Synaptic NF-kappa B pathway in neuronal plasticity and memory

Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcriptio...

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Autores principales:	Salles, Angeles, Romano, Arturo Gabriel, Freudenthal, Ramiro Angel María
Publicado:	2014
Materias:	Learning-induced plasticity Post-translational modifications Receptor clustering Retrograde transport Synaptic NF-kappa B calcium calmodulin dependent protein kinase II cholinergic receptor dynactin dynein adenosine triphosphatase I kappa B I kappa B kinase immunoglobulin enhancer binding protein messenger RNA postsynaptic density protein 95 transcription factor Rel transcription factor RelA cell communication cell nucleus experimental model gene expression regulation human long term memory long term potentiation memory consolidation mouse nerve cell plasticity neuromuscular synapse neuropil nonhuman postsynaptic potential protein function protein localization protein phosphorylation protein transport rat receptor density reinforcement Review synapse synaptogenesis animal memory metabolism physiology Animals Memory Neuronal Plasticity NF-kappa B Synapses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p256_Salles http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p256_Salles
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09284257_v108_n4-6_p256_Salles
record_format	dspace
spelling	paper:paper_09284257_v108_n4-6_p256_Salles2023-06-08T15:52:15Z Synaptic NF-kappa B pathway in neuronal plasticity and memory Salles, Angeles Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Learning-induced plasticity Post-translational modifications Receptor clustering Retrograde transport Synaptic NF-kappa B calcium calmodulin dependent protein kinase II cholinergic receptor dynactin dynein adenosine triphosphatase I kappa B I kappa B kinase immunoglobulin enhancer binding protein messenger RNA postsynaptic density protein 95 transcription factor Rel transcription factor RelA immunoglobulin enhancer binding protein cell communication cell nucleus experimental model gene expression regulation human long term memory long term potentiation memory consolidation mouse nerve cell plasticity neuromuscular synapse neuropil nonhuman postsynaptic potential protein function protein localization protein phosphorylation protein transport rat receptor density reinforcement Review synapse synaptogenesis animal memory metabolism nerve cell plasticity physiology Animals Memory Neuronal Plasticity NF-kappa B Synapses Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcription factor, plus evidence pointing to different functions, is what gave place to two general hypotheses for synaptic NF-kappa B: (a) The transcription factor plays a role in the synapse to nucleus communication, and it is retrogradely transported from polarized localizations to regulate gene expression; (b) The transcription factor modulates the synaptic function locally. Evidence indicates that both mechanisms can operate simultaneously; here we will present different possibilities of these hypotheses that are supported by an increasing amount of data. We pay special attention to the local role of the transcription factor at the synapse, and based in the described evidence from different animal models, we propose several processes in which the transcription factor may change the synaptic strength. © 2014 Elsevier Ltd. Fil:Salles, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p256_Salles http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p256_Salles
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Learning-induced plasticity Post-translational modifications Receptor clustering Retrograde transport Synaptic NF-kappa B calcium calmodulin dependent protein kinase II cholinergic receptor dynactin dynein adenosine triphosphatase I kappa B I kappa B kinase immunoglobulin enhancer binding protein messenger RNA postsynaptic density protein 95 transcription factor Rel transcription factor RelA immunoglobulin enhancer binding protein cell communication cell nucleus experimental model gene expression regulation human long term memory long term potentiation memory consolidation mouse nerve cell plasticity neuromuscular synapse neuropil nonhuman postsynaptic potential protein function protein localization protein phosphorylation protein transport rat receptor density reinforcement Review synapse synaptogenesis animal memory metabolism nerve cell plasticity physiology Animals Memory Neuronal Plasticity NF-kappa B Synapses
spellingShingle	Learning-induced plasticity Post-translational modifications Receptor clustering Retrograde transport Synaptic NF-kappa B calcium calmodulin dependent protein kinase II cholinergic receptor dynactin dynein adenosine triphosphatase I kappa B I kappa B kinase immunoglobulin enhancer binding protein messenger RNA postsynaptic density protein 95 transcription factor Rel transcription factor RelA immunoglobulin enhancer binding protein cell communication cell nucleus experimental model gene expression regulation human long term memory long term potentiation memory consolidation mouse nerve cell plasticity neuromuscular synapse neuropil nonhuman postsynaptic potential protein function protein localization protein phosphorylation protein transport rat receptor density reinforcement Review synapse synaptogenesis animal memory metabolism nerve cell plasticity physiology Animals Memory Neuronal Plasticity NF-kappa B Synapses Salles, Angeles Romano, Arturo Gabriel Freudenthal, Ramiro Angel María Synaptic NF-kappa B pathway in neuronal plasticity and memory
topic_facet	Learning-induced plasticity Post-translational modifications Receptor clustering Retrograde transport Synaptic NF-kappa B calcium calmodulin dependent protein kinase II cholinergic receptor dynactin dynein adenosine triphosphatase I kappa B I kappa B kinase immunoglobulin enhancer binding protein messenger RNA postsynaptic density protein 95 transcription factor Rel transcription factor RelA immunoglobulin enhancer binding protein cell communication cell nucleus experimental model gene expression regulation human long term memory long term potentiation memory consolidation mouse nerve cell plasticity neuromuscular synapse neuropil nonhuman postsynaptic potential protein function protein localization protein phosphorylation protein transport rat receptor density reinforcement Review synapse synaptogenesis animal memory metabolism nerve cell plasticity physiology Animals Memory Neuronal Plasticity NF-kappa B Synapses
description	Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcription factor, plus evidence pointing to different functions, is what gave place to two general hypotheses for synaptic NF-kappa B: (a) The transcription factor plays a role in the synapse to nucleus communication, and it is retrogradely transported from polarized localizations to regulate gene expression; (b) The transcription factor modulates the synaptic function locally. Evidence indicates that both mechanisms can operate simultaneously; here we will present different possibilities of these hypotheses that are supported by an increasing amount of data. We pay special attention to the local role of the transcription factor at the synapse, and based in the described evidence from different animal models, we propose several processes in which the transcription factor may change the synaptic strength. © 2014 Elsevier Ltd.
author	Salles, Angeles Romano, Arturo Gabriel Freudenthal, Ramiro Angel María
author_facet	Salles, Angeles Romano, Arturo Gabriel Freudenthal, Ramiro Angel María
author_sort	Salles, Angeles
title	Synaptic NF-kappa B pathway in neuronal plasticity and memory
title_short	Synaptic NF-kappa B pathway in neuronal plasticity and memory
title_full	Synaptic NF-kappa B pathway in neuronal plasticity and memory
title_fullStr	Synaptic NF-kappa B pathway in neuronal plasticity and memory
title_full_unstemmed	Synaptic NF-kappa B pathway in neuronal plasticity and memory
title_sort	synaptic nf-kappa b pathway in neuronal plasticity and memory
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p256_Salles http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p256_Salles
work_keys_str_mv	AT sallesangeles synapticnfkappabpathwayinneuronalplasticityandmemory AT romanoarturogabriel synapticnfkappabpathwayinneuronalplasticityandmemory AT freudenthalramiroangelmaria synapticnfkappabpathwayinneuronalplasticityandmemory
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Synaptic NF-kappa B pathway in neuronal plasticity and memory

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