Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus
Ample evidence suggests that, when reactivated by a reminder, a consolidated memory may return to a labile state and needs to be stabilized again in order to persist, a process known as reconsolidation. In a previous study, performed in the crab Chasmagnathus, we found a dual role for the biogenic a...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v34_n7_p1170_Kaczer http://hdl.handle.net/20.500.12110/paper_0953816X_v34_n7_p1170_Kaczer |
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paper:paper_0953816X_v34_n7_p1170_Kaczer2023-06-08T15:55:31Z Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus Kaczer, Laura Klappenbach, Martin Appetitive conditioning Aversive conditioning Biogenic amine Invertebrates Memory reconsolidation octopamine animal experiment appetitive memory article aversive memory Chasmagnathus conditioning controlled study crab information retrieval male memory memory consolidation neurochemistry nonhuman priority journal protein synthesis reinforcement sequence homology signal transduction Adrenergic alpha-Agonists Animals Association Learning Brachyura Male Memory Octopamine Ample evidence suggests that, when reactivated by a reminder, a consolidated memory may return to a labile state and needs to be stabilized again in order to persist, a process known as reconsolidation. In a previous study, performed in the crab Chasmagnathus, we found a dual role for the biogenic amine octopamine (OA) during memory consolidation. On the one hand, it was necessary for appetitive memory formation and, on the other, it had a deleterious effect on aversive memory consolidation. Thus, OA could be a good candidate to dissect the neurochemical mechanisms of appetitive and aversive reconsolidation. Here, we initially characterized the reconsolidation of an appetitive memory. Then, we compared appetitive reconsolidation with its aversive counterpart regarding the implication of OA in these processes, and contrasted them with previous findings obtained in the consolidation phase. Our results demonstrate that appetitive reconsolidation takes place when animals are re-exposed to the training context, as shown by the amnesic effect of cycloheximide when applied before the reminder. In addition, the no-reinforcement during the reminder is a necessary condition for appetitive reconsolidation to occur. Remarkably, appetitive reconsolidation is neither impaired by OA receptor antagonists nor facilitated by exogenous OA, whereas aversive reconsolidation can be interfered with by OA administration. Thus, our results indicate that appetitive reconsolidation does not involve OA signaling, while aversive reconsolidation is negatively modulated by OA. All in all, these results could constitute a step towards the identification of particular features of appetitive and aversive reconsolidation. © 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. Fil:Kaczer, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Klappenbach, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v34_n7_p1170_Kaczer http://hdl.handle.net/20.500.12110/paper_0953816X_v34_n7_p1170_Kaczer |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Appetitive conditioning Aversive conditioning Biogenic amine Invertebrates Memory reconsolidation octopamine animal experiment appetitive memory article aversive memory Chasmagnathus conditioning controlled study crab information retrieval male memory memory consolidation neurochemistry nonhuman priority journal protein synthesis reinforcement sequence homology signal transduction Adrenergic alpha-Agonists Animals Association Learning Brachyura Male Memory Octopamine |
| spellingShingle |
Appetitive conditioning Aversive conditioning Biogenic amine Invertebrates Memory reconsolidation octopamine animal experiment appetitive memory article aversive memory Chasmagnathus conditioning controlled study crab information retrieval male memory memory consolidation neurochemistry nonhuman priority journal protein synthesis reinforcement sequence homology signal transduction Adrenergic alpha-Agonists Animals Association Learning Brachyura Male Memory Octopamine Kaczer, Laura Klappenbach, Martin Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| topic_facet |
Appetitive conditioning Aversive conditioning Biogenic amine Invertebrates Memory reconsolidation octopamine animal experiment appetitive memory article aversive memory Chasmagnathus conditioning controlled study crab information retrieval male memory memory consolidation neurochemistry nonhuman priority journal protein synthesis reinforcement sequence homology signal transduction Adrenergic alpha-Agonists Animals Association Learning Brachyura Male Memory Octopamine |
| description |
Ample evidence suggests that, when reactivated by a reminder, a consolidated memory may return to a labile state and needs to be stabilized again in order to persist, a process known as reconsolidation. In a previous study, performed in the crab Chasmagnathus, we found a dual role for the biogenic amine octopamine (OA) during memory consolidation. On the one hand, it was necessary for appetitive memory formation and, on the other, it had a deleterious effect on aversive memory consolidation. Thus, OA could be a good candidate to dissect the neurochemical mechanisms of appetitive and aversive reconsolidation. Here, we initially characterized the reconsolidation of an appetitive memory. Then, we compared appetitive reconsolidation with its aversive counterpart regarding the implication of OA in these processes, and contrasted them with previous findings obtained in the consolidation phase. Our results demonstrate that appetitive reconsolidation takes place when animals are re-exposed to the training context, as shown by the amnesic effect of cycloheximide when applied before the reminder. In addition, the no-reinforcement during the reminder is a necessary condition for appetitive reconsolidation to occur. Remarkably, appetitive reconsolidation is neither impaired by OA receptor antagonists nor facilitated by exogenous OA, whereas aversive reconsolidation can be interfered with by OA administration. Thus, our results indicate that appetitive reconsolidation does not involve OA signaling, while aversive reconsolidation is negatively modulated by OA. All in all, these results could constitute a step towards the identification of particular features of appetitive and aversive reconsolidation. © 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. |
| author |
Kaczer, Laura Klappenbach, Martin |
| author_facet |
Kaczer, Laura Klappenbach, Martin |
| author_sort |
Kaczer, Laura |
| title |
Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| title_short |
Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| title_full |
Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| title_fullStr |
Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| title_full_unstemmed |
Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus |
| title_sort |
dissecting mechanisms of reconsolidation: octopamine reveals differences between appetitive and aversive memories in the crab chasmagnathus |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v34_n7_p1170_Kaczer http://hdl.handle.net/20.500.12110/paper_0953816X_v34_n7_p1170_Kaczer |
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AT kaczerlaura dissectingmechanismsofreconsolidationoctopaminerevealsdifferencesbetweenappetitiveandaversivememoriesinthecrabchasmagnathus AT klappenbachmartin dissectingmechanismsofreconsolidationoctopaminerevealsdifferencesbetweenappetitiveandaversivememoriesinthecrabchasmagnathus |
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1768544283373076480 |