Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory
NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memo...
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2006
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v24_n6_p1507_Romano http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano |
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paper:paper_0953816X_v24_n6_p1507_Romano2023-06-08T15:55:29Z Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Merlo, Emiliano Gene expression Long-term memory Synaptic plasticity immunoglobulin enhancer binding protein transcription factor cell nucleus gene expression regulation genetic transcription invertebrate knockout mouse long term memory mammal nerve cell plasticity nonhuman priority journal protein function review signal transduction synapse Animals Biological Evolution Evolution Gene Expression Humans Memory Models, Biological Neuronal Plasticity NF-kappa B NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memory processing, and is activated by signals such as glutamate and Ca 2+, its role in neural plasticity and memory has only recently become apparent. A surprising feature of this molecule is its presence within the synapse. An increasing number of reports have called attention to the role of this TF in processes that require long-term regulation of the synaptic function underlying memory and neural plasticity. Here we review the evidence regarding a dual role for NF-κB, as both a signalling molecule after its activation at the synapse and a transcriptional regulator upon reaching the nucleus. The specific role of this signal, as well as the general transcriptional mechanism, in the process of memory formation is discussed. Converging lines of evidence summarized here point to a pivotal role for the NF-κB transcription factor as a direct signalling mechanism in the regulation of gene expression involved in long-term memory. © The Authors (2006). Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Merlo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v24_n6_p1507_Romano http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Gene expression Long-term memory Synaptic plasticity immunoglobulin enhancer binding protein transcription factor cell nucleus gene expression regulation genetic transcription invertebrate knockout mouse long term memory mammal nerve cell plasticity nonhuman priority journal protein function review signal transduction synapse Animals Biological Evolution Evolution Gene Expression Humans Memory Models, Biological Neuronal Plasticity NF-kappa B |
| spellingShingle |
Gene expression Long-term memory Synaptic plasticity immunoglobulin enhancer binding protein transcription factor cell nucleus gene expression regulation genetic transcription invertebrate knockout mouse long term memory mammal nerve cell plasticity nonhuman priority journal protein function review signal transduction synapse Animals Biological Evolution Evolution Gene Expression Humans Memory Models, Biological Neuronal Plasticity NF-kappa B Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Merlo, Emiliano Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| topic_facet |
Gene expression Long-term memory Synaptic plasticity immunoglobulin enhancer binding protein transcription factor cell nucleus gene expression regulation genetic transcription invertebrate knockout mouse long term memory mammal nerve cell plasticity nonhuman priority journal protein function review signal transduction synapse Animals Biological Evolution Evolution Gene Expression Humans Memory Models, Biological Neuronal Plasticity NF-kappa B |
| description |
NF-κB is an evolutionarily conserved family of transcription factors (TFs) critically involved in basic cellular mechanisms of the immune response, inflammation, development and apoptosis. In spite of the fact that it is expressed in the central nervous system, particularly in areas involved in memory processing, and is activated by signals such as glutamate and Ca 2+, its role in neural plasticity and memory has only recently become apparent. A surprising feature of this molecule is its presence within the synapse. An increasing number of reports have called attention to the role of this TF in processes that require long-term regulation of the synaptic function underlying memory and neural plasticity. Here we review the evidence regarding a dual role for NF-κB, as both a signalling molecule after its activation at the synapse and a transcriptional regulator upon reaching the nucleus. The specific role of this signal, as well as the general transcriptional mechanism, in the process of memory formation is discussed. Converging lines of evidence summarized here point to a pivotal role for the NF-κB transcription factor as a direct signalling mechanism in the regulation of gene expression involved in long-term memory. © The Authors (2006). |
| author |
Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Merlo, Emiliano |
| author_facet |
Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Merlo, Emiliano |
| author_sort |
Romano, Arturo Gabriel |
| title |
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| title_short |
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| title_full |
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| title_fullStr |
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| title_full_unstemmed |
Evolutionarily-conserved role of the NF-κB transcription factor in neural plasticity and memory |
| title_sort |
evolutionarily-conserved role of the nf-κb transcription factor in neural plasticity and memory |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v24_n6_p1507_Romano http://hdl.handle.net/20.500.12110/paper_0953816X_v24_n6_p1507_Romano |
| work_keys_str_mv |
AT romanoarturogabriel evolutionarilyconservedroleofthenfkbtranscriptionfactorinneuralplasticityandmemory AT freudenthalramiroangelmaria evolutionarilyconservedroleofthenfkbtranscriptionfactorinneuralplasticityandmemory AT merloemiliano evolutionarilyconservedroleofthenfkbtranscriptionfactorinneuralplasticityandmemory |
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1768541619301122048 |