Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol

Oxidants play a role in several stages of carcinogenesis. A high antioxidant capacity is expected to protect 'initiated' cells from excessive oxidant toxicity. The aim of this study was to determine the chemopreventive effect of α-tocopherol (α-T) on the hepatocarcinogenesis induced with p...

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Autores principales:	Gerez, Esther Noemí, Vázquez, Elba Susana, Batlle, Alcira María del Carmen
Publicado:	1998
Materias:	α-Tocopherol Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Oxidative stress p-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase alpha tocopherol antioxidant cytochrome p450 glutathione transferase heme animal experiment animal model animal tissue antioxidant activity article controlled study liver cancer liver carcinogenesis liver metabolism male mouse nonhuman oxidative stress priority journal vitamin metabolism xenobiotic metabolism 5-Aminolevulinate Synthetase Animals Antioxidants Carcinogens Enzyme Induction Glutathione Transferase Liver Neoplasms, Experimental Male Mice Oxidative Stress p-Dimethylaminoazobenzene Vitamin E
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez http://hdl.handle.net/20.500.12110/paper_09598278_v7_n1_p69_Gerez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09598278_v7_n1_p69_Gerez
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spelling	paper:paper_09598278_v7_n1_p69_Gerez2023-06-08T15:57:12Z Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen α-Tocopherol Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Oxidative stress p-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase alpha tocopherol antioxidant cytochrome p450 glutathione transferase heme animal experiment animal model animal tissue antioxidant activity article controlled study liver cancer liver carcinogenesis liver metabolism male mouse nonhuman oxidative stress priority journal vitamin metabolism xenobiotic metabolism 5-Aminolevulinate Synthetase Animals Antioxidants Carcinogens Enzyme Induction Glutathione Transferase Liver Neoplasms, Experimental Male Mice Oxidative Stress p-Dimethylaminoazobenzene Vitamin E Oxidants play a role in several stages of carcinogenesis. A high antioxidant capacity is expected to protect 'initiated' cells from excessive oxidant toxicity. The aim of this study was to determine the chemopreventive effect of α-tocopherol (α-T) on the hepatocarcinogenesis induced with p- dimethylaminoazobenzene (DAB) in mice. The dietary administration of α-T completely reversed the induction of δ-aminolevulinate synthetase and glutathione-S-transferase (the tumoral marker enzyme). α-T greatly enhanced P 450 levels, which were even higher in animals exposed to DAB. Indirect evidence for the involvement of oxygen radicals in the DAB model of hepatocarcinogenesis was provided by increased levels of thiobarbituric acid reactive species, which were detected in animals with severe liver damage and were assessed by histological analysis. α-T reduced the degree of hepatic injury, although this vitamin produced only slight changes in the oxidative parameters evaluated. The use of α-T as a potential chemopreventive agent, particularly during the initiation stage of carcinogenesis provoked by DAB, is worthy of further study. Fil:Gerez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez http://hdl.handle.net/20.500.12110/paper_09598278_v7_n1_p69_Gerez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	α-Tocopherol Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Oxidative stress p-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase alpha tocopherol antioxidant cytochrome p450 glutathione transferase heme animal experiment animal model animal tissue antioxidant activity article controlled study liver cancer liver carcinogenesis liver metabolism male mouse nonhuman oxidative stress priority journal vitamin metabolism xenobiotic metabolism 5-Aminolevulinate Synthetase Animals Antioxidants Carcinogens Enzyme Induction Glutathione Transferase Liver Neoplasms, Experimental Male Mice Oxidative Stress p-Dimethylaminoazobenzene Vitamin E
spellingShingle	α-Tocopherol Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Oxidative stress p-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase alpha tocopherol antioxidant cytochrome p450 glutathione transferase heme animal experiment animal model animal tissue antioxidant activity article controlled study liver cancer liver carcinogenesis liver metabolism male mouse nonhuman oxidative stress priority journal vitamin metabolism xenobiotic metabolism 5-Aminolevulinate Synthetase Animals Antioxidants Carcinogens Enzyme Induction Glutathione Transferase Liver Neoplasms, Experimental Male Mice Oxidative Stress p-Dimethylaminoazobenzene Vitamin E Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
topic_facet	α-Tocopherol Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Oxidative stress p-dimethylaminoazobenzene 4 dimethylaminoazobenzene 5 aminolevulinate synthase alpha tocopherol antioxidant cytochrome p450 glutathione transferase heme animal experiment animal model animal tissue antioxidant activity article controlled study liver cancer liver carcinogenesis liver metabolism male mouse nonhuman oxidative stress priority journal vitamin metabolism xenobiotic metabolism 5-Aminolevulinate Synthetase Animals Antioxidants Carcinogens Enzyme Induction Glutathione Transferase Liver Neoplasms, Experimental Male Mice Oxidative Stress p-Dimethylaminoazobenzene Vitamin E
description	Oxidants play a role in several stages of carcinogenesis. A high antioxidant capacity is expected to protect 'initiated' cells from excessive oxidant toxicity. The aim of this study was to determine the chemopreventive effect of α-tocopherol (α-T) on the hepatocarcinogenesis induced with p- dimethylaminoazobenzene (DAB) in mice. The dietary administration of α-T completely reversed the induction of δ-aminolevulinate synthetase and glutathione-S-transferase (the tumoral marker enzyme). α-T greatly enhanced P 450 levels, which were even higher in animals exposed to DAB. Indirect evidence for the involvement of oxygen radicals in the DAB model of hepatocarcinogenesis was provided by increased levels of thiobarbituric acid reactive species, which were detected in animals with severe liver damage and were assessed by histological analysis. α-T reduced the degree of hepatic injury, although this vitamin produced only slight changes in the oxidative parameters evaluated. The use of α-T as a potential chemopreventive agent, particularly during the initiation stage of carcinogenesis provoked by DAB, is worthy of further study.
author	Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen
author_facet	Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen
author_sort	Gerez, Esther Noemí
title	Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
title_short	Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
title_full	Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
title_fullStr	Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
title_full_unstemmed	Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
title_sort	hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: protective role of α-tocopherol
publishDate	1998
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez http://hdl.handle.net/20.500.12110/paper_09598278_v7_n1_p69_Gerez
work_keys_str_mv	AT gerezesthernoemi hepaticenzymaticmetabolismalterationsandoxidativestressduringtheonsetofcarcinogenesisprotectiveroleofatocopherol AT vazquezelbasusana hepaticenzymaticmetabolismalterationsandoxidativestressduringtheonsetofcarcinogenesisprotectiveroleofatocopherol AT batllealciramariadelcarmen hepaticenzymaticmetabolismalterationsandoxidativestressduringtheonsetofcarcinogenesisprotectiveroleofatocopherol
_version_	1768542186012409856

Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol

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