Epigenetic mechanisms and memory strength: A comparative study

Memory consolidation requires de novo mRNA and protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors regulate gene expression by interacting with basal transcription machinery, remodeling chromatin structure and...

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Autores principales:	Federman, Maria Noel, Zalcman, Gisela Patricia, De La Fuente, Veronica, Fustiñana, Maria Sol, Romano, Arturo Gabriel
Publicado:	2014
Materias:	Chromatin modifications Gene expression Histone acetylation Long-term memory Memory persistence butyric acid calcium calmodulin dependent protein kinase II cyclic AMP dependent protein kinase early growth response factor 1 histone histone acetyltransferase histone deacetylase histone H3 immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase transcription factor trichostatin A chromatin assembly and disassembly chromatin structure comparative study crab epigenetics gene expression gene expression regulation genetic conservation histone acetylation histone modification long term memory memory consolidation mouse nonhuman protein interaction protein synthesis recognition reinforcement Review RNA synthesis signal transduction transcription initiation acetylation animal genetic epigenesis human memory metabolism physiology Acetylation Animals Epigenesis, Genetic Epigenomics Histones Humans Memory NF-kappa B
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p278_Federman http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p278_Federman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09284257_v108_n4-6_p278_Federman
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spelling	paper:paper_09284257_v108_n4-6_p278_Federman2023-06-08T15:52:15Z Epigenetic mechanisms and memory strength: A comparative study Federman, Maria Noel Zalcman, Gisela Patricia De La Fuente, Veronica Fustiñana, Maria Sol Romano, Arturo Gabriel Chromatin modifications Gene expression Histone acetylation Long-term memory Memory persistence butyric acid calcium calmodulin dependent protein kinase II cyclic AMP dependent protein kinase early growth response factor 1 histone histone acetyltransferase histone deacetylase histone H3 immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase transcription factor trichostatin A histone immunoglobulin enhancer binding protein chromatin assembly and disassembly chromatin structure comparative study crab epigenetics gene expression gene expression regulation genetic conservation histone acetylation histone modification long term memory memory consolidation mouse nonhuman protein interaction protein synthesis recognition reinforcement Review RNA synthesis signal transduction transcription initiation acetylation animal genetic epigenesis human memory metabolism physiology Acetylation Animals Epigenesis, Genetic Epigenomics Histones Humans Memory NF-kappa B Memory consolidation requires de novo mRNA and protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors regulate gene expression by interacting with basal transcription machinery, remodeling chromatin structure and/or chemically modifying histones. Acetylation is the most studied epigenetic mechanism of histones modification. s related to gene expression. This process is regulated by histone acetylases (HATs) and histone deacetylases (HDACs). More than 5. years ago, we began a line of research about the role of histone acetylation during memory consolidation. Here we review our work, presenting evidence about the critical role of this epigenetic mechanism during consolidation of context-signal memory in the crab Neohelice granulata, as well as during consolidation of novel object recognition memory in the mouse Mus musculus. Our evidence demonstrates that histone acetylation is a key mechanism in memory consolidation, functioning as a distinctive molecular feature of strong memories. Furthermore, we found that the strength of a memory can be characterized by its persistence or its resistance to extinction. Besides, we found that the role of this epigenetic mechanism regulating gene expression only in the formation of strongest memories is evolutionarily conserved. © 2014 Elsevier Ltd. Fil:Federman, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Zalcman, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de la Fuente, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fustiñana, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p278_Federman http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p278_Federman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chromatin modifications Gene expression Histone acetylation Long-term memory Memory persistence butyric acid calcium calmodulin dependent protein kinase II cyclic AMP dependent protein kinase early growth response factor 1 histone histone acetyltransferase histone deacetylase histone H3 immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase transcription factor trichostatin A histone immunoglobulin enhancer binding protein chromatin assembly and disassembly chromatin structure comparative study crab epigenetics gene expression gene expression regulation genetic conservation histone acetylation histone modification long term memory memory consolidation mouse nonhuman protein interaction protein synthesis recognition reinforcement Review RNA synthesis signal transduction transcription initiation acetylation animal genetic epigenesis human memory metabolism physiology Acetylation Animals Epigenesis, Genetic Epigenomics Histones Humans Memory NF-kappa B
