Galactofuranose-containing glycoconjugates in trypanosomatids

Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-man...

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Detalles Bibliográficos
Autor principal: Muchnik de Lederkremer, Rosa María
Publicado: 1995
Materias:
Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v5_n6_p547_DeLederkremer
http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_09596658_v5_n6_p547_DeLederkremer
record_format dspace
spelling paper:paper_09596658_v5_n6_p547_DeLederkremer2023-06-08T15:57:07Z Galactofuranose-containing glycoconjugates in trypanosomatids Muchnik de Lederkremer, Rosa María Gangliosides HPTLC-immunostaining Platelets Selectin ligands Slex glycoconjugate glycoprotein lipopeptide carbohydrate analysis chemical structure leishmania priority journal review trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Carbohydrate Sequence Galactose Glycoconjugates Glycoproteins Immune Sera Molecular Sequence Data Polysaccharides Support, Non-U.S. Gov't Trypanosomatina Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-mannose chains of trypanosomatid glycoproteins. Galactofuranose is usually present linked β1→3 to Man, either as a terminal non-reducing unit, like in LPPG, or in the middle of the oligosaccharide core, as in LPG. The presence in protozoan parasites of galactose in the furanose configuration is a feature which deserves further attention since the mammalian hosts donot appear to produce glycoconjugates containing this structural unit. For that reason, hosts produceantibodies against galactofuranose, which may turn out to be important in understanding the pathogenesis and in the development of diagnostic methods. The metabolic pathways involved in the attachment to or removal of galactofuranose from glycoconjugates have not yet been elucidated. This is an area ofincipient research, but of growing importance, since it will foster the design of inhibitors which may prove to be useful for the treatment of disease. © 1995 Oxford University Press. Fil:De Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v5_n6_p547_DeLederkremer http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
spellingShingle Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
Muchnik de Lederkremer, Rosa María
Galactofuranose-containing glycoconjugates in trypanosomatids
topic_facet Gangliosides
HPTLC-immunostaining
Platelets
Selectin ligands
Slex
glycoconjugate
glycoprotein
lipopeptide
carbohydrate analysis
chemical structure
leishmania
priority journal
review
trypanosoma cruzi
Animal
Antibodies, Protozoan
Antigens, Protozoan
Carbohydrate Sequence
Galactose
Glycoconjugates
Glycoproteins
Immune Sera
Molecular Sequence Data
Polysaccharides
Support, Non-U.S. Gov't
Trypanosomatina
description Galactofuranose has been characterized in glycoinositolphospholipid (GIPL) anchor-like structures having a glycerolipid or a ceramide, as in lipopeptidophosphoglycan (LPPG) of Trypanosoma cruzi, in the oligosaccharide core of lipophosphoglycan (LPG) of Leishmania species, and also modifying high-mannose chains of trypanosomatid glycoproteins. Galactofuranose is usually present linked β1→3 to Man, either as a terminal non-reducing unit, like in LPPG, or in the middle of the oligosaccharide core, as in LPG. The presence in protozoan parasites of galactose in the furanose configuration is a feature which deserves further attention since the mammalian hosts donot appear to produce glycoconjugates containing this structural unit. For that reason, hosts produceantibodies against galactofuranose, which may turn out to be important in understanding the pathogenesis and in the development of diagnostic methods. The metabolic pathways involved in the attachment to or removal of galactofuranose from glycoconjugates have not yet been elucidated. This is an area ofincipient research, but of growing importance, since it will foster the design of inhibitors which may prove to be useful for the treatment of disease. © 1995 Oxford University Press.
author Muchnik de Lederkremer, Rosa María
author_facet Muchnik de Lederkremer, Rosa María
author_sort Muchnik de Lederkremer, Rosa María
title Galactofuranose-containing glycoconjugates in trypanosomatids
title_short Galactofuranose-containing glycoconjugates in trypanosomatids
title_full Galactofuranose-containing glycoconjugates in trypanosomatids
title_fullStr Galactofuranose-containing glycoconjugates in trypanosomatids
title_full_unstemmed Galactofuranose-containing glycoconjugates in trypanosomatids
title_sort galactofuranose-containing glycoconjugates in trypanosomatids
publishDate 1995
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v5_n6_p547_DeLederkremer
http://hdl.handle.net/20.500.12110/paper_09596658_v5_n6_p547_DeLederkremer
work_keys_str_mv AT muchnikdelederkremerrosamaria galactofuranosecontainingglycoconjugatesintrypanosomatids
_version_ 1768544922267287552

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