Functions of cell surface galectin-glycoprotein lattices

Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes wit...

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Autor principal:	Toscano, Marta Alicia
Publicado:	2007
Materias:	B lymphocyte receptor beta galactoside galectin glycoconjugate glycoprotein T lymphocyte receptor binding affinity cell activation cell death cell differentiation cell surface cell survival complex formation endocytosis glycosylation helper cell homeostasis host pathogen interaction immunocompetent cell nonhuman oyster priority journal protein carbohydrate interaction protein function protein protein interaction protein structure protein synthesis regulatory mechanism review signal transduction tandem repeat Animals B-Lymphocytes Cell Membrane Galectins Host-Pathogen Interactions Humans Immunity, Natural Membrane Glycoproteins Models, Molecular Multiprotein Complexes T-Lymphocytes Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v17_n5_p513_Rabinovich http://hdl.handle.net/20.500.12110/paper_0959440X_v17_n5_p513_Rabinovich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0959440X_v17_n5_p513_Rabinovich
record_format	dspace
spelling	paper:paper_0959440X_v17_n5_p513_Rabinovich2023-06-08T15:56:57Z Functions of cell surface galectin-glycoprotein lattices Toscano, Marta Alicia B lymphocyte receptor beta galactoside galectin glycoconjugate glycoprotein T lymphocyte receptor binding affinity cell activation cell death cell differentiation cell surface cell survival complex formation endocytosis glycosylation helper cell homeostasis host pathogen interaction immunocompetent cell nonhuman oyster priority journal protein carbohydrate interaction protein function protein protein interaction protein structure protein synthesis regulatory mechanism review signal transduction tandem repeat Animals B-Lymphocytes Cell Membrane Galectins Host-Pathogen Interactions Humans Immunity, Natural Membrane Glycoproteins Models, Molecular Multiprotein Complexes T-Lymphocytes Animalia Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival. Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of endogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis. © 2007 Elsevier Ltd. All rights reserved. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v17_n5_p513_Rabinovich http://hdl.handle.net/20.500.12110/paper_0959440X_v17_n5_p513_Rabinovich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	B lymphocyte receptor beta galactoside galectin glycoconjugate glycoprotein T lymphocyte receptor binding affinity cell activation cell death cell differentiation cell surface cell survival complex formation endocytosis glycosylation helper cell homeostasis host pathogen interaction immunocompetent cell nonhuman oyster priority journal protein carbohydrate interaction protein function protein protein interaction protein structure protein synthesis regulatory mechanism review signal transduction tandem repeat Animals B-Lymphocytes Cell Membrane Galectins Host-Pathogen Interactions Humans Immunity, Natural Membrane Glycoproteins Models, Molecular Multiprotein Complexes T-Lymphocytes Animalia
spellingShingle	B lymphocyte receptor beta galactoside galectin glycoconjugate glycoprotein T lymphocyte receptor binding affinity cell activation cell death cell differentiation cell surface cell survival complex formation endocytosis glycosylation helper cell homeostasis host pathogen interaction immunocompetent cell nonhuman oyster priority journal protein carbohydrate interaction protein function protein protein interaction protein structure protein synthesis regulatory mechanism review signal transduction tandem repeat Animals B-Lymphocytes Cell Membrane Galectins Host-Pathogen Interactions Humans Immunity, Natural Membrane Glycoproteins Models, Molecular Multiprotein Complexes T-Lymphocytes Animalia Toscano, Marta Alicia Functions of cell surface galectin-glycoprotein lattices
topic_facet	B lymphocyte receptor beta galactoside galectin glycoconjugate glycoprotein T lymphocyte receptor binding affinity cell activation cell death cell differentiation cell surface cell survival complex formation endocytosis glycosylation helper cell homeostasis host pathogen interaction immunocompetent cell nonhuman oyster priority journal protein carbohydrate interaction protein function protein protein interaction protein structure protein synthesis regulatory mechanism review signal transduction tandem repeat Animals B-Lymphocytes Cell Membrane Galectins Host-Pathogen Interactions Humans Immunity, Natural Membrane Glycoproteins Models, Molecular Multiprotein Complexes T-Lymphocytes Animalia
description	Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival. Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of endogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis. © 2007 Elsevier Ltd. All rights reserved.
author	Toscano, Marta Alicia
author_facet	Toscano, Marta Alicia
author_sort	Toscano, Marta Alicia
title	Functions of cell surface galectin-glycoprotein lattices
title_short	Functions of cell surface galectin-glycoprotein lattices
title_full	Functions of cell surface galectin-glycoprotein lattices
title_fullStr	Functions of cell surface galectin-glycoprotein lattices
title_full_unstemmed	Functions of cell surface galectin-glycoprotein lattices
title_sort	functions of cell surface galectin-glycoprotein lattices
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v17_n5_p513_Rabinovich http://hdl.handle.net/20.500.12110/paper_0959440X_v17_n5_p513_Rabinovich
work_keys_str_mv	AT toscanomartaalicia functionsofcellsurfacegalectinglycoproteinlattices
_version_	1768543093640921088

Functions of cell surface galectin-glycoprotein lattices

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