Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin

The effects of electric field stimulation (EFS) on the outputs of prostaglandins (PGs) E1, E2 and F2α from isolated contracting rat urinary bladders, were explored. Also, the influences of papaverine (5.10-6 M) and of tetradotoxin (TTX = 5.10-7 M) on PGs released by spontaneously contracting or elec...

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Publicado:	1989
Materias:	papaverine prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha tetrodotoxin animal cell bladder nonhuman priority journal rat Alprostadil Animal Bladder Dinoprost Dinoprostone Electric Stimulation Female In Vitro Muscle Contraction Papaverine Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Synaptic Transmission Tetrodotoxin
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v36_n2_p65_Dveksler http://hdl.handle.net/20.500.12110/paper_09523278_v36_n2_p65_Dveksler
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09523278_v36_n2_p65_Dveksler
record_format	dspace
spelling	paper:paper_09523278_v36_n2_p65_Dveksler2023-06-08T15:55:01Z Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin papaverine prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha tetrodotoxin animal cell bladder nonhuman priority journal rat Alprostadil Animal Bladder Dinoprost Dinoprostone Electric Stimulation Female In Vitro Muscle Contraction Papaverine Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Synaptic Transmission Tetrodotoxin The effects of electric field stimulation (EFS) on the outputs of prostaglandins (PGs) E1, E2 and F2α from isolated contracting rat urinary bladders, were explored. Also, the influences of papaverine (5.10-6 M) and of tetradotoxin (TTX = 5.10-7 M) on PGs released by spontaneously contracting or electrically driven preparations, were tested. The basal control outputs of the three PGs in spontaneously contracting urinary bladders, had a comparable magnitude. On the contrary, in electrically stimulated preparations the output of PGE2 rose significantly; that of PGF2α presented a significant reduction and the release of PGE1 was similar to that in controls. Papaverine failed to modify the profile of basal control PG release in non-stimulated bladders, abolished contractile responses to EFS and blocked the augmented output of PGE2 elicited by EFS. The presence of TTX in the suspending solution had no action on the basal control release of PGs from non-stimulated spontaneously contracting preparations, depressed between 80-90% the inotropic responses triggered by EFS and completely antagonized the enhanced output of PGE2 evoked by EFS. Results are discussed in terms of the relative participations of the evoked inotropism of the detrusor muscle or by the stimulation of nerve endings, accounting for the greater release of tissue PGE2 after EFS. © 1989. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v36_n2_p65_Dveksler http://hdl.handle.net/20.500.12110/paper_09523278_v36_n2_p65_Dveksler
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	papaverine prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha tetrodotoxin animal cell bladder nonhuman priority journal rat Alprostadil Animal Bladder Dinoprost Dinoprostone Electric Stimulation Female In Vitro Muscle Contraction Papaverine Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Synaptic Transmission Tetrodotoxin
spellingShingle	papaverine prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha tetrodotoxin animal cell bladder nonhuman priority journal rat Alprostadil Animal Bladder Dinoprost Dinoprostone Electric Stimulation Female In Vitro Muscle Contraction Papaverine Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Synaptic Transmission Tetrodotoxin Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
topic_facet	papaverine prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha tetrodotoxin animal cell bladder nonhuman priority journal rat Alprostadil Animal Bladder Dinoprost Dinoprostone Electric Stimulation Female In Vitro Muscle Contraction Papaverine Prostaglandins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Synaptic Transmission Tetrodotoxin
description	The effects of electric field stimulation (EFS) on the outputs of prostaglandins (PGs) E1, E2 and F2α from isolated contracting rat urinary bladders, were explored. Also, the influences of papaverine (5.10-6 M) and of tetradotoxin (TTX = 5.10-7 M) on PGs released by spontaneously contracting or electrically driven preparations, were tested. The basal control outputs of the three PGs in spontaneously contracting urinary bladders, had a comparable magnitude. On the contrary, in electrically stimulated preparations the output of PGE2 rose significantly; that of PGF2α presented a significant reduction and the release of PGE1 was similar to that in controls. Papaverine failed to modify the profile of basal control PG release in non-stimulated bladders, abolished contractile responses to EFS and blocked the augmented output of PGE2 elicited by EFS. The presence of TTX in the suspending solution had no action on the basal control release of PGs from non-stimulated spontaneously contracting preparations, depressed between 80-90% the inotropic responses triggered by EFS and completely antagonized the enhanced output of PGE2 evoked by EFS. Results are discussed in terms of the relative participations of the evoked inotropism of the detrusor muscle or by the stimulation of nerve endings, accounting for the greater release of tissue PGE2 after EFS. © 1989.
title	Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
title_short	Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
title_full	Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
title_fullStr	Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
title_full_unstemmed	Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
title_sort	electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. influences of papaverine and tetradotoxin
publishDate	1989
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v36_n2_p65_Dveksler http://hdl.handle.net/20.500.12110/paper_09523278_v36_n2_p65_Dveksler
_version_	1768544283182235648

Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin

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