Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives

Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatory properties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mic...

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Autores principales:	Michelini, Flavia Mariana, Ramirez, Javier Alberto, Alche, Laura Edith
Publicado:	2008
Materias:	Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v111_n1-2_p111_Michelini http://hdl.handle.net/20.500.12110/paper_09600760_v111_n1-2_p111_Michelini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09600760_v111_n1-2_p111_Michelini
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spelling	paper:paper_09600760_v111_n1-2_p111_Michelini2023-06-08T15:57:19Z Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives Michelini, Flavia Mariana Ramirez, Javier Alberto Alche, Laura Edith Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatory properties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mice. (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (1) and (22S,23S)-22,23-dihydroxystigmasta-1,4-dien-3-one (2) exhibited anti-HSV-1 activity in vitro and ameliorated the signs of murine herpetic stromal keratitis (HSK), although none of the compounds showed antiviral activity in vivo. We discuss that the improvement of HSK could be due to an immunomodulatory effect of both compounds. © 2008 Elsevier Ltd. All rights reserved. Fil:Michelini, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramírez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v111_n1-2_p111_Michelini http://hdl.handle.net/20.500.12110/paper_09600760_v111_n1-2_p111_Michelini
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus
spellingShingle	Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus Michelini, Flavia Mariana Ramirez, Javier Alberto Alche, Laura Edith Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
topic_facet	Anti-inflammatory Antiviral HSV-1 Murine herpetic stromal keratitis Stigmastane analogs 22,23 dihydroxystigmast 4 en 3 one 22,23 dihydroxystigmasta 1,4 dien 3 one antiinflammatory agent antivirus agent unclassified drug animal cell animal experiment animal model article controlled study drug activity drug cytotoxicity drug inhibition drug structure drug synthesis human human cell Human immunodeficiency virus 1 in vitro study keratitis male mouse nonhuman Animals Anti-Inflammatory Agents Antiviral Agents beta-Galactosidase Cell Line Cell Survival Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells Epithelium, Corneal Formazans Herpesvirus 1, Human Humans Inhibitory Concentration 50 Keratitis, Herpetic Male Mice Mice, Inbred BALB C Molecular Structure Spectrophotometry Stigmasterol Tetrazolium Salts Time Factors Vero Cells Human herpesvirus 1 Murinae Mus
description	Stromal keratitis resulting from ocular infection with Herpes simplex virus type 1 (HSV-1) is a common cause of blindness. This report investigates the antiviral and anti-inflammatory properties of two new synthetic stigmastane analogs in the experimental model of HSV-1-induced ocular disease in mice. (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (1) and (22S,23S)-22,23-dihydroxystigmasta-1,4-dien-3-one (2) exhibited anti-HSV-1 activity in vitro and ameliorated the signs of murine herpetic stromal keratitis (HSK), although none of the compounds showed antiviral activity in vivo. We discuss that the improvement of HSK could be due to an immunomodulatory effect of both compounds. © 2008 Elsevier Ltd. All rights reserved.
author	Michelini, Flavia Mariana Ramirez, Javier Alberto Alche, Laura Edith
author_facet	Michelini, Flavia Mariana Ramirez, Javier Alberto Alche, Laura Edith
author_sort	Michelini, Flavia Mariana
title	Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
title_short	Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
title_full	Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
title_fullStr	Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
title_full_unstemmed	Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
title_sort	anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives
publishDate	2008
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v111_n1-2_p111_Michelini http://hdl.handle.net/20.500.12110/paper_09600760_v111_n1-2_p111_Michelini
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_version_	1768543191048388608

Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives

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