In vitro and in vivo activity of eugenol on human herpesvirus

Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25...

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Autor principal:	Benencia, Fabián
Publicado:	2000
Materias:	Acyclovir Antiviral activity Eugenol Herpesvirus Herpetic keratitis aciclovir eugenol animal cell animal experiment animal model antiviral activity article controlled study cytotoxicity drug mixture drug potentiation herpes simplex keratitis Herpes simplex virus 1 Herpes simplex virus 2 Herpes virus infection IC 50 mouse nonhuman phytotherapy Vero cell virus replication Animals Antiviral Agents Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Herpes Simplex Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Vero Cells Animalia Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v14_n7_p495_Benencia http://hdl.handle.net/20.500.12110/paper_0951418X_v14_n7_p495_Benencia
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0951418X_v14_n7_p495_Benencia
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spelling	paper:paper_0951418X_v14_n7_p495_Benencia2023-06-08T15:54:54Z In vitro and in vivo activity of eugenol on human herpesvirus Benencia, Fabián Acyclovir Antiviral activity Eugenol Herpesvirus Herpetic keratitis aciclovir eugenol animal cell animal experiment animal model antiviral activity article controlled study cytotoxicity drug mixture drug potentiation herpes simplex keratitis Herpes simplex virus 1 Herpes simplex virus 2 Herpes virus infection IC 50 mouse nonhuman phytotherapy Vero cell virus replication Acyclovir Animals Antiviral Agents Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Eugenol Herpes Simplex Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Vero Cells Animalia Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 μg/mL and 16.2 μg/mL for HSV-1 and HSV-2 respectively, 250 μg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. (C) 2000 John Wiley and Sons, Ltd. Fil:Benencia, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v14_n7_p495_Benencia http://hdl.handle.net/20.500.12110/paper_0951418X_v14_n7_p495_Benencia
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acyclovir Antiviral activity Eugenol Herpesvirus Herpetic keratitis aciclovir eugenol animal cell animal experiment animal model antiviral activity article controlled study cytotoxicity drug mixture drug potentiation herpes simplex keratitis Herpes simplex virus 1 Herpes simplex virus 2 Herpes virus infection IC 50 mouse nonhuman phytotherapy Vero cell virus replication Acyclovir Animals Antiviral Agents Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Eugenol Herpes Simplex Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Vero Cells Animalia Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2
spellingShingle	Acyclovir Antiviral activity Eugenol Herpesvirus Herpetic keratitis aciclovir eugenol animal cell animal experiment animal model antiviral activity article controlled study cytotoxicity drug mixture drug potentiation herpes simplex keratitis Herpes simplex virus 1 Herpes simplex virus 2 Herpes virus infection IC 50 mouse nonhuman phytotherapy Vero cell virus replication Acyclovir Animals Antiviral Agents Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Eugenol Herpes Simplex Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Vero Cells Animalia Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Benencia, Fabián In vitro and in vivo activity of eugenol on human herpesvirus
topic_facet	Acyclovir Antiviral activity Eugenol Herpesvirus Herpetic keratitis aciclovir eugenol animal cell animal experiment animal model antiviral activity article controlled study cytotoxicity drug mixture drug potentiation herpes simplex keratitis Herpes simplex virus 1 Herpes simplex virus 2 Herpes virus infection IC 50 mouse nonhuman phytotherapy Vero cell virus replication Acyclovir Animals Antiviral Agents Cercopithecus aethiops Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Eugenol Herpes Simplex Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Vero Cells Animalia Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2
description	Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 μg/mL and 16.2 μg/mL for HSV-1 and HSV-2 respectively, 250 μg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. (C) 2000 John Wiley and Sons, Ltd.
author	Benencia, Fabián
author_facet	Benencia, Fabián
author_sort	Benencia, Fabián
title	In vitro and in vivo activity of eugenol on human herpesvirus
title_short	In vitro and in vivo activity of eugenol on human herpesvirus
title_full	In vitro and in vivo activity of eugenol on human herpesvirus
title_fullStr	In vitro and in vivo activity of eugenol on human herpesvirus
title_full_unstemmed	In vitro and in vivo activity of eugenol on human herpesvirus
title_sort	in vitro and in vivo activity of eugenol on human herpesvirus
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v14_n7_p495_Benencia http://hdl.handle.net/20.500.12110/paper_0951418X_v14_n7_p495_Benencia
work_keys_str_mv	AT benenciafabian invitroandinvivoactivityofeugenolonhumanherpesvirus
_version_	1768545935951921152

In vitro and in vivo activity of eugenol on human herpesvirus

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