Programmed cell senescence: Role of IL-6 in the pituitary
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, depending on the cellular context. IL-6, as do other cytokines, plays impor...
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09525041_v58_n4_pR241_Sapochnik http://hdl.handle.net/20.500.12110/paper_09525041_v58_n4_pR241_Sapochnik |
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paper:paper_09525041_v58_n4_pR241_Sapochnik2023-06-08T15:55:03Z Programmed cell senescence: Role of IL-6 in the pituitary Autocrine IL-6 Pituitary tumor Senescence interleukin 6 IL6 protein, human interleukin 6 mitogen activated protein kinase kinase phosphatidylinositol 3 kinase STAT protein carcinogenesis cell aging cell growth human hypophysis hypophysis adenoma hypophysis cell hypophysis tumor malignant transformation molecular pathology nonhuman paracrine signaling priority journal protein function Review adenohypophysis adenoma animal autocrine effect cell aging cell cycle cell proliferation extracellular matrix gene expression regulation genetics metabolism neovascularization (pathology) pathology Adenoma Animals Autocrine Communication Cell Cycle Cell Proliferation Cellular Senescence Extracellular Matrix Gene Expression Regulation Humans Interleukin-6 Mitogen-Activated Protein Kinase Kinases Neovascularization, Pathologic Paracrine Communication Phosphatidylinositol 3-Kinases Pituitary Gland, Anterior Pituitary Neoplasms STAT Transcription Factors IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, depending on the cellular context. IL-6, as do other cytokines, plays important roles in the function, growth and neuroendocrine responses of the anterior pituitary gland. The multiple actions of IL-6 on normal and adenomatous pituitary function, cell proliferation, angiogenesis and extracellular matrix remodeling indicate its importance in the regulation of the anterior pituitary. Pituitary tumors are mostly benign adenomas with low mitotic index and rarely became malignant. Premature senescence occurs in slow-growing benign tumors, like pituitary adenomas. The dual role of IL-6 in senescence and tumorigenesis is well represented in pituitary tumor development, as it has been demonstrated that effects of paracrine IL-6 may allow initial pituitary cell growth, whereas autocrine IL-6 in the same tumor triggers senescence and restrains aggressive growth and malignant transformation. IL-6 is instrumental in promotion and maintenance of the senescence program in pituitary adenomas. © 2017 Society for Endocrinology. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09525041_v58_n4_pR241_Sapochnik http://hdl.handle.net/20.500.12110/paper_09525041_v58_n4_pR241_Sapochnik |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autocrine IL-6 Pituitary tumor Senescence interleukin 6 IL6 protein, human interleukin 6 mitogen activated protein kinase kinase phosphatidylinositol 3 kinase STAT protein carcinogenesis cell aging cell growth human hypophysis hypophysis adenoma hypophysis cell hypophysis tumor malignant transformation molecular pathology nonhuman paracrine signaling priority journal protein function Review adenohypophysis adenoma animal autocrine effect cell aging cell cycle cell proliferation extracellular matrix gene expression regulation genetics metabolism neovascularization (pathology) pathology Adenoma Animals Autocrine Communication Cell Cycle Cell Proliferation Cellular Senescence Extracellular Matrix Gene Expression Regulation Humans Interleukin-6 Mitogen-Activated Protein Kinase Kinases Neovascularization, Pathologic Paracrine Communication Phosphatidylinositol 3-Kinases Pituitary Gland, Anterior Pituitary Neoplasms STAT Transcription Factors |
| spellingShingle |
Autocrine IL-6 Pituitary tumor Senescence interleukin 6 IL6 protein, human interleukin 6 mitogen activated protein kinase kinase phosphatidylinositol 3 kinase STAT protein carcinogenesis cell aging cell growth human hypophysis hypophysis adenoma hypophysis cell hypophysis tumor malignant transformation molecular pathology nonhuman paracrine signaling priority journal protein function Review adenohypophysis adenoma animal autocrine effect cell aging cell cycle cell proliferation extracellular matrix gene expression regulation genetics metabolism neovascularization (pathology) pathology Adenoma Animals Autocrine Communication Cell Cycle Cell Proliferation Cellular Senescence Extracellular Matrix Gene Expression Regulation Humans Interleukin-6 Mitogen-Activated Protein Kinase Kinases Neovascularization, Pathologic Paracrine Communication Phosphatidylinositol 3-Kinases Pituitary Gland, Anterior Pituitary Neoplasms STAT Transcription Factors Programmed cell senescence: Role of IL-6 in the pituitary |
| topic_facet |
Autocrine IL-6 Pituitary tumor Senescence interleukin 6 IL6 protein, human interleukin 6 mitogen activated protein kinase kinase phosphatidylinositol 3 kinase STAT protein carcinogenesis cell aging cell growth human hypophysis hypophysis adenoma hypophysis cell hypophysis tumor malignant transformation molecular pathology nonhuman paracrine signaling priority journal protein function Review adenohypophysis adenoma animal autocrine effect cell aging cell cycle cell proliferation extracellular matrix gene expression regulation genetics metabolism neovascularization (pathology) pathology Adenoma Animals Autocrine Communication Cell Cycle Cell Proliferation Cellular Senescence Extracellular Matrix Gene Expression Regulation Humans Interleukin-6 Mitogen-Activated Protein Kinase Kinases Neovascularization, Pathologic Paracrine Communication Phosphatidylinositol 3-Kinases Pituitary Gland, Anterior Pituitary Neoplasms STAT Transcription Factors |
| description |
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, depending on the cellular context. IL-6, as do other cytokines, plays important roles in the function, growth and neuroendocrine responses of the anterior pituitary gland. The multiple actions of IL-6 on normal and adenomatous pituitary function, cell proliferation, angiogenesis and extracellular matrix remodeling indicate its importance in the regulation of the anterior pituitary. Pituitary tumors are mostly benign adenomas with low mitotic index and rarely became malignant. Premature senescence occurs in slow-growing benign tumors, like pituitary adenomas. The dual role of IL-6 in senescence and tumorigenesis is well represented in pituitary tumor development, as it has been demonstrated that effects of paracrine IL-6 may allow initial pituitary cell growth, whereas autocrine IL-6 in the same tumor triggers senescence and restrains aggressive growth and malignant transformation. IL-6 is instrumental in promotion and maintenance of the senescence program in pituitary adenomas. © 2017 Society for Endocrinology. |
| title |
Programmed cell senescence: Role of IL-6 in the pituitary |
| title_short |
Programmed cell senescence: Role of IL-6 in the pituitary |
| title_full |
Programmed cell senescence: Role of IL-6 in the pituitary |
| title_fullStr |
Programmed cell senescence: Role of IL-6 in the pituitary |
| title_full_unstemmed |
Programmed cell senescence: Role of IL-6 in the pituitary |
| title_sort |
programmed cell senescence: role of il-6 in the pituitary |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09525041_v58_n4_pR241_Sapochnik http://hdl.handle.net/20.500.12110/paper_09525041_v58_n4_pR241_Sapochnik |
| _version_ |
1768546356089061376 |