spellingShingle	Chromatin modifications Gene expression Histone acetylation Long-term memory Memory persistence butyric acid calcium calmodulin dependent protein kinase II cyclic AMP dependent protein kinase early growth response factor 1 histone histone acetyltransferase histone deacetylase histone H3 immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase transcription factor trichostatin A histone immunoglobulin enhancer binding protein chromatin assembly and disassembly chromatin structure comparative study crab epigenetics gene expression gene expression regulation genetic conservation histone acetylation histone modification long term memory memory consolidation mouse nonhuman protein interaction protein synthesis recognition reinforcement Review RNA synthesis signal transduction transcription initiation acetylation animal genetic epigenesis human memory metabolism physiology Acetylation Animals Epigenesis, Genetic Epigenomics Histones Humans Memory NF-kappa B Federman, Maria Noel Zalcman, Gisela Patricia De La Fuente, Veronica Fustiñana, Maria Sol Romano, Arturo Gabriel Epigenetic mechanisms and memory strength: A comparative study
topic_facet	Chromatin modifications Gene expression Histone acetylation Long-term memory Memory persistence butyric acid calcium calmodulin dependent protein kinase II cyclic AMP dependent protein kinase early growth response factor 1 histone histone acetyltransferase histone deacetylase histone H3 immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase transcription factor trichostatin A histone immunoglobulin enhancer binding protein chromatin assembly and disassembly chromatin structure comparative study crab epigenetics gene expression gene expression regulation genetic conservation histone acetylation histone modification long term memory memory consolidation mouse nonhuman protein interaction protein synthesis recognition reinforcement Review RNA synthesis signal transduction transcription initiation acetylation animal genetic epigenesis human memory metabolism physiology Acetylation Animals Epigenesis, Genetic Epigenomics Histones Humans Memory NF-kappa B
description	Memory consolidation requires de novo mRNA and protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors regulate gene expression by interacting with basal transcription machinery, remodeling chromatin structure and/or chemically modifying histones. Acetylation is the most studied epigenetic mechanism of histones modification. s related to gene expression. This process is regulated by histone acetylases (HATs) and histone deacetylases (HDACs). More than 5. years ago, we began a line of research about the role of histone acetylation during memory consolidation. Here we review our work, presenting evidence about the critical role of this epigenetic mechanism during consolidation of context-signal memory in the crab Neohelice granulata, as well as during consolidation of novel object recognition memory in the mouse Mus musculus. Our evidence demonstrates that histone acetylation is a key mechanism in memory consolidation, functioning as a distinctive molecular feature of strong memories. Furthermore, we found that the strength of a memory can be characterized by its persistence or its resistance to extinction. Besides, we found that the role of this epigenetic mechanism regulating gene expression only in the formation of strongest memories is evolutionarily conserved. © 2014 Elsevier Ltd.
author	Federman, Maria Noel Zalcman, Gisela Patricia De La Fuente, Veronica Fustiñana, Maria Sol Romano, Arturo Gabriel
author_facet	Federman, Maria Noel Zalcman, Gisela Patricia De La Fuente, Veronica Fustiñana, Maria Sol Romano, Arturo Gabriel
author_sort	Federman, Maria Noel
title	Epigenetic mechanisms and memory strength: A comparative study
title_short	Epigenetic mechanisms and memory strength: A comparative study
title_full	Epigenetic mechanisms and memory strength: A comparative study
title_fullStr	Epigenetic mechanisms and memory strength: A comparative study
title_full_unstemmed	Epigenetic mechanisms and memory strength: A comparative study
title_sort	epigenetic mechanisms and memory strength: a comparative study
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p278_Federman http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p278_Federman
work_keys_str_mv	AT federmanmarianoel epigeneticmechanismsandmemorystrengthacomparativestudy AT zalcmangiselapatricia epigeneticmechanismsandmemorystrengthacomparativestudy AT delafuenteveronica epigeneticmechanismsandmemorystrengthacomparativestudy AT fustinanamariasol epigeneticmechanismsandmemorystrengthacomparativestudy AT romanoarturogabriel epigeneticmechanismsandmemorystrengthacomparativestudy
_version_	1768541944644894720

Epigenetic mechanisms and memory strength: A comparative study

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