Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone

3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induc...

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Detalles Bibliográficos
Publicado:	2003
Materias:	3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n3_p343_Veleiro http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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