The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata

There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is consider...

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Autor principal:	Pedreira, Maria Eugenia
Publicado:	2013
Materias:	Associative learning Extinction memory GABA Invertebrate animal experiment animal model anticipation article aversive behavior cognition conditioning controlled study crab extinction memory GABAergic system GABAergic transmission information retrieval locomotion male memory memory consolidation Neohelice granulata neurobiology neurotransmission nonhuman priority journal protein analysis protein expression protein function associative learning invertebrate Animals Bicuculline Brachyura Conditioning, Classical Extinction, Psychological GABA-A Receptor Agonists GABA-A Receptor Antagonists Memory Muscimol
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v38_n9_p3302_Tano http://hdl.handle.net/20.500.12110/paper_0953816X_v38_n9_p3302_Tano
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0953816X_v38_n9_p3302_Tano
record_format	dspace
spelling	paper:paper_0953816X_v38_n9_p3302_Tano2023-06-08T15:55:32Z The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata Pedreira, Maria Eugenia Associative learning Extinction memory GABA Invertebrate animal experiment animal model anticipation article aversive behavior cognition conditioning controlled study crab extinction memory GABAergic system GABAergic transmission information retrieval locomotion male memory memory consolidation Neohelice granulata neurobiology neurotransmission nonhuman priority journal protein analysis protein expression protein function associative learning extinction memory GABA invertebrate Animals Bicuculline Brachyura Conditioning, Classical Extinction, Psychological GABA-A Receptor Agonists GABA-A Receptor Antagonists Memory Muscimol There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v38_n9_p3302_Tano http://hdl.handle.net/20.500.12110/paper_0953816X_v38_n9_p3302_Tano
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Associative learning Extinction memory GABA Invertebrate animal experiment animal model anticipation article aversive behavior cognition conditioning controlled study crab extinction memory GABAergic system GABAergic transmission information retrieval locomotion male memory memory consolidation Neohelice granulata neurobiology neurotransmission nonhuman priority journal protein analysis protein expression protein function associative learning extinction memory GABA invertebrate Animals Bicuculline Brachyura Conditioning, Classical Extinction, Psychological GABA-A Receptor Agonists GABA-A Receptor Antagonists Memory Muscimol
spellingShingle	Associative learning Extinction memory GABA Invertebrate animal experiment animal model anticipation article aversive behavior cognition conditioning controlled study crab extinction memory GABAergic system GABAergic transmission information retrieval locomotion male memory memory consolidation Neohelice granulata neurobiology neurotransmission nonhuman priority journal protein analysis protein expression protein function associative learning extinction memory GABA invertebrate Animals Bicuculline Brachyura Conditioning, Classical Extinction, Psychological GABA-A Receptor Agonists GABA-A Receptor Antagonists Memory Muscimol Pedreira, Maria Eugenia The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
topic_facet	Associative learning Extinction memory GABA Invertebrate animal experiment animal model anticipation article aversive behavior cognition conditioning controlled study crab extinction memory GABAergic system GABAergic transmission information retrieval locomotion male memory memory consolidation Neohelice granulata neurobiology neurotransmission nonhuman priority journal protein analysis protein expression protein function associative learning extinction memory GABA invertebrate Animals Bicuculline Brachyura Conditioning, Classical Extinction, Psychological GABA-A Receptor Agonists GABA-A Receptor Antagonists Memory Muscimol
description	There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
author	Pedreira, Maria Eugenia
author_facet	Pedreira, Maria Eugenia
author_sort	Pedreira, Maria Eugenia
title	The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_short	The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_full	The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_fullStr	The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_full_unstemmed	The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_sort	involvement of the gabaergic system in the formation and expression of the extinction memory in the crab neohelice granulata
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v38_n9_p3302_Tano http://hdl.handle.net/20.500.12110/paper_0953816X_v38_n9_p3302_Tano
work_keys_str_mv	AT pedreiramariaeugenia theinvolvementofthegabaergicsystemintheformationandexpressionoftheextinctionmemoryinthecrabneohelicegranulata AT pedreiramariaeugenia involvementofthegabaergicsystemintheformationandexpressionoftheextinctionmemoryinthecrabneohelicegranulata
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The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata

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