Characterization of dopamine receptor binding sites in the subthalamic nucleus

Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abunda...

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Publicado:	1994
Materias:	Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v5_n14_p1836_Johnson http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09594965_v5_n14_p1836_Johnson
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spelling	paper:paper_09594965_v5_n14_p1836_Johnson2023-06-08T15:56:59Z Characterization of dopamine receptor binding sites in the subthalamic nucleus Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v5_n14_p1836_Johnson http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei
spellingShingle	Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei Characterization of dopamine receptor binding sites in the subthalamic nucleus
topic_facet	Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei
description	Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd.
title	Characterization of dopamine receptor binding sites in the subthalamic nucleus
title_short	Characterization of dopamine receptor binding sites in the subthalamic nucleus
title_full	Characterization of dopamine receptor binding sites in the subthalamic nucleus
title_fullStr	Characterization of dopamine receptor binding sites in the subthalamic nucleus
title_full_unstemmed	Characterization of dopamine receptor binding sites in the subthalamic nucleus
title_sort	characterization of dopamine receptor binding sites in the subthalamic nucleus
publishDate	1994
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v5_n14_p1836_Johnson http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson
_version_	1768543333604392960

Characterization of dopamine receptor binding sites in the subthalamic nucleus

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