Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular for...
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2003
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n19_p3231_Szajnman http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
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paper:paper_0960894X_v13_n19_p3231_Szajnman2023-06-08T15:57:49Z Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase Szajnman, Sergio Hernán Rodríguez, Juan Bautista fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. © 2003 Elsevier Ltd. All rights reserved. Fil:Szajnman, S.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n19_p3231_Szajnman http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi |
| spellingShingle |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi Szajnman, Sergio Hernán Rodríguez, Juan Bautista Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| topic_facet |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi |
| description |
Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. © 2003 Elsevier Ltd. All rights reserved. |
| author |
Szajnman, Sergio Hernán Rodríguez, Juan Bautista |
| author_facet |
Szajnman, Sergio Hernán Rodríguez, Juan Bautista |
| author_sort |
Szajnman, Sergio Hernán |
| title |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_short |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_full |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_fullStr |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_full_unstemmed |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_sort |
bisphosphonates derived from fatty acids are potent inhibitors of trypanosoma cruzi farnesyl pyrophosphate synthase |
| publishDate |
2003 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n19_p3231_Szajnman http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
| work_keys_str_mv |
AT szajnmansergiohernan bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase AT rodriguezjuanbautista bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase |
| _version_ |
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