, Laura Edith Coto, Celia Esther
author_sort	Alche, Laura Edith
title	Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
title_short	Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
title_full	Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
title_fullStr	Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
title_full_unstemmed	Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
title_sort	effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral
publishDate	2001
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche http://hdl.handle.net/20.500.12110/paper_09652310_v9_n8_p132_Alche
work_keys_str_mv	AT alchelauraedith effectivetreatmentofmouseherpeticstromalkeratitiswithmeliacineaplantderivedantiviral AT cotoceliaesther effectivetreatmentofmouseherpeticstromalkeratitiswithmeliacineaplantderivedantiviral
_version_	1768546453795373056

Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral

Ejemplares similares