Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone

3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induc...

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Publicado:	2003
Materias:	3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n3_p343_Veleiro http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0960894X_v13_n3_p343_Veleiro
record_format	dspace
spelling	paper:paper_0960894X_v13_n3_p343_Veleiro2023-06-08T15:57:49Z Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone 3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae 3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid. © 2002 Elsevier Science Ltd. All rights reserved. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n3_p343_Veleiro http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae
spellingShingle	3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
topic_facet	3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae
description	3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid. © 2002 Elsevier Science Ltd. All rights reserved.
title	Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
title_short	Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
title_full	Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
title_fullStr	Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
title_full_unstemmed	Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
title_sort	synthesis and gabaa receptor activity of a 6,19-oxido analogue of pregnanolone
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n3_p343_Veleiro http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro
_version_	1768543907078995968

Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone

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