The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies

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Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothy...

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Autor principal:	Barreiro Arcos, María Laura
Publicado:	2016
Materias:	Antitumor immune response Apoptosis Proliferation T cell lymphoma Thyroid hormones CD9 antigen gamma interferon propylthiouracil thyroid hormone animal cell animal experiment apoptosis Article B lymphocyte cancer growth CD8+ T lymphocyte cell cycle cell proliferation controlled study cytotoxic T lymphocyte cytotoxicity euthyroidism female hyperthyroidism hypothyroidism immune response immunocompetent cell lymphocyte function mouse natural killer cell nonhuman spleen suppressor cell T lymphocyte T lymphocyte subpopulation T-Cell lymphoma cell line tumor cell inoculation tumor microenvironment animal cell line complication disease model drug effects immunology immunomodulation lymphocyte count metabolism metastasis pathology thyroid disease tumor volume Animals Cell Line Cell Proliferation Disease Models, Animal Female Hyperthyroidism Hypothyroidism Immunomodulation Lymphocyte Count Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocyte Subsets Thyroid Diseases Thyroid Hormones Tumor Burden Tumor Microenvironment
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09462716_v94_n4_p417_Sterle http://hdl.handle.net/20.500.12110/paper_09462716_v94_n4_p417_Sterle
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_09462716_v94_n4_p417_Sterle2023-06-08T15:53:53Z The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies Barreiro Arcos, María Laura Antitumor immune response Apoptosis Proliferation T cell lymphoma Thyroid hormones CD9 antigen gamma interferon propylthiouracil thyroid hormone thyroid hormone animal cell animal experiment apoptosis Article B lymphocyte cancer growth CD8+ T lymphocyte cell cycle cell proliferation controlled study cytotoxic T lymphocyte cytotoxicity euthyroidism female hyperthyroidism hypothyroidism immune response immunocompetent cell lymphocyte function mouse natural killer cell nonhuman spleen suppressor cell T cell lymphoma T lymphocyte T lymphocyte subpopulation T-Cell lymphoma cell line tumor cell inoculation tumor microenvironment animal cell line complication disease model drug effects hyperthyroidism hypothyroidism immunology immunomodulation lymphocyte count metabolism metastasis pathology T cell lymphoma thyroid disease tumor volume Animals Apoptosis Cell Line Cell Proliferation Disease Models, Animal Female Hyperthyroidism Hypothyroidism Immunomodulation Lymphocyte Count Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocyte Subsets Thyroid Diseases Thyroid Hormones Tumor Burden Tumor Microenvironment Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothyroid) that developed solid tumors or metastases after inoculation of syngeneic T lymphoma cells. Hyperthyroid mice showed increased tumor growth along with increased expression of cell cycle regulators compared to hypothyroid and control tumor-bearing mice. However, hypothyroid mice showed a higher frequency of metastases than the other groups. Hyperthyroid mice bearing tumors displayed a lower number of tumor-infiltrating T lymphocytes, lower percentage of functional IFN-γ-producing CD8+ T cells, and higher percentage of CD19+ B cells than euthyroid tumor-bearing mice. However, no differences were found in the distribution of lymphocyte subpopulations in tumor-draining lymph nodes (TDLNs) or spleens among different experimental groups. Interestingly, hypothyroid TDLN showed an increased percentage of regulatory T (Treg) cells, while hyperthyroid mice displayed increased number and activity of splenic NK cells, which frequency declined in spleens from hypothyroid mice. Moreover, a decreased number of splenic myeloid-derived suppressor cells (MDSCs) were found in tumor-bearing hyperthyroid mice as compared to hypothyroid or euthyroid mice. Additionally, hyperthyroid mice showed increased cytotoxic activity, which declined in hypothyroid mice. Thus, low levels of intratumoral cytotoxic activity would favor tumor local growth in hyperthyroid mice, while regional and systemic antitumor response may contribute to tumor dissemination in hypothyroid animals. Our results highlight the importance of monitoring the thyroid status in patients with T cell lymphomas. Key messages: T cell lymphoma phenotype is paradoxically influenced by thyroid status.Hyperthyroidism favors tumor growth and hypothyroidism rises tumor dissemination.Thyroid status affects the distribution of immune cell types in the tumor milieu.Thyroid status also modifies the nature of local and systemic immune responses. © 2015, Springer-Verlag Berlin Heidelberg. Fil:Barreiro Arcos, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09462716_v94_n4_p417_Sterle http://hdl.handle.net/20.500.12110/paper_09462716_v94_n4_p417_Sterle
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antitumor immune response Apoptosis Proliferation T cell lymphoma Thyroid hormones CD9 antigen gamma interferon propylthiouracil thyroid hormone thyroid hormone animal cell animal experiment apoptosis Article B lymphocyte cancer growth CD8+ T lymphocyte cell cycle cell proliferation controlled study cytotoxic T lymphocyte cytotoxicity euthyroidism female hyperthyroidism hypothyroidism immune response immunocompetent cell lymphocyte function mouse natural killer cell nonhuman spleen suppressor cell T cell lymphoma T lymphocyte T lymphocyte subpopulation T-Cell lymphoma cell line tumor cell inoculation tumor microenvironment animal cell line complication disease model drug effects hyperthyroidism hypothyroidism immunology immunomodulation lymphocyte count metabolism metastasis pathology T cell lymphoma thyroid disease tumor volume Animals Apoptosis Cell Line Cell Proliferation Disease Models, Animal Female Hyperthyroidism Hypothyroidism Immunomodulation Lymphocyte Count Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocyte Subsets Thyroid Diseases Thyroid Hormones Tumor Burden Tumor Microenvironment
