A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs
Poly(vinyl alcohol) (PVA) is a hydrophilic, biocompatible and nontoxic polymer. However, because of its low water-resistance, some applications for PVA-based materials are limited (e.g., drug delivery systems and wound dressings). In the current work, PVA mats containing tetracycline hydrochloride (...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284931_v69_n_p726_LopezCordoba http://hdl.handle.net/20.500.12110/paper_09284931_v69_n_p726_LopezCordoba |
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paper:paper_09284931_v69_n_p726_LopezCordoba2023-06-08T15:52:19Z A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs Castro, Guillermo Raúl Goyanes, Silvia Nair Electrospinning Nanofibers Poly(vinyl alcohol) Tetracycline hydrochloride Water-insoluble mats Bacteria Biocompatibility Biomaterials Electrospinning Escherichia coli Nanofibers Spinning (fibers) System stability Textile blends Anti-microbial activity Chemical interactions Drug delivery system Electrical conductivity Laser scanning confocal microscopy Poly (vinyl alcohol) (PVA) Staphylococcus aureus Tetracycline hydrochloride Polyvinyl alcohols antiinfective agent citric acid drug carrier polyvinyl alcohol tetracycline water chemistry drug release green chemistry heat infrared spectroscopy kinetics microbial sensitivity test procedures scanning electron microscopy solubility standard thermogravimetry tissue scaffold ultraviolet spectrophotometry Anti-Bacterial Agents Citric Acid Drug Carriers Drug Liberation Green Chemistry Technology Hot Temperature Kinetics Microbial Sensitivity Tests Microscopy, Electron, Scanning Polyvinyl Alcohol Reference Standards Solubility Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tetracycline Thermogravimetry Tissue Scaffolds Water Poly(vinyl alcohol) (PVA) is a hydrophilic, biocompatible and nontoxic polymer. However, because of its low water-resistance, some applications for PVA-based materials are limited (e.g., drug delivery systems and wound dressings). In the current work, PVA mats containing tetracycline hydrochloride (TC) were successfully developed by electrospinning. In order to improve the water stability of the systems, the cross-linking of the PVA matrix was induced by citric acid (CA) addition together with heating treatments (150 °C or 190 °C for 3 min). TC presence led to a strong increase in the electrical conductivity of the blends and as a result, fibers with about 44% lower diameter (270 nm) than that of the corresponding unloaded mats (485 nm) were obtained. Laser scanning confocal microscopy images indicated that TC was well distributed along the PVA nanofibers. The mats were evaluated by FTIR, which revealed chemical interactions between PVA hydroxyl groups and CA carboxylic ones. The treatment at 150 °C for 3 min proved to be the more suitable for the preparation of TC-containing mats with improved water resistance, maintaining the TC antimicrobial activity against both Escherichia coli and Staphylococcus aureus almost unaltered. These mats showed a burst release of TC, giving around 95% of the drug within the first hour of immersion in water. © 2016 Elsevier B.V. Fil:Castro, G.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Goyanes, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284931_v69_n_p726_LopezCordoba http://hdl.handle.net/20.500.12110/paper_09284931_v69_n_p726_LopezCordoba |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Electrospinning Nanofibers Poly(vinyl alcohol) Tetracycline hydrochloride Water-insoluble mats Bacteria Biocompatibility Biomaterials Electrospinning Escherichia coli Nanofibers Spinning (fibers) System stability Textile blends Anti-microbial activity Chemical interactions Drug delivery system Electrical conductivity Laser scanning confocal microscopy Poly (vinyl alcohol) (PVA) Staphylococcus aureus Tetracycline hydrochloride Polyvinyl alcohols antiinfective agent citric acid drug carrier polyvinyl alcohol tetracycline water chemistry drug release green chemistry heat infrared spectroscopy kinetics microbial sensitivity test procedures scanning electron microscopy solubility standard thermogravimetry tissue scaffold ultraviolet spectrophotometry Anti-Bacterial Agents Citric Acid Drug Carriers Drug Liberation Green Chemistry Technology Hot Temperature Kinetics Microbial Sensitivity Tests Microscopy, Electron, Scanning Polyvinyl Alcohol Reference Standards Solubility Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tetracycline Thermogravimetry Tissue Scaffolds Water |
| spellingShingle |
Electrospinning Nanofibers Poly(vinyl alcohol) Tetracycline hydrochloride Water-insoluble mats Bacteria Biocompatibility Biomaterials Electrospinning Escherichia coli Nanofibers Spinning (fibers) System stability Textile blends Anti-microbial activity Chemical interactions Drug delivery system Electrical conductivity Laser scanning confocal microscopy Poly (vinyl alcohol) (PVA) Staphylococcus aureus Tetracycline hydrochloride Polyvinyl alcohols antiinfective agent citric acid drug carrier polyvinyl alcohol tetracycline water chemistry drug release green chemistry heat infrared spectroscopy kinetics microbial sensitivity test procedures scanning electron microscopy solubility standard thermogravimetry tissue scaffold ultraviolet spectrophotometry Anti-Bacterial Agents Citric Acid Drug Carriers Drug Liberation Green Chemistry Technology Hot Temperature Kinetics Microbial Sensitivity Tests Microscopy, Electron, Scanning Polyvinyl Alcohol Reference Standards Solubility Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tetracycline Thermogravimetry Tissue Scaffolds Water Castro, Guillermo Raúl Goyanes, Silvia Nair A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| topic_facet |
Electrospinning Nanofibers Poly(vinyl alcohol) Tetracycline hydrochloride Water-insoluble mats Bacteria Biocompatibility Biomaterials Electrospinning Escherichia coli Nanofibers Spinning (fibers) System stability Textile blends Anti-microbial activity Chemical interactions Drug delivery system Electrical conductivity Laser scanning confocal microscopy Poly (vinyl alcohol) (PVA) Staphylococcus aureus Tetracycline hydrochloride Polyvinyl alcohols antiinfective agent citric acid drug carrier polyvinyl alcohol tetracycline water chemistry drug release green chemistry heat infrared spectroscopy kinetics microbial sensitivity test procedures scanning electron microscopy solubility standard thermogravimetry tissue scaffold ultraviolet spectrophotometry Anti-Bacterial Agents Citric Acid Drug Carriers Drug Liberation Green Chemistry Technology Hot Temperature Kinetics Microbial Sensitivity Tests Microscopy, Electron, Scanning Polyvinyl Alcohol Reference Standards Solubility Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Tetracycline Thermogravimetry Tissue Scaffolds Water |
| description |
Poly(vinyl alcohol) (PVA) is a hydrophilic, biocompatible and nontoxic polymer. However, because of its low water-resistance, some applications for PVA-based materials are limited (e.g., drug delivery systems and wound dressings). In the current work, PVA mats containing tetracycline hydrochloride (TC) were successfully developed by electrospinning. In order to improve the water stability of the systems, the cross-linking of the PVA matrix was induced by citric acid (CA) addition together with heating treatments (150 °C or 190 °C for 3 min). TC presence led to a strong increase in the electrical conductivity of the blends and as a result, fibers with about 44% lower diameter (270 nm) than that of the corresponding unloaded mats (485 nm) were obtained. Laser scanning confocal microscopy images indicated that TC was well distributed along the PVA nanofibers. The mats were evaluated by FTIR, which revealed chemical interactions between PVA hydroxyl groups and CA carboxylic ones. The treatment at 150 °C for 3 min proved to be the more suitable for the preparation of TC-containing mats with improved water resistance, maintaining the TC antimicrobial activity against both Escherichia coli and Staphylococcus aureus almost unaltered. These mats showed a burst release of TC, giving around 95% of the drug within the first hour of immersion in water. © 2016 Elsevier B.V. |
| author |
Castro, Guillermo Raúl Goyanes, Silvia Nair |
| author_facet |
Castro, Guillermo Raúl Goyanes, Silvia Nair |
| author_sort |
Castro, Guillermo Raúl |
| title |
A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| title_short |
A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| title_full |
A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| title_fullStr |
A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| title_full_unstemmed |
A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| title_sort |
simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284931_v69_n_p726_LopezCordoba http://hdl.handle.net/20.500.12110/paper_09284931_v69_n_p726_LopezCordoba |
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| _version_ |
1768545425809211392 |