Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not a...
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| Autores principales: | , |
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1995
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v6_n4_p239_Villamil http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil |
| Aporte de: |
| Sumario: | Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay. |
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