Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis
Treatment of human immunodeficiency virus type 1 (HIV-1, causative agent of AIDS) infection represents a major challenge in antiviral therapeutics. Many difficulties are associated with the treatment, including toxicity, resistance and high costs. Taking this into account, research for novel compoun...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n5_p707_Trinchero http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n5_p707_Trinchero |
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paper:paper_0951418X_v23_n5_p707_Trinchero2023-06-08T15:54:56Z Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis Antiviral activity Brown seaweeds Fucoidans HIV fucoidin galactofucan unclassified drug zidovudine anti human immunodeficiency virus agent fucoidin plant extract polysaccharide adenocystis utricularis antiviral activity article cell culture cell wall controlled study Herpes simplex virus human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection in vitro study nonhuman peripheral blood mononuclear cell seaweed virus particle virus replication virus resistance brown alga cell line chemistry drug effect Human immunodeficiency virus 1 physiology seaweed Adenocystis utricularis Human immunodeficiency virus 1 Simplexvirus Algae, Brown Anti-HIV Agents Cell Line Cell Wall HIV-1 Humans Plant Extracts Polysaccharides Seaweed Virus Replication Treatment of human immunodeficiency virus type 1 (HIV-1, causative agent of AIDS) infection represents a major challenge in antiviral therapeutics. Many difficulties are associated with the treatment, including toxicity, resistance and high costs. Taking this into account, research for novel compounds able to overcome these limitations is needed. Sulfated polysaccharides appear to be interesting, given their abundance as components of seaweeds. Herein, a series of fractions obtained from the brown seaweed Adenocystis utricularis was analysed for in vitro anti-HIV-1 activity. These fractions, which have anti-herpes simplex virus activity, were determined previously to belong to the family of fucoidans, sulfated polysaccharides obtained from the cell walls of brown seaweeds. Assays in human PBMC primary cell culture demonstrated that two of the five fractions analysed had potent anti-HIV-1 activity both against WT and drug-resistant HIV-1 strains. For active fractions, it was also shown that the inhibitory effect was not due to an inactivating effect on the viral particle (i.e. no virucidal activity was detected) but rather to a blockade of early events of viral replication. Given these encouraging results, these seaweed-derived fractions appear as good candidates for further studies on their potential for in vivo therapy and/or prophylaxis of HIV-1 infection. Copyright © 2008 John Wiley & Sons, Ltd. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n5_p707_Trinchero http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n5_p707_Trinchero |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral activity Brown seaweeds Fucoidans HIV fucoidin galactofucan unclassified drug zidovudine anti human immunodeficiency virus agent fucoidin plant extract polysaccharide adenocystis utricularis antiviral activity article cell culture cell wall controlled study Herpes simplex virus human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection in vitro study nonhuman peripheral blood mononuclear cell seaweed virus particle virus replication virus resistance brown alga cell line chemistry drug effect Human immunodeficiency virus 1 physiology seaweed Adenocystis utricularis Human immunodeficiency virus 1 Simplexvirus Algae, Brown Anti-HIV Agents Cell Line Cell Wall HIV-1 Humans Plant Extracts Polysaccharides Seaweed Virus Replication |
| spellingShingle |
Antiviral activity Brown seaweeds Fucoidans HIV fucoidin galactofucan unclassified drug zidovudine anti human immunodeficiency virus agent fucoidin plant extract polysaccharide adenocystis utricularis antiviral activity article cell culture cell wall controlled study Herpes simplex virus human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection in vitro study nonhuman peripheral blood mononuclear cell seaweed virus particle virus replication virus resistance brown alga cell line chemistry drug effect Human immunodeficiency virus 1 physiology seaweed Adenocystis utricularis Human immunodeficiency virus 1 Simplexvirus Algae, Brown Anti-HIV Agents Cell Line Cell Wall HIV-1 Humans Plant Extracts Polysaccharides Seaweed Virus Replication Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| topic_facet |
Antiviral activity Brown seaweeds Fucoidans HIV fucoidin galactofucan unclassified drug zidovudine anti human immunodeficiency virus agent fucoidin plant extract polysaccharide adenocystis utricularis antiviral activity article cell culture cell wall controlled study Herpes simplex virus human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection in vitro study nonhuman peripheral blood mononuclear cell seaweed virus particle virus replication virus resistance brown alga cell line chemistry drug effect Human immunodeficiency virus 1 physiology seaweed Adenocystis utricularis Human immunodeficiency virus 1 Simplexvirus Algae, Brown Anti-HIV Agents Cell Line Cell Wall HIV-1 Humans Plant Extracts Polysaccharides Seaweed Virus Replication |
| description |
Treatment of human immunodeficiency virus type 1 (HIV-1, causative agent of AIDS) infection represents a major challenge in antiviral therapeutics. Many difficulties are associated with the treatment, including toxicity, resistance and high costs. Taking this into account, research for novel compounds able to overcome these limitations is needed. Sulfated polysaccharides appear to be interesting, given their abundance as components of seaweeds. Herein, a series of fractions obtained from the brown seaweed Adenocystis utricularis was analysed for in vitro anti-HIV-1 activity. These fractions, which have anti-herpes simplex virus activity, were determined previously to belong to the family of fucoidans, sulfated polysaccharides obtained from the cell walls of brown seaweeds. Assays in human PBMC primary cell culture demonstrated that two of the five fractions analysed had potent anti-HIV-1 activity both against WT and drug-resistant HIV-1 strains. For active fractions, it was also shown that the inhibitory effect was not due to an inactivating effect on the viral particle (i.e. no virucidal activity was detected) but rather to a blockade of early events of viral replication. Given these encouraging results, these seaweed-derived fractions appear as good candidates for further studies on their potential for in vivo therapy and/or prophylaxis of HIV-1 infection. Copyright © 2008 John Wiley & Sons, Ltd. |
| title |
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| title_short |
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| title_full |
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| title_fullStr |
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| title_full_unstemmed |
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis |
| title_sort |
antiretroviral activity of fucoidans extracted from the brown seaweed adenocystis utricularis |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n5_p707_Trinchero http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n5_p707_Trinchero |
| _version_ |
1768544092963209216 |