Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

In an effort to gain an understanding of the processes governing ultraviolet matrix-assisted laser desorption/ionization (UV-MALDI), direct comparison was made of the mass spectra of proteins, carbohydrates and synthetic polymers (polyethylene glycol, polyester and polyamide) by using pyridylindoles...

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Autor principal:	Erra Balsells, Rosa
Publicado:	2001
Materias:	2,5-dihydroxybenzoic acid bipyridine derivative carbohydrate carboline derivative cyclodextrin gentisic acid harman harmine hydrogen hydroxybenzoic acid derivative indole derivative maneb nitrogen polymer protein pyridine derivative pyrifenox mancozeb pyrifenox-mancozeb zineb article carbohydrate analysis chemistry crystallization desorption drug combination ionization mass spectrometry methodology protein analysis protein structure ultraviolet radiation ultraviolet spectrophotometry Carbohydrates Crystallization Drug Combinations Gentisates Harmine Hydroxybenzoic Acids Indoles Maneb Polymers Proteins Pyridines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Zineb
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09514198_v15_n23_p2354_Nonami http://hdl.handle.net/20.500.12110/paper_09514198_v15_n23_p2354_Nonami
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09514198_v15_n23_p2354_Nonami
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spelling	paper:paper_09514198_v15_n23_p2354_Nonami2023-06-08T15:54:57Z Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Erra Balsells, Rosa 2,5-dihydroxybenzoic acid bipyridine derivative carbohydrate carboline derivative cyclodextrin gentisic acid harman harmine hydrogen hydroxybenzoic acid derivative indole derivative maneb nitrogen polymer protein pyridine derivative pyrifenox mancozeb pyrifenox-mancozeb zineb article carbohydrate analysis chemistry crystallization desorption drug combination ionization mass spectrometry methodology protein analysis protein structure ultraviolet radiation ultraviolet spectrophotometry Carbohydrates Crystallization Drug Combinations Gentisates Harmine Hydroxybenzoic Acids Indoles Maneb Polymers Proteins Pyridines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Zineb In an effort to gain an understanding of the processes governing ultraviolet matrix-assisted laser desorption/ionization (UV-MALDI), direct comparison was made of the mass spectra of proteins, carbohydrates and synthetic polymers (polyethylene glycol, polyester and polyamide) by using pyridylindoles, pyridoindoles and pyridylpyridoindoles as UV (337 nm)-MALDI-TOFMS matrices in positive and negative ion mode. In order to study the combined effect of the indole N-H and the pyridine nitrogen of the MALDI matrix on the desorption/ionization process in MALDI, compounds were selected that include either or both of these functions in their structure. Within the compounds studied only those that possess simultaneously both functions in a 1,4-relation behave as very good matrices for proteins. These compounds also work as matrices for some carbohydrates and synthetic polymers used as analytes in the present study. Some of the compounds were also found to be useful for the post-source decay (PSD) analysis of cyclodextrins in positive and negative ion mode. In several cases we also examined the matrix behavior of the corresponding N-methylindole derivatives. Copyright © 2001 John Wiley & Sons, Ltd. Fil:Erra-Balsells, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09514198_v15_n23_p2354_Nonami http://hdl.handle.net/20.500.12110/paper_09514198_v15_n23_p2354_Nonami
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	2,5-dihydroxybenzoic acid bipyridine derivative carbohydrate carboline derivative cyclodextrin gentisic acid harman harmine hydrogen hydroxybenzoic acid derivative indole derivative maneb nitrogen polymer protein pyridine derivative pyrifenox mancozeb pyrifenox-mancozeb zineb article carbohydrate analysis chemistry crystallization desorption drug combination ionization mass spectrometry methodology protein analysis protein structure ultraviolet radiation ultraviolet spectrophotometry Carbohydrates Crystallization Drug Combinations Gentisates Harmine Hydroxybenzoic Acids Indoles Maneb Polymers Proteins Pyridines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Zineb
spellingShingle	2,5-dihydroxybenzoic acid bipyridine derivative carbohydrate carboline derivative cyclodextrin gentisic acid harman harmine hydrogen hydroxybenzoic acid derivative indole derivative maneb nitrogen polymer protein pyridine derivative pyrifenox mancozeb pyrifenox-mancozeb zineb article carbohydrate analysis chemistry crystallization desorption drug combination ionization mass spectrometry methodology protein analysis protein structure ultraviolet radiation ultraviolet spectrophotometry Carbohydrates Crystallization Drug Combinations Gentisates Harmine Hydroxybenzoic Acids Indoles Maneb Polymers Proteins Pyridines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Zineb Erra Balsells, Rosa Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
topic_facet	2,5-dihydroxybenzoic acid bipyridine derivative carbohydrate carboline derivative cyclodextrin gentisic acid harman harmine hydrogen hydroxybenzoic acid derivative indole derivative maneb nitrogen polymer protein pyridine derivative pyrifenox mancozeb pyrifenox-mancozeb zineb article carbohydrate analysis chemistry crystallization desorption drug combination ionization mass spectrometry methodology protein analysis protein structure ultraviolet radiation ultraviolet spectrophotometry Carbohydrates Crystallization Drug Combinations Gentisates Harmine Hydroxybenzoic Acids Indoles Maneb Polymers Proteins Pyridines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Zineb
description	In an effort to gain an understanding of the processes governing ultraviolet matrix-assisted laser desorption/ionization (UV-MALDI), direct comparison was made of the mass spectra of proteins, carbohydrates and synthetic polymers (polyethylene glycol, polyester and polyamide) by using pyridylindoles, pyridoindoles and pyridylpyridoindoles as UV (337 nm)-MALDI-TOFMS matrices in positive and negative ion mode. In order to study the combined effect of the indole N-H and the pyridine nitrogen of the MALDI matrix on the desorption/ionization process in MALDI, compounds were selected that include either or both of these functions in their structure. Within the compounds studied only those that possess simultaneously both functions in a 1,4-relation behave as very good matrices for proteins. These compounds also work as matrices for some carbohydrates and synthetic polymers used as analytes in the present study. Some of the compounds were also found to be useful for the post-source decay (PSD) analysis of cyclodextrins in positive and negative ion mode. In several cases we also examined the matrix behavior of the corresponding N-methylindole derivatives. Copyright © 2001 John Wiley & Sons, Ltd.
author	Erra Balsells, Rosa
author_facet	Erra Balsells, Rosa
author_sort	Erra Balsells, Rosa
title	Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
title_short	Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
title_full	Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
title_fullStr	Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
title_full_unstemmed	Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
title_sort	evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
publishDate	2001
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09514198_v15_n23_p2354_Nonami http://hdl.handle.net/20.500.12110/paper_09514198_v15_n23_p2354_Nonami
work_keys_str_mv	AT errabalsellsrosa evaluationofpyridoindolespyridylindolesandpyridylpyridoindolesasmatricesforultravioletmatrixassistedlaserdesorptionionizationtimeofflightmassspectrometry
_version_	1768546500453859328

Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

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