In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate

Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-response relationships for these last two effects of ET-1 were found to be biphasic with a maximum (corresponding to...

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Autores principales:	Pecci, Adali, Cozza, Eduardo Néstor
Publicado:	1993
Materias:	aldosterone angiotensin angiotensin i enalapril endothelin 1 aldosterone blood level aldosterone release animal experiment article intravenous drug administration male nonhuman priority journal rat steroidogenesis Aldosterone Angiotensin II Animal Cytosol Dose-Response Relationship, Drug Enalapril Endothelins Male Mitochondria Rats Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v45_n6_p555_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v45_n6_p555_Pecci
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09600760_v45_n6_p555_Pecci
record_format	dspace
spelling	paper:paper_09600760_v45_n6_p555_Pecci2023-06-08T15:57:23Z In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate Pecci, Adali Cozza, Eduardo Néstor aldosterone angiotensin angiotensin i enalapril endothelin 1 aldosterone blood level aldosterone release animal experiment article intravenous drug administration male nonhuman priority journal rat steroidogenesis Aldosterone Angiotensin II Animal Cytosol Dose-Response Relationship, Drug Enalapril Endothelins Male Mitochondria Rats Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-response relationships for these last two effects of ET-1 were found to be biphasic with a maximum (corresponding to 80 to 200% increase) at 50 to 80 ng ET-1/kg/min, and were also dependent on the infusion rate. Plasma aldosterone levels were also increased in a similar ratio. Previous infusion of the converting enzyme inhibitor enalapril did not affect the ET-1-induced increase in steroidogenesis. Finally, pregnenolene production was also increased in incubations of mitochondria from treated rats. These results indicate that ET-1 augments aldosteronogenesis by increasing the early as well as the late pathway. These effects were independent of the formation of angiottensin II. Isolated glomerulosa cells responded to ET-1 increasing aldosterone production in a dose-related fashion. These results confirm a direct effect of ET-1 on the adrenal gland in vivo. © 1993. Fil:Pecci, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v45_n6_p555_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v45_n6_p555_Pecci
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	aldosterone angiotensin angiotensin i enalapril endothelin 1 aldosterone blood level aldosterone release animal experiment article intravenous drug administration male nonhuman priority journal rat steroidogenesis Aldosterone Angiotensin II Animal Cytosol Dose-Response Relationship, Drug Enalapril Endothelins Male Mitochondria Rats Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia
spellingShingle	aldosterone angiotensin angiotensin i enalapril endothelin 1 aldosterone blood level aldosterone release animal experiment article intravenous drug administration male nonhuman priority journal rat steroidogenesis Aldosterone Angiotensin II Animal Cytosol Dose-Response Relationship, Drug Enalapril Endothelins Male Mitochondria Rats Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Pecci, Adali Cozza, Eduardo Néstor In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
topic_facet	aldosterone angiotensin angiotensin i enalapril endothelin 1 aldosterone blood level aldosterone release animal experiment article intravenous drug administration male nonhuman priority journal rat steroidogenesis Aldosterone Angiotensin II Animal Cytosol Dose-Response Relationship, Drug Enalapril Endothelins Male Mitochondria Rats Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia
description	Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-response relationships for these last two effects of ET-1 were found to be biphasic with a maximum (corresponding to 80 to 200% increase) at 50 to 80 ng ET-1/kg/min, and were also dependent on the infusion rate. Plasma aldosterone levels were also increased in a similar ratio. Previous infusion of the converting enzyme inhibitor enalapril did not affect the ET-1-induced increase in steroidogenesis. Finally, pregnenolene production was also increased in incubations of mitochondria from treated rats. These results indicate that ET-1 augments aldosteronogenesis by increasing the early as well as the late pathway. These effects were independent of the formation of angiottensin II. Isolated glomerulosa cells responded to ET-1 increasing aldosterone production in a dose-related fashion. These results confirm a direct effect of ET-1 on the adrenal gland in vivo. © 1993.
author	Pecci, Adali Cozza, Eduardo Néstor
author_facet	Pecci, Adali Cozza, Eduardo Néstor
author_sort	Pecci, Adali
title	In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
title_short	In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
title_full	In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
title_fullStr	In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
title_full_unstemmed	In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
title_sort	in vivo stimulation of aldosterone biosynthesis by endothelin: loci of action and effects of doses and infusion rate
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v45_n6_p555_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v45_n6_p555_Pecci
work_keys_str_mv	AT pecciadali invivostimulationofaldosteronebiosynthesisbyendothelinlociofactionandeffectsofdosesandinfusionrate AT cozzaeduardonestor invivostimulationofaldosteronebiosynthesisbyendothelinlociofactionandeffectsofdosesandinfusionrate
_version_	1768541713437032448

In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate

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