Recurrent inhibition in motor systems, a comparative analysis
The review proposes a comparison between recurrent inhibition in motor systems of vertebrates and the leech nervous system, where a detailed cellular and functional analysis has been accomplished. A comparative study shows that recurrent inhibition is a conserved property in motor systems of phyloge...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n2-3_p148_Szczupak http://hdl.handle.net/20.500.12110/paper_09284257_v108_n2-3_p148_Szczupak |
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paper:paper_09284257_v108_n2-3_p148_Szczupak2023-06-08T15:52:14Z Recurrent inhibition in motor systems, a comparative analysis Szczupak, Lidia Electrical coupling Leech Motