Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleo...
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paper:paper_0960894X_v14_n7_p1703_Gompel2023-06-08T15:57:49Z Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum Puricelli, Lydia Inés Palermo, Jorge Alejandro Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. © 2004 Elsevier Ltd. All rights reserved. Fil:Puricelli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Palermo, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v14_n7_p1703_Gompel http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes |
spellingShingle |
Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes Puricelli, Lydia Inés Palermo, Jorge Alejandro Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
topic_facet |
Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes |
description |
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. © 2004 Elsevier Ltd. All rights reserved. |
author |
Puricelli, Lydia Inés Palermo, Jorge Alejandro |
author_facet |
Puricelli, Lydia Inés Palermo, Jorge Alejandro |
author_sort |
Puricelli, Lydia Inés |
title |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_short |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_full |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_fullStr |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_full_unstemmed |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_sort |
meridianins, a new family of protein kinase inhibitors isolated from the ascidian aplidium meridianum |
publishDate |
2004 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v14_n7_p1703_Gompel http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel |
work_keys_str_mv |
AT puricellilydiaines meridianinsanewfamilyofproteinkinaseinhibitorsisolatedfromtheascidianaplidiummeridianum AT palermojorgealejandro meridianinsanewfamilyofproteinkinaseinhibitorsisolatedfromtheascidianaplidiummeridianum |
_version_ |
1768543191235035136 |