spellingShingle	Antitumor immune response Apoptosis Proliferation T cell lymphoma Thyroid hormones CD9 antigen gamma interferon propylthiouracil thyroid hormone thyroid hormone animal cell animal experiment apoptosis Article B lymphocyte cancer growth CD8+ T lymphocyte cell cycle cell proliferation controlled study cytotoxic T lymphocyte cytotoxicity euthyroidism female hyperthyroidism hypothyroidism immune response immunocompetent cell lymphocyte function mouse natural killer cell nonhuman spleen suppressor cell T cell lymphoma T lymphocyte T lymphocyte subpopulation T-Cell lymphoma cell line tumor cell inoculation tumor microenvironment animal cell line complication disease model drug effects hyperthyroidism hypothyroidism immunology immunomodulation lymphocyte count metabolism metastasis pathology T cell lymphoma thyroid disease tumor volume Animals Apoptosis Cell Line Cell Proliferation Disease Models, Animal Female Hyperthyroidism Hypothyroidism Immunomodulation Lymphocyte Count Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocyte Subsets Thyroid Diseases Thyroid Hormones Tumor Burden Tumor Microenvironment Barreiro Arcos, María Laura The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
topic_facet	Antitumor immune response Apoptosis Proliferation T cell lymphoma Thyroid hormones CD9 antigen gamma interferon propylthiouracil thyroid hormone thyroid hormone animal cell animal experiment apoptosis Article B lymphocyte cancer growth CD8+ T lymphocyte cell cycle cell proliferation controlled study cytotoxic T lymphocyte cytotoxicity euthyroidism female hyperthyroidism hypothyroidism immune response immunocompetent cell lymphocyte function mouse natural killer cell nonhuman spleen suppressor cell T cell lymphoma T lymphocyte T lymphocyte subpopulation T-Cell lymphoma cell line tumor cell inoculation tumor microenvironment animal cell line complication disease model drug effects hyperthyroidism hypothyroidism immunology immunomodulation lymphocyte count metabolism metastasis pathology T cell lymphoma thyroid disease tumor volume Animals Apoptosis Cell Line Cell Proliferation Disease Models, Animal Female Hyperthyroidism Hypothyroidism Immunomodulation Lymphocyte Count Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocyte Subsets Thyroid Diseases Thyroid Hormones Tumor Burden Tumor Microenvironment
description	Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothyroid) that developed solid tumors or metastases after inoculation of syngeneic T lymphoma cells. Hyperthyroid mice showed increased tumor growth along with increased expression of cell cycle regulators compared to hypothyroid and control tumor-bearing mice. However, hypothyroid mice showed a higher frequency of metastases than the other groups. Hyperthyroid mice bearing tumors displayed a lower number of tumor-infiltrating T lymphocytes, lower percentage of functional IFN-γ-producing CD8+ T cells, and higher percentage of CD19+ B cells than euthyroid tumor-bearing mice. However, no differences were found in the distribution of lymphocyte subpopulations in tumor-draining lymph nodes (TDLNs) or spleens among different experimental groups. Interestingly, hypothyroid TDLN showed an increased percentage of regulatory T (Treg) cells, while hyperthyroid mice displayed increased number and activity of splenic NK cells, which frequency declined in spleens from hypothyroid mice. Moreover, a decreased number of splenic myeloid-derived suppressor cells (MDSCs) were found in tumor-bearing hyperthyroid mice as compared to hypothyroid or euthyroid mice. Additionally, hyperthyroid mice showed increased cytotoxic activity, which declined in hypothyroid mice. Thus, low levels of intratumoral cytotoxic activity would favor tumor local growth in hyperthyroid mice, while regional and systemic antitumor response may contribute to tumor dissemination in hypothyroid animals. Our results highlight the importance of monitoring the thyroid status in patients with T cell lymphomas. Key messages: T cell lymphoma phenotype is paradoxically influenced by thyroid status.Hyperthyroidism favors tumor growth and hypothyroidism rises tumor dissemination.Thyroid status affects the distribution of immune cell types in the tumor milieu.Thyroid status also modifies the nature of local and systemic immune responses. © 2015, Springer-Verlag Berlin Heidelberg.
author	Barreiro Arcos, María Laura
author_facet	Barreiro Arcos, María Laura
author_sort	Barreiro Arcos, María Laura
title	The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_short	The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_full	The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_fullStr	The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_full_unstemmed	The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_sort	thyroid status reprograms t cell lymphoma growth and modulates immune cell frequencies
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09462716_v94_n4_p417_Sterle http://hdl.handle.net/20.500.12110/paper_09462716_v94_n4_p417_Sterle
work_keys_str_mv	AT barreiroarcosmarialaura thethyroidstatusreprogramstcelllymphomagrowthandmodulatesimmunecellfrequencies AT barreiroarcosmarialaura thyroidstatusreprogramstcelllymphomagrowthandmodulatesimmunecellfrequencies
_version_	1768545655501881344

The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies

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