Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A

Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative...

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Autores principales: Monteagudo, Edith Sandra, Veleiro, Adriana Silvia, Burton, Gerardo, Gros, Eduardo Gervasio
Publicado: 1987
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09320776_v42_n11_p1471_Monteagudo
http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_09320776_v42_n11_p1471_Monteagudo
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spelling paper:paper_09320776_v42_n11_p1471_Monteagudo2023-06-08T15:53:04Z Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A Monteagudo, Edith Sandra Veleiro, Adriana Silvia Burton, Gerardo Gros, Eduardo Gervasio Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative specific activity of these carbon atoms was consistent with our previous results indicating the partial cleavage of the side chain of a sterol precursor in the biosynthetic process leading to the withanolides. © 1987, Walter de Gruyter. All rights reserved. Fil:Monteagudo, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09320776_v42_n11_p1471_Monteagudo http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Administration of [2-14C]mevalonolactone to excised leaves of Acnistus breviflorus produced labelled withaferin A and jaborosalactone A. Degradation of the labelled withanolides allowed isolation of C-26. and in the case of withaferin A of C-1, both derived from C-2 of mevalonolactone. The relative specific activity of these carbon atoms was consistent with our previous results indicating the partial cleavage of the side chain of a sterol precursor in the biosynthetic process leading to the withanolides. © 1987, Walter de Gruyter. All rights reserved.
author Monteagudo, Edith Sandra
Veleiro, Adriana Silvia
Burton, Gerardo
Gros, Eduardo Gervasio
spellingShingle Monteagudo, Edith Sandra
Veleiro, Adriana Silvia
Burton, Gerardo
Gros, Eduardo Gervasio
Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
author_facet Monteagudo, Edith Sandra
Veleiro, Adriana Silvia
Burton, Gerardo
Gros, Eduardo Gervasio
author_sort Monteagudo, Edith Sandra
title Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_short Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_full Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_fullStr Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_full_unstemmed Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A
title_sort biosynthesis of withanolides in acnistus breviflorus chemical degradation of 14c-labelled jaborosalactone a and withaferin a
publishDate 1987
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09320776_v42_n11_p1471_Monteagudo
http://hdl.handle.net/20.500.12110/paper_09320776_v42_n11_p1471_Monteagudo
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AT veleiroadrianasilvia biosynthesisofwithanolidesinacnistusbrevifloruschemicaldegradationof14clabelledjaborosalactoneaandwithaferina
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