Promoter usage and alternative splicing

Recent findings justify a renewed interest in alternative splicing (AS): the process is more a rule than an exception as it affects the expression of 60% of human genes; it explains how a vast mammalian proteomic complexity is achieved with a limited number of genes; and mutations in AS regulatory s...

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Autor principal:	Kornblihtt, Alberto Rodolfo
Publicado:	2005
Materias:	messenger RNA peroxisome proliferator activated receptor gamma proteome RNA polymerase II steroid hormone WT1 protein alternative RNA splicing chromatin chromatin structure Cytomegalovirus DNA methylation exon gene expression gene mutation gene sequence genetic transcription intron isomerization mammal nonhuman oocyte phosphorylation polyadenylation priority journal promoter region review RNA processing RNA sequence RNA synthesis Saccharomyces cerevisiae spliceosome transcription initiation Xenopus Alternative Splicing Animals Humans Models, Biological Mutation Promoter Regions (Genetics) RNA Polymerase II RNA, Messenger Transcription Factors Transcription, Genetic Mammalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09550674_v17_n3_p262_Kornblihtt http://hdl.handle.net/20.500.12110/paper_09550674_v17_n3_p262_Kornblihtt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09550674_v17_n3_p262_Kornblihtt
record_format	dspace
spelling	paper:paper_09550674_v17_n3_p262_Kornblihtt2023-06-08T15:55:52Z Promoter usage and alternative splicing Kornblihtt, Alberto Rodolfo messenger RNA peroxisome proliferator activated receptor gamma proteome RNA polymerase II steroid hormone WT1 protein alternative RNA splicing chromatin chromatin structure Cytomegalovirus DNA methylation exon gene expression gene mutation gene sequence genetic transcription intron isomerization mammal nonhuman oocyte phosphorylation polyadenylation priority journal promoter region review RNA processing RNA sequence RNA synthesis Saccharomyces cerevisiae spliceosome transcription initiation Xenopus Alternative Splicing Animals Humans Models, Biological Mutation Promoter Regions (Genetics) RNA Polymerase II RNA, Messenger Saccharomyces cerevisiae Transcription Factors Transcription, Genetic Mammalia Recent findings justify a renewed interest in alternative splicing (AS): the process is more a rule than an exception as it affects the expression of 60% of human genes; it explains how a vast mammalian proteomic complexity is achieved with a limited number of genes; and mutations in AS regulatory sequences are a widespread source of human disease. AS regulation not only depends on the interaction of splicing factors with their target sequences in the pre-mRNA but is coupled to transcription. A clearer picture is emerging of the mechanisms by which transcription affects AS through promoter identity and occupation. These mechanisms involve the recruitment of factors with dual functions in transcription and splicing (i.e. that contain both functional domains and hence link the two processes) and the control of RNA polymerase II elongation. © 2005 Elsevier Ltd. All rights reserved. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09550674_v17_n3_p262_Kornblihtt http://hdl.handle.net/20.500.12110/paper_09550674_v17_n3_p262_Kornblihtt
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	messenger RNA peroxisome proliferator activated receptor gamma proteome RNA polymerase II steroid hormone WT1 protein alternative RNA splicing chromatin chromatin structure Cytomegalovirus DNA methylation exon gene expression gene mutation gene sequence genetic transcription intron isomerization mammal nonhuman oocyte phosphorylation polyadenylation priority journal promoter region review RNA processing RNA sequence RNA synthesis Saccharomyces cerevisiae spliceosome transcription initiation Xenopus Alternative Splicing Animals Humans Models, Biological Mutation Promoter Regions (Genetics) RNA Polymerase II RNA, Messenger Saccharomyces cerevisiae Transcription Factors Transcription, Genetic Mammalia
spellingShingle	messenger RNA peroxisome proliferator activated receptor gamma proteome RNA polymerase II steroid hormone WT1 protein alternative RNA splicing chromatin chromatin structure Cytomegalovirus DNA methylation exon gene expression gene mutation gene sequence genetic transcription intron isomerization mammal nonhuman oocyte phosphorylation polyadenylation priority journal promoter region review RNA processing RNA sequence RNA synthesis Saccharomyces cerevisiae spliceosome transcription initiation Xenopus Alternative Splicing Animals Humans Models, Biological Mutation Promoter Regions (Genetics) RNA Polymerase II RNA, Messenger Saccharomyces cerevisiae Transcription Factors Transcription, Genetic Mammalia Kornblihtt, Alberto Rodolfo Promoter usage and alternative splicing
topic_facet	messenger RNA peroxisome proliferator activated receptor gamma proteome RNA polymerase II steroid hormone WT1 protein alternative RNA splicing chromatin chromatin structure Cytomegalovirus DNA methylation exon gene expression gene mutation gene sequence genetic transcription intron isomerization mammal nonhuman oocyte phosphorylation polyadenylation priority journal promoter region review RNA processing RNA sequence RNA synthesis Saccharomyces cerevisiae spliceosome transcription initiation Xenopus Alternative Splicing Animals Humans Models, Biological Mutation Promoter Regions (Genetics) RNA Polymerase II RNA, Messenger Saccharomyces cerevisiae Transcription Factors Transcription, Genetic Mammalia
description	Recent findings justify a renewed interest in alternative splicing (AS): the process is more a rule than an exception as it affects the expression of 60% of human genes; it explains how a vast mammalian proteomic complexity is achieved with a limited number of genes; and mutations in AS regulatory sequences are a widespread source of human disease. AS regulation not only depends on the interaction of splicing factors with their target sequences in the pre-mRNA but is coupled to transcription. A clearer picture is emerging of the mechanisms by which transcription affects AS through promoter identity and occupation. These mechanisms involve the recruitment of factors with dual functions in transcription and splicing (i.e. that contain both functional domains and hence link the two processes) and the control of RNA polymerase II elongation. © 2005 Elsevier Ltd. All rights reserved.
author	Kornblihtt, Alberto Rodolfo
author_facet	Kornblihtt, Alberto Rodolfo
author_sort	Kornblihtt, Alberto Rodolfo
title	Promoter usage and alternative splicing
title_short	Promoter usage and alternative splicing
title_full	Promoter usage and alternative splicing
title_fullStr	Promoter usage and alternative splicing
title_full_unstemmed	Promoter usage and alternative splicing
title_sort	promoter usage and alternative splicing
publishDate	2005
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09550674_v17_n3_p262_Kornblihtt http://hdl.handle.net/20.500.12110/paper_09550674_v17_n3_p262_Kornblihtt
work_keys_str_mv	AT kornblihttalbertorodolfo promoterusageandalternativesplicing
_version_	1768545472305168384

Promoter usage and alternative splicing

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