Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome

Renal disease is the most important long-term complication of hemolytic-uremic syndrome (HUS). A comparative study of renal function was carried out in two groups of patients. Group 1 included 19 children followed for a median of 11 years, 1960-1980, with a low-sodium diet, antihypertensive drugs, a...

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Publicado:	2004
Materias:	Angiotensin converting enzyme inhibitors Chronic renal failure Hemolytic-uremic syndrome Historical study Protein intake antihypertensive agent creatinine dipeptidyl carboxypeptidase inhibitor enalapril furosemide prazosin article chronic kidney failure clinical article controlled study correlation coefficient creatinine blood level female Fisher exact test follow up hemolytic uremic syndrome human hypertension kidney function linear regression analysis longitudinal study male priority journal protein intake protein restriction proteinuria sodium restriction statistical significance Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Child Child, Preschool Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Female Hemolytic-Uremic Syndrome Humans Infant Kidney Failure, Chronic Male Time Factors Treatment Outcome
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0931041X_v19_n10_p1148_Caletti http://hdl.handle.net/20.500.12110/paper_0931041X_v19_n10_p1148_Caletti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0931041X_v19_n10_p1148_Caletti
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spelling	paper:paper_0931041X_v19_n10_p1148_Caletti2023-06-08T15:52:53Z Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome Angiotensin converting enzyme inhibitors Chronic renal failure Hemolytic-uremic syndrome Historical study Protein intake antihypertensive agent creatinine dipeptidyl carboxypeptidase inhibitor enalapril furosemide prazosin article chronic kidney failure clinical article controlled study correlation coefficient creatinine blood level female Fisher exact test follow up hemolytic uremic syndrome human hypertension kidney function linear regression analysis longitudinal study male priority journal protein intake protein restriction proteinuria sodium restriction statistical significance Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Child Child, Preschool Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Female Hemolytic-Uremic Syndrome Humans Infant Kidney Failure, Chronic Male Time Factors Treatment Outcome Renal disease is the most important long-term complication of hemolytic-uremic syndrome (HUS). A comparative study of renal function was carried out in two groups of patients. Group 1 included 19 children followed for a median of 11 years, 1960-1980, with a low-sodium diet, antihypertensive drugs, and a restricted protein intake in the end stage of renal disease. Group 2 included 26 children treated for a median of 9 years, 1988-2002, on a low-sodium diet, early restriction of protein intake according to recommendations, and angiotensin converting enzyme inhibitors (ACEi). Long-term renal function was assessed by the inverse of the plasma creatinine concentration (1/[Cr]) over time. Linear regression lines were fitted to individual values of 1/[Cr] for each child. Regression coefficients of children in group 1 were all negative, ranging from -0.031 to -0.00043; 7 were significantly different from zero, indicating a linear fall in renal function over time. In contrast, children from group 2 had 11 negative slopes (only 1 significant) and 15 positive slopes, ranging from 0.17893 to -0.3899. Fisher's exact test showed that group 1 had significantly more children with negative slopes than group 2. This comparatively better long-term outcome of renal function in children under contemporary treatment was probably associated with early restriction of protein and use of ACEi. © IPNA 2004. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0931041X_v19_n10_p1148_Caletti http://hdl.handle.net/20.500.12110/paper_0931041X_v19_n10_p1148_Caletti
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiotensin converting enzyme inhibitors Chronic renal failure Hemolytic-uremic syndrome Historical study Protein intake antihypertensive agent creatinine dipeptidyl carboxypeptidase inhibitor enalapril furosemide prazosin article chronic kidney failure clinical article controlled study correlation coefficient creatinine blood level female Fisher exact test follow up hemolytic uremic syndrome human hypertension kidney function linear regression analysis longitudinal study male priority journal protein intake protein restriction proteinuria sodium restriction statistical significance Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Child Child, Preschool Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Female Hemolytic-Uremic Syndrome Humans Infant Kidney Failure, Chronic Male Time Factors Treatment Outcome
spellingShingle	Angiotensin converting enzyme inhibitors Chronic renal failure Hemolytic-uremic syndrome Historical study Protein intake antihypertensive agent creatinine dipeptidyl carboxypeptidase inhibitor enalapril furosemide prazosin article chronic kidney failure clinical article controlled study correlation coefficient creatinine blood level female Fisher exact test follow up hemolytic uremic syndrome human hypertension kidney function linear regression analysis longitudinal study male priority journal protein intake protein restriction proteinuria sodium restriction statistical significance Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Child Child, Preschool Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Female Hemolytic-Uremic Syndrome Humans Infant Kidney Failure, Chronic Male Time Factors Treatment Outcome Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
topic_facet	Angiotensin converting enzyme inhibitors Chronic renal failure Hemolytic-uremic syndrome Historical study Protein intake antihypertensive agent creatinine dipeptidyl carboxypeptidase inhibitor enalapril furosemide prazosin article chronic kidney failure clinical article controlled study correlation coefficient creatinine blood level female Fisher exact test follow up hemolytic uremic syndrome human hypertension kidney function linear regression analysis longitudinal study male priority journal protein intake protein restriction proteinuria sodium restriction statistical significance Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Child Child, Preschool Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Female Hemolytic-Uremic Syndrome Humans Infant Kidney Failure, Chronic Male Time Factors Treatment Outcome
description	Renal disease is the most important long-term complication of hemolytic-uremic syndrome (HUS). A comparative study of renal function was carried out in two groups of patients. Group 1 included 19 children followed for a median of 11 years, 1960-1980, with a low-sodium diet, antihypertensive drugs, and a restricted protein intake in the end stage of renal disease. Group 2 included 26 children treated for a median of 9 years, 1988-2002, on a low-sodium diet, early restriction of protein intake according to recommendations, and angiotensin converting enzyme inhibitors (ACEi). Long-term renal function was assessed by the inverse of the plasma creatinine concentration (1/[Cr]) over time. Linear regression lines were fitted to individual values of 1/[Cr] for each child. Regression coefficients of children in group 1 were all negative, ranging from -0.031 to -0.00043; 7 were significantly different from zero, indicating a linear fall in renal function over time. In contrast, children from group 2 had 11 negative slopes (only 1 significant) and 15 positive slopes, ranging from 0.17893 to -0.3899. Fisher's exact test showed that group 1 had significantly more children with negative slopes than group 2. This comparatively better long-term outcome of renal function in children under contemporary treatment was probably associated with early restriction of protein and use of ACEi. © IPNA 2004.
title	Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
title_short	Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
title_full	Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
title_fullStr	Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
title_full_unstemmed	Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
title_sort	two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0931041X_v19_n10_p1148_Caletti http://hdl.handle.net/20.500.12110/paper_0931041X_v19_n10_p1148_Caletti
_version_	1768546682892451840

Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome

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