Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome

The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structu...

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Autores principales:	Abramovich, Dalhia Nurit, Irusta, Griselda, Tesone, Marta, Parborell, M.Fernanda A.
Publicado:	2014
Materias:	Angiogenesis Apoptosis Cell proliferation OHSS Ovary VEGF aflibercept angiogenesis inhibitor claudin 5 Cldn5 protein, rat estradiol Flt1 protein, rat hybrid protein occludin Ocln protein, rat progesterone vascular endothelial growth factor A, rat vasculotropin A vasculotropin receptor vasculotropin receptor 1 vasculotropin receptor 2 unclassified drug vascular endothelial growth factor receptor 1 fc chimera vasculotropin vasculotropin inhibitor animal antagonists and inhibitors apoptosis blood cell proliferation drug effects endothelium cell female metabolism ovary ovary hyperstimulation pathology Sprague Dawley rat animal experiment animal model animal tissue Article controlled study corpus luteum estradiol blood level nonhuman progesterone blood level protein expression protein phosphorylation rat steroidogenesis Angiogenesis Inhibitors Animals Cell Proliferation Claudin-5 Endothelial Cells Estradiol Female Occludin Ovarian Hyperstimulation Syndrome Progesterone Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v144_nPARTB_p392_Scotti http://hdl.handle.net/20.500.12110/paper_09600760_v144_nPARTB_p392_Scotti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_09600760_v144_nPARTB_p392_Scotti2023-06-08T15:57:20Z Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome Abramovich, Dalhia Nurit Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Angiogenesis Apoptosis Cell proliferation OHSS Ovary VEGF aflibercept angiogenesis inhibitor claudin 5 Cldn5 protein, rat estradiol Flt1 protein, rat hybrid protein occludin Ocln protein, rat progesterone vascular endothelial growth factor A, rat vasculotropin A vasculotropin receptor vasculotropin receptor 1 vasculotropin receptor 2 claudin 5 estradiol occludin progesterone unclassified drug vascular endothelial growth factor receptor 1 fc chimera vasculotropin vasculotropin inhibitor vasculotropin receptor 1 vasculotropin receptor 2 animal antagonists and inhibitors apoptosis blood cell proliferation drug effects endothelium cell female metabolism ovary ovary hyperstimulation pathology Sprague Dawley rat animal experiment animal model animal tissue Article controlled study corpus luteum estradiol blood level nonhuman ovary hyperstimulation progesterone blood level protein expression protein phosphorylation rat steroidogenesis Angiogenesis Inhibitors Animals Apoptosis Cell Proliferation Claudin-5 Endothelial Cells Estradiol Female Occludin Ovarian Hyperstimulation Syndrome Ovary Progesterone Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2 The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats. © 2014 Elsevier Ltd. Fil:Abramovich, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Irusta, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Parborell, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v144_nPARTB_p392_Scotti http://hdl.handle.net/20.500.12110/paper_09600760_v144_nPARTB_p392_Scotti
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiogenesis Apoptosis Cell proliferation OHSS Ovary VEGF aflibercept angiogenesis inhibitor claudin 5 Cldn5 protein, rat estradiol Flt1 protein, rat hybrid protein occludin Ocln protein, rat progesterone vascular endothelial growth factor A, rat vasculotropin A vasculotropin receptor vasculotropin receptor 1 vasculotropin receptor 2 claudin 5 estradiol occludin progesterone unclassified drug vascular endothelial growth factor receptor 1 fc chimera vasculotropin vasculotropin inhibitor vasculotropin receptor 1 vasculotropin receptor 2 animal antagonists and inhibitors apoptosis blood cell proliferation drug effects endothelium cell female metabolism ovary ovary hyperstimulation pathology Sprague Dawley rat animal experiment animal model animal tissue Article controlled study corpus luteum estradiol blood level nonhuman ovary hyperstimulation progesterone blood level protein expression protein phosphorylation rat steroidogenesis Angiogenesis Inhibitors Animals Apoptosis Cell Proliferation Claudin-5 Endothelial Cells Estradiol Female Occludin Ovarian Hyperstimulation Syndrome Ovary Progesterone Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2
spellingShingle	Angiogenesis Apoptosis Cell proliferation OHSS Ovary VEGF aflibercept angiogenesis inhibitor claudin 5 Cldn5 protein, rat estradiol Flt1 protein, rat hybrid protein occludin Ocln protein, rat progesterone vascular endothelial growth factor A, rat vasculotropin A vasculotropin receptor vasculotropin receptor 1 vasculotropin receptor 2 claudin 5 estradiol occludin progesterone unclassified drug vascular endothelial growth factor receptor 1 fc chimera vasculotropin vasculotropin inhibitor vasculotropin receptor 1 vasculotropin receptor 2 animal antagonists and inhibitors apoptosis blood cell proliferation drug effects endothelium cell female metabolism ovary ovary hyperstimulation pathology Sprague Dawley rat animal experiment animal model animal tissue Article controlled study corpus luteum estradiol blood level nonhuman ovary hyperstimulation progesterone blood level protein expression protein phosphorylation rat steroidogenesis Angiogenesis Inhibitors Animals Apoptosis Cell Proliferation Claudin-5 Endothelial Cells Estradiol Female Occludin Ovarian Hyperstimulation Syndrome Ovary Progesterone Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2 Abramovich, Dalhia Nurit Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
topic_facet	Angiogenesis Apoptosis Cell proliferation OHSS Ovary VEGF aflibercept angiogenesis inhibitor claudin 5 Cldn5 protein, rat estradiol Flt1 protein, rat hybrid protein occludin Ocln protein, rat progesterone vascular endothelial growth factor A, rat vasculotropin A vasculotropin receptor vasculotropin receptor 1 vasculotropin receptor 2 claudin 5 estradiol occludin progesterone unclassified drug vascular endothelial growth factor receptor 1 fc chimera vasculotropin vasculotropin inhibitor vasculotropin receptor 1 vasculotropin receptor 2 animal antagonists and inhibitors apoptosis blood cell proliferation drug effects endothelium cell female metabolism ovary ovary hyperstimulation pathology Sprague Dawley rat animal experiment animal model animal tissue Article controlled study corpus luteum estradiol blood level nonhuman ovary hyperstimulation progesterone blood level protein expression protein phosphorylation rat steroidogenesis Angiogenesis Inhibitors Animals Apoptosis Cell Proliferation Claudin-5 Endothelial Cells Estradiol Female Occludin Ovarian Hyperstimulation Syndrome Ovary Progesterone Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2
description	The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats. © 2014 Elsevier Ltd.
author	Abramovich, Dalhia Nurit Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A.
author_facet	Abramovich, Dalhia Nurit Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A.
author_sort	Abramovich, Dalhia Nurit
title	Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
title_short	Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
title_full	Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
title_fullStr	Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
title_full_unstemmed	Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
title_sort	local vegf inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v144_nPARTB_p392_Scotti http://hdl.handle.net/20.500.12110/paper_09600760_v144_nPARTB_p392_Scotti
work_keys_str_mv	AT abramovichdalhianurit localvegfinhibitionpreventsovarianalterationsassociatedwithovarianhyperstimulationsyndrome AT irustagriselda localvegfinhibitionpreventsovarianalterationsassociatedwithovarianhyperstimulationsyndrome AT tesonemarta localvegfinhibitionpreventsovarianalterationsassociatedwithovarianhyperstimulationsyndrome AT parborellmfernandaa localvegfinhibitionpreventsovarianalterationsassociatedwithovarianhyperstimulationsyndrome
_version_	1768545338905329664

Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome

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