Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin

Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not a...

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Autores principales:	Alche, Laura Edith, Coto, Celia Esther
Publicado:	1995
Materias:	Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v6_n4_p239_Villamil http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09563202_v6_n4_p239_Villamil
record_format	dspace
spelling	paper:paper_09563202_v6_n4_p239_Villamil2023-06-08T15:56:02Z Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin Alche, Laura Edith Coto, Celia Esther Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay. Fil:Alche, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v6_n4_p239_Villamil http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication
spellingShingle	Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication Alche, Laura Edith Coto, Celia Esther Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
topic_facet	Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication
description	Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay.
author	Alche, Laura Edith Coto, Celia Esther
author_facet	Alche, Laura Edith Coto, Celia Esther
author_sort	Alche, Laura Edith
title	Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_short	Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_full	Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_fullStr	Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_full_unstemmed	Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_sort	inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
publishDate	1995
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v6_n4_p239_Villamil http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
work_keys_str_mv	AT alchelauraedith inhibitionofherpessimplexvirustype1multiplicationbymeliacineapeptideofplantorigin AT cotoceliaesther inhibitionofherpessimplexvirustype1multiplicationbymeliacineapeptideofplantorigin
_version_	1768542229235761152

Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin

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