Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functi...
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2015
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paper:paper_0959440X_v32_n_p91_Chemes2023-06-08T15:56:57Z Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions Chemes, Lucía Beatriz de Prat Gay, Gonzalo retinoblastoma binding protein retinoblastoma protein protein adaptive evolution binding affinity coevolution convergent evolution evolutionary rate genetic conservation habitat selection Helicobacter host pathogen interaction host resistance human Human adenovirus 5 Human papillomavirus type 16 Leptospira linear motif mimicry Metapneumovirus molecular evolution molecular mimicry motif switch negative purifying selection nonhuman phylogeny physical chemistry positive selection priority journal protein assembly protein conformation protein expression protein function protein linear motif protein motif protein protein interaction protein secondary structure protein structure, function and variability purifying selection Pyrenophora regular expression regulatory evolution Review sequence alignment sequence analysis Simian virus 40 animal chemical structure chemistry genetics metabolism protein motif protein protein interaction Eukaryota Prokaryota Amino Acid Motifs Animals Evolution, Molecular Host-Pathogen Interactions Humans Models, Molecular Molecular Mimicry Protein Conformation Protein Interaction Maps Proteins Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment. © 2015 Elsevier Ltd. Fil:Chemes, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de Prat-Gay, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v32_n_p91_Chemes http://hdl.handle.net/20.500.12110/paper_0959440X_v32_n_p91_Chemes |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
retinoblastoma binding protein retinoblastoma protein protein adaptive evolution binding affinity coevolution convergent evolution evolutionary rate genetic conservation habitat selection Helicobacter host pathogen interaction host resistance human Human adenovirus 5 Human papillomavirus type 16 Leptospira linear motif mimicry Metapneumovirus molecular evolution molecular mimicry motif switch negative purifying selection nonhuman phylogeny physical chemistry positive selection priority journal protein assembly protein conformation protein expression protein function protein linear motif protein motif protein protein interaction protein secondary structure protein structure, function and variability purifying selection Pyrenophora regular expression regulatory evolution Review sequence alignment sequence analysis Simian virus 40 animal chemical structure chemistry genetics metabolism protein motif protein protein interaction Eukaryota Prokaryota Amino Acid Motifs Animals Evolution, Molecular Host-Pathogen Interactions Humans Models, Molecular Molecular Mimicry Protein Conformation Protein Interaction Maps Proteins |
| spellingShingle |
retinoblastoma binding protein retinoblastoma protein protein adaptive evolution binding affinity coevolution convergent evolution evolutionary rate genetic conservation habitat selection Helicobacter host pathogen interaction host resistance human Human adenovirus 5 Human papillomavirus type 16 Leptospira linear motif mimicry Metapneumovirus molecular evolution molecular mimicry motif switch negative purifying selection nonhuman phylogeny physical chemistry positive selection priority journal protein assembly protein conformation protein expression protein function protein linear motif protein motif protein protein interaction protein secondary structure protein structure, function and variability purifying selection Pyrenophora regular expression regulatory evolution Review sequence alignment sequence analysis Simian virus 40 animal chemical structure chemistry genetics metabolism protein motif protein protein interaction Eukaryota Prokaryota Amino Acid Motifs Animals Evolution, Molecular Host-Pathogen Interactions Humans Models, Molecular Molecular Mimicry Protein Conformation Protein Interaction Maps Proteins Chemes, Lucía Beatriz de Prat Gay, Gonzalo Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| topic_facet |
retinoblastoma binding protein retinoblastoma protein protein adaptive evolution binding affinity coevolution convergent evolution evolutionary rate genetic conservation habitat selection Helicobacter host pathogen interaction host resistance human Human adenovirus 5 Human papillomavirus type 16 Leptospira linear motif mimicry Metapneumovirus molecular evolution molecular mimicry motif switch negative purifying selection nonhuman phylogeny physical chemistry positive selection priority journal protein assembly protein conformation protein expression protein function protein linear motif protein motif protein protein interaction protein secondary structure protein structure, function and variability purifying selection Pyrenophora regular expression regulatory evolution Review sequence alignment sequence analysis Simian virus 40 animal chemical structure chemistry genetics metabolism protein motif protein protein interaction Eukaryota Prokaryota Amino Acid Motifs Animals Evolution, Molecular Host-Pathogen Interactions Humans Models, Molecular Molecular Mimicry Protein Conformation Protein Interaction Maps Proteins |
| description |
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment. © 2015 Elsevier Ltd. |
| author |
Chemes, Lucía Beatriz de Prat Gay, Gonzalo |
| author_facet |
Chemes, Lucía Beatriz de Prat Gay, Gonzalo |
| author_sort |
Chemes, Lucía Beatriz |
| title |
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| title_short |
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| title_full |
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| title_fullStr |
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| title_full_unstemmed |
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| title_sort |
convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v32_n_p91_Chemes http://hdl.handle.net/20.500.12110/paper_0959440X_v32_n_p91_Chemes |
| work_keys_str_mv |
AT chemesluciabeatriz convergentevolutionandmimicryofproteinlinearmotifsinhostpathogeninteractions AT depratgaygonzalo convergentevolutionandmimicryofproteinlinearmotifsinhostpathogeninteractions |
| _version_ |
1768546077828448256 |