Acridones as antiviral agents: Synthesis, chemical and biological properties
Acridones are a class of compounds that have attracted attention in recent years for their wide range of biological properties, including selective inhibition of diverse human pathogenic viruses. The wide spectrum of antiviral activity includes DNA and RNA viruses, such as herpes simplex virus, cyto...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v20_n19_p2402_Sepulveda http://hdl.handle.net/20.500.12110/paper_09298673_v20_n19_p2402_Sepulveda |
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paper:paper_09298673_v20_n19_p2402_Sepulveda2023-06-08T15:52:27Z Acridones as antiviral agents: Synthesis, chemical and biological properties Sepúlveda, Claudia Soledad Fascio, Mirta Liliana García, Cybele Carina D'Accorso, Norma Beatriz Damonte, Elsa Beatriz Acridones Antiviral activity Arenavirus Cellular target Flavivirus Herpes simplex virus 1 hydroxy 10 methyl 9(10h) acridone 1,3 dihydroxy 5 methoxyacridone 10 allyl 6 chloro 4 methoxy 9(10h) acridone 10 allyl 6 chloro 9(10h) acridone 2 fluoro 5 methoxy n (pyridine 3 yl)acridone 4 carboxamide 3 allyloxy 7 methoxy 1 hydroxyacridone 3,7 dimethoxy 1 hydroxyacridone 5 chloro 1,3 dihydroxyacridone 7 amino 1,3 dihydroxy 10 methyl 6 [4 (2 pyridinyl) 1 piperazinyl] 9(10h) acridone 7 amino 1,3 dimethoxy 10 methyl 6 [4 (4 thiazol) 1 piperazinyl] 9(10h) acridone 7 chloro 1,3 dihydroxyacridone 7 nitro 6 chloro 1,3 dimethoxy 10 methyl 9(10h) acridone aciclovir acridone derivative antivirus agent citrusinine 1 cridanimod cycloferon didanosine glycofolinine n (3 methyl 2 butenyl) 9(10h) acridone derivative n (pyridin 2 yl)acridone 4 carboxamide n (pyridin 4yl)acridone 4 carboxamide n cyclopropyl acridone 2 thioacetic acid n cyclopropyl acridone derivative nevirapine s deoxydihydroglyparvin temacrazine unclassified drug unindexed drug zidovudine antiviral activity article Bovine diarrhea virus chemical reaction cyclization cytotoxicity Dengue virus DNA virus drug mechanism drug structure drug synthesis drug targeting enzyme inhibition Hepatitis C virus Herpes simplex virus 1 Herpes simplex virus 2 Human adenovirus Human cytomegalovirus Human immunodeficiency virus 1 Junin virus Lymphocytic choriomeningitis virus nonhuman substitution reaction virus replication Acridones Animals Antiviral Agents DNA Virus Infections DNA Viruses Humans RNA Virus Infections RNA Viruses Acridones are a class of compounds that have attracted attention in recent years for their wide range of biological properties, including selective inhibition of diverse human pathogenic viruses. The wide spectrum of antiviral activity includes DNA and RNA viruses, such as herpes simplex virus, cytomegalovirus, adenovirus, hepatitis C virus, dengue virus, and Junin virus, among others, indicative of the involvement of cellular factors as potential targets of acridone derivatives. At the present, their precise mode of action is not clearly determined, although the predominant action seems to be centered on the synthesis of nucleic acids. Regarding this point, inhibitory activity against cellular and viral enzymes and the ability to intercalate into nucleic acid molecules was demonstrated for some acridone compounds. Then, the possibility of a multiple effect on different targets renewed interest in these agents for virus chemotherapy allowing a potent inhibitory effectiveness associated to less feasibility of generating antiviral resistance. This review summarizes the current knowledge regarding the methods of synthesis, the antiviral properties of acridone derivatives, their mechanism of action, and structural characteristics related to antiviral activity as well as the perspectives of this class of compounds for clinical application against human viral infections. © 2013 Bentham Science Publishers. Fil:Sepúlveda, C.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fascio, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v20_n19_p2402_Sepulveda http://hdl.handle.net/20.500.12110/paper_09298673_v20_n19_p2402_Sepulveda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acridones Antiviral activity Arenavirus Cellular target Flavivirus Herpes simplex virus 1 hydroxy 10 methyl 9(10h) acridone 1,3 dihydroxy 5 methoxyacridone 10 allyl 6 chloro 4 methoxy 9(10h) acridone 10 allyl 6 chloro 9(10h) acridone 2 fluoro 5 methoxy n (pyridine 3 yl)acridone 4 carboxamide 3 allyloxy 7 methoxy 1 hydroxyacridone 3,7 dimethoxy 1 hydroxyacridone 5 chloro 1,3 dihydroxyacridone 7 amino 1,3 dihydroxy 10 methyl 6 [4 (2 pyridinyl) 1 piperazinyl] 9(10h) acridone 7 amino 1,3 dimethoxy 10 methyl 6 [4 (4 thiazol) 1 piperazinyl] 9(10h) acridone 7 chloro 1,3 dihydroxyacridone 7 nitro 6 chloro 1,3 dimethoxy 10 methyl 9(10h) acridone aciclovir acridone derivative antivirus agent citrusinine 1 cridanimod cycloferon didanosine glycofolinine n (3 methyl 2 butenyl) 9(10h) acridone derivative n (pyridin 2 yl)acridone 4 carboxamide n (pyridin 4yl)acridone 4 carboxamide n cyclopropyl acridone 2 thioacetic acid n cyclopropyl acridone derivative nevirapine s deoxydihydroglyparvin temacrazine unclassified drug unindexed drug zidovudine antiviral activity article Bovine diarrhea virus chemical reaction cyclization cytotoxicity Dengue virus DNA virus drug mechanism drug structure drug synthesis drug targeting enzyme inhibition Hepatitis C virus Herpes simplex virus 1 Herpes simplex virus 2 Human adenovirus Human cytomegalovirus Human immunodeficiency virus 1 Junin virus Lymphocytic choriomeningitis virus nonhuman substitution reaction virus replication Acridones Animals Antiviral Agents DNA Virus Infections DNA Viruses Humans RNA Virus Infections RNA Viruses |
| spellingShingle |
Acridones Antiviral activity Arenavirus Cellular target Flavivirus Herpes simplex virus 1 hydroxy 10 methyl 9(10h) acridone 1,3 dihydroxy 5 methoxyacridone 10 allyl 6 chloro 4 methoxy 9(10h) acridone 10 allyl 6 chloro 9(10h) acridone 2 fluoro 5 methoxy n (pyridine 3 yl)acridone 4 carboxamide 3 allyloxy 7 methoxy 1 hydroxyacridone 3,7 dimethoxy 1 hydroxyacridone 5 chloro 1,3 dihydroxyacridone 7 amino 1,3 dihydroxy 10 methyl 6 [4 (2 pyridinyl) 1 piperazinyl] 9(10h) acridone 7 amino 1,3 dimethoxy 10 methyl 6 [4 (4 thiazol) 1 piperazinyl] 9(10h) acridone 7 chloro 1,3 dihydroxyacridone 7 nitro 6 chloro 1,3 dimethoxy 10 methyl 9(10h) acridone aciclovir acridone derivative antivirus agent citrusinine 1 cridanimod cycloferon didanosine glycofolinine n (3 methyl 2 butenyl) 9(10h) acridone derivative n (pyridin 2 yl)acridone 4 carboxamide n (pyridin 4yl)acridone 4 carboxamide n cyclopropyl acridone 2 thioacetic acid n cyclopropyl acridone derivative nevirapine s deoxydihydroglyparvin temacrazine unclassified drug unindexed drug zidovudine antiviral activity article Bovine diarrhea virus chemical reaction cyclization cytotoxicity Dengue virus DNA virus drug mechanism drug structure drug synthesis drug targeting enzyme inhibition Hepatitis C virus Herpes simplex virus 1 Herpes simplex virus 2 Human adenovirus Human cytomegalovirus Human immunodeficiency virus 1 Junin virus Lymphocytic choriomeningitis virus nonhuman substitution reaction virus replication Acridones Animals Antiviral Agents DNA Virus Infections DNA Viruses Humans RNA Virus Infections RNA Viruses Sepúlveda, Claudia Soledad Fascio, Mirta Liliana García, Cybele Carina D'Accorso, Norma Beatriz Damonte, Elsa Beatriz Acridones as antiviral agents: Synthesis, chemical and biological properties |
| topic_facet |
Acridones Antiviral activity Arenavirus Cellular target Flavivirus Herpes simplex virus 1 hydroxy 10 methyl 9(10h) acridone 1,3 dihydroxy 5 methoxyacridone 10 allyl 6 chloro 4 methoxy 9(10h) acridone 10 allyl 6 chloro 9(10h) acridone 2 fluoro 5 methoxy n (pyridine 3 yl)acridone 4 carboxamide 3 allyloxy 7 methoxy 1 hydroxyacridone 3,7 dimethoxy 1 hydroxyacridone 5 chloro 1,3 dihydroxyacridone 7 amino 1,3 dihydroxy 10 methyl 6 [4 (2 pyridinyl) 1 piperazinyl] 9(10h) acridone 7 amino 1,3 dimethoxy 10 methyl 6 [4 (4 thiazol) 1 piperazinyl] 9(10h) acridone 7 chloro 1,3 dihydroxyacridone 7 nitro 6 chloro 1,3 dimethoxy 10 methyl 9(10h) acridone aciclovir acridone derivative antivirus agent citrusinine 1 cridanimod cycloferon didanosine glycofolinine n (3 methyl 2 butenyl) 9(10h) acridone derivative n (pyridin 2 yl)acridone 4 carboxamide n (pyridin 4yl)acridone 4 carboxamide n cyclopropyl acridone 2 thioacetic acid n cyclopropyl acridone derivative nevirapine s deoxydihydroglyparvin temacrazine unclassified drug unindexed drug zidovudine antiviral activity article Bovine diarrhea virus chemical reaction cyclization cytotoxicity Dengue virus DNA virus drug mechanism drug structure drug synthesis drug targeting enzyme inhibition Hepatitis C virus Herpes simplex virus 1 Herpes simplex virus 2 Human adenovirus Human cytomegalovirus Human immunodeficiency virus 1 Junin virus Lymphocytic choriomeningitis virus nonhuman substitution reaction virus replication Acridones Animals Antiviral Agents DNA Virus Infections DNA Viruses Humans RNA Virus Infections RNA Viruses |
| description |
Acridones are a class of compounds that have attracted attention in recent years for their wide range of biological properties, including selective inhibition of diverse human pathogenic viruses. The wide spectrum of antiviral activity includes DNA and RNA viruses, such as herpes simplex virus, cytomegalovirus, adenovirus, hepatitis C virus, dengue virus, and Junin virus, among others, indicative of the involvement of cellular factors as potential targets of acridone derivatives. At the present, their precise mode of action is not clearly determined, although the predominant action seems to be centered on the synthesis of nucleic acids. Regarding this point, inhibitory activity against cellular and viral enzymes and the ability to intercalate into nucleic acid molecules was demonstrated for some acridone compounds. Then, the possibility of a multiple effect on different targets renewed interest in these agents for virus chemotherapy allowing a potent inhibitory effectiveness associated to less feasibility of generating antiviral resistance. This review summarizes the current knowledge regarding the methods of synthesis, the antiviral properties of acridone derivatives, their mechanism of action, and structural characteristics related to antiviral activity as well as the perspectives of this class of compounds for clinical application against human viral infections. © 2013 Bentham Science Publishers. |
| author |
Sepúlveda, Claudia Soledad Fascio, Mirta Liliana García, Cybele Carina D'Accorso, Norma Beatriz Damonte, Elsa Beatriz |
| author_facet |
Sepúlveda, Claudia Soledad Fascio, Mirta Liliana García, Cybele Carina D'Accorso, Norma Beatriz Damonte, Elsa Beatriz |
| author_sort |
Sepúlveda, Claudia Soledad |
| title |
Acridones as antiviral agents: Synthesis, chemical and biological properties |
| title_short |
Acridones as antiviral agents: Synthesis, chemical and biological properties |
| title_full |
Acridones as antiviral agents: Synthesis, chemical and biological properties |
| title_fullStr |
Acridones as antiviral agents: Synthesis, chemical and biological properties |
| title_full_unstemmed |
Acridones as antiviral agents: Synthesis, chemical and biological properties |
| title_sort |
acridones as antiviral agents: synthesis, chemical and biological properties |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v20_n19_p2402_Sepulveda http://hdl.handle.net/20.500.12110/paper_09298673_v20_n19_p2402_Sepulveda |
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