Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats
In previous studies we have shown that the developing rat provides an interesting physiologic model in which the dopaminergic control of both LH and FSH is well defined in contrast to the controversial results obtained in adult rats. We wished to establish the role of testosterone in antidopaminergi...
Guardado en:
| Publicado: |
1993
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09538194_v5_n6_p705_Lacau‐Mengido http://hdl.handle.net/20.500.12110/paper_09538194_v5_n6_p705_Lacau‐Mengido |
| Aporte de: |
| id |
paper:paper_09538194_v5_n6_p705_LacauâÂÂMengido |
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| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antidopaminergic drugs development FSH LH LHRH bromocriptine domperidone dopamine receptor dopamine receptor blocking agent follitropin gonadorelin gonadotropin haloperidol luteinizing hormone phentolamine phentolamine mesylate testosterone testosterone propionate adenohypophysis age animal cell animal experiment animal tissue article controlled study dopaminergic system female follitropin release gonadorelin release gonadotropin release hormone action hypophysis hypophysis cell hypothalamus intraperitoneal drug administration luteinizing hormone release male nonhuman orchiectomy ovariectomy postnatal development preoptic area priority journal rat suprachiasmatic nucleus testosterone blood level Adrenergic alpha-Antagonists Animal Animals, Newborn Bromocriptine Cells, Cultured Dopamine Antagonists Female Follicle Stimulating Hormone Gonadorelin Haloperidol Hypothalamus In Vitro Luteinizing Hormone Male Orchiectomy Phentolamine Pituitary Gland Rats Rats, Sprague-Dawley Sex Differentiation Stimulation, Chemical Support, Non-U.S. Gov't |
| spellingShingle |
antidopaminergic drugs development FSH LH LHRH bromocriptine domperidone dopamine receptor dopamine receptor blocking agent follitropin gonadorelin gonadotropin haloperidol luteinizing hormone phentolamine phentolamine mesylate testosterone testosterone propionate adenohypophysis age animal cell animal experiment animal tissue article controlled study dopaminergic system female follitropin release gonadorelin release gonadotropin release hormone action hypophysis hypophysis cell hypothalamus intraperitoneal drug administration luteinizing hormone release male nonhuman orchiectomy ovariectomy postnatal development preoptic area priority journal rat suprachiasmatic nucleus testosterone blood level Adrenergic alpha-Antagonists Animal Animals, Newborn Bromocriptine Cells, Cultured Dopamine Antagonists Female Follicle Stimulating Hormone Gonadorelin Haloperidol Hypothalamus In Vitro Luteinizing Hormone Male Orchiectomy Phentolamine Pituitary Gland Rats Rats, Sprague-Dawley Sex Differentiation Stimulation, Chemical Support, Non-U.S. Gov't Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| topic_facet |
antidopaminergic drugs development FSH LH LHRH bromocriptine domperidone dopamine receptor dopamine receptor blocking agent follitropin gonadorelin gonadotropin haloperidol luteinizing hormone phentolamine phentolamine mesylate testosterone testosterone propionate adenohypophysis age animal cell animal experiment animal tissue article controlled study dopaminergic system female follitropin release gonadorelin release gonadotropin release hormone action hypophysis hypophysis cell hypothalamus intraperitoneal drug administration luteinizing hormone release male nonhuman orchiectomy ovariectomy postnatal development preoptic area priority journal rat suprachiasmatic nucleus testosterone blood level Adrenergic alpha-Antagonists Animal Animals, Newborn Bromocriptine Cells, Cultured Dopamine Antagonists Female Follicle Stimulating Hormone Gonadorelin Haloperidol Hypothalamus In Vitro Luteinizing Hormone Male Orchiectomy Phentolamine Pituitary Gland Rats Rats, Sprague-Dawley Sex Differentiation Stimulation, Chemical Support, Non-U.S. Gov't |
| description |
In previous studies we have shown that the developing rat provides an interesting physiologic model in which the dopaminergic control of both LH and FSH is well defined in contrast to the controversial results obtained in adult rats. We wished to establish the role of testosterone in antidopaminergic induced gonadotrophins release in 12 day‐old male and female rats, and evaluate the effect of antidopaminergic drugs at the hypothalamic level during this developmental stage. Haloperidol, an antidopaminergic drug, increased both LH and FSH in female 12 day‐old rats but not in male littermates. The effect was blocked by bromocriptine and not by phentolamine indicating that haloperidol acted on the dopaminergic receptor, and that unspecific stimulation of the noradrenergic system was not involved. Haloperidol was ineffective when female rats were previously ovariectomized and injected with testosterone propionate at 9 days of age. If females were treated on the day of birth with testosterone propionate, haloperidol‐induced FSH and LH release was also abolished. In control males haloperidol had no effect on the release of LH or FSH. But if males were orchidectomized at birth or at 9 days of age, haloperidol released both LH and FSH during the infantile period. In an attempt to establish the site of action of antidopaminergic drugs on gonadotrophin release, hypothalami (mediobasal and preoptic‐suprachiasmatic area) from 12 day‐old infant female rats were perfused with either haloperidol or domperidone (2±10−6 M). Both drugs increased LHRH release into the perifusate. Besides haloperidol did not modify the release of LH or FSH from adenohypophyseal cells incubated in vitro. We therefore conclude that antidopaminergic‐induced gonadotrophins release is modulated by serum testosterone concentrations, and that the site of action is probably the LHRH‐secreting neuron of the hypothalamus. Copyright © 1993, Wiley Blackwell. All rights reserved |
| title |
Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| title_short |
Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| title_full |
Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| title_fullStr |
Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| title_full_unstemmed |
Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats |
| title_sort |
antidopaminergic‐lnduced hypothalamic lhrh release and pituitary gonadotrophin secretion in 12 day‐old female and male rats |
| publishDate |
1993 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09538194_v5_n6_p705_Lacau‐Mengido http://hdl.handle.net/20.500.12110/paper_09538194_v5_n6_p705_Lacau‐Mengido |
| bdutipo_str |
Repositorios |
| _version_ |
1764820564565819392 |