Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis

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Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regenerat...

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Autores principales:	Jungblut, Lucas David, Paz, Dante Agustin
Publicado:	2007
Materias:	Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor zinc sulfate animal tissue Article controlled study embryo glia cell granular cell larva neural stem cell nonhuman olfactory bulb olfactory epithelium olfactory nerve protein analysis protein expression protein function tissue regeneration Xenopus laevis animal metabolism nerve regeneration nervous system development pathology pathophysiology physiology Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Olfactory Bulb Olfactory Mucosa
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09409602_v198_n_p41_Frontera http://hdl.handle.net/20.500.12110/paper_09409602_v198_n_p41_Frontera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09409602_v198_n_p41_Frontera
record_format	dspace
spelling	paper:paper_09409602_v198_n_p41_Frontera2023-06-08T15:53:33Z Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis Jungblut, Lucas David Paz, Dante Agustin Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor zinc sulfate brain derived neurotrophic factor animal tissue Article controlled study embryo glia cell granular cell larva neural stem cell nonhuman olfactory bulb olfactory epithelium olfactory nerve protein analysis protein expression protein function tissue regeneration Xenopus laevis animal metabolism nerve regeneration nervous system development olfactory epithelium pathology pathophysiology physiology Xenopus laevis Xenopus laevis Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Neurogenesis Olfactory Bulb Olfactory Mucosa Xenopus laevis Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system. © 2014 Elsevier GmbH. Fil:Jungblut, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paz, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09409602_v198_n_p41_Frontera http://hdl.handle.net/20.500.12110/paper_09409602_v198_n_p41_Frontera
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor zinc sulfate brain derived neurotrophic factor animal tissue Article controlled study embryo glia cell granular cell larva neural stem cell nonhuman olfactory bulb olfactory epithelium olfactory nerve protein analysis protein expression protein function tissue regeneration Xenopus laevis animal metabolism nerve regeneration nervous system development olfactory epithelium pathology pathophysiology physiology Xenopus laevis Xenopus laevis Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Neurogenesis Olfactory Bulb Olfactory Mucosa Xenopus laevis
spellingShingle	Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor zinc sulfate brain derived neurotrophic factor animal tissue Article controlled study embryo glia cell granular cell larva neural stem cell nonhuman olfactory bulb olfactory epithelium olfactory nerve protein analysis protein expression protein function tissue regeneration Xenopus laevis animal metabolism nerve regeneration nervous system development olfactory epithelium pathology pathophysiology physiology Xenopus laevis Xenopus laevis Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Neurogenesis Olfactory Bulb Olfactory Mucosa Xenopus laevis Jungblut, Lucas David Paz, Dante Agustin Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
topic_facet	Neural stem cells Neurogenesis Neurotrophins Olfactory bulb Olfactory neurons Sustentacular cells brain derived neurotrophic factor zinc sulfate brain derived neurotrophic factor animal tissue Article controlled study embryo glia cell granular cell larva neural stem cell nonhuman olfactory bulb olfactory epithelium olfactory nerve protein analysis protein expression protein function tissue regeneration Xenopus laevis animal metabolism nerve regeneration nervous system development olfactory epithelium pathology pathophysiology physiology Xenopus laevis Xenopus laevis Animals Brain-Derived Neurotrophic Factor Nerve Regeneration Neurogenesis Olfactory Bulb Olfactory Mucosa Xenopus laevis
description	Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system. © 2014 Elsevier GmbH.
author	Jungblut, Lucas David Paz, Dante Agustin
author_facet	Jungblut, Lucas David Paz, Dante Agustin
author_sort	Jungblut, Lucas David
title	Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_short	Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_full	Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_fullStr	Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_full_unstemmed	Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
title_sort	brain-derived neurotrophic factor (bdnf) expression in normal and regenerating olfactory epithelium of xenopus laevis
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09409602_v198_n_p41_Frontera http://hdl.handle.net/20.500.12110/paper_09409602_v198_n_p41_Frontera
work_keys_str_mv	AT jungblutlucasdavid brainderivedneurotrophicfactorbdnfexpressioninnormalandregeneratingolfactoryepitheliumofxenopuslaevis AT pazdanteagustin brainderivedneurotrophicfactorbdnfexpressioninnormalandregeneratingolfactoryepitheliumofxenopuslaevis
_version_	1768546452307443712

Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis

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