Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives

Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatory properties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mic...

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Detalles Bibliográficos
Autores principales:	Michelini, Flavia Mariana, Ramirez, Javier Alberto, Alche, Laura Edith
Publicado:	2008
Materias:	Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v111_n1-2_p111_Michelini http://hdl.handle.net/20.500.12110/paper_09600760_v111_n1-2_p111_Michelini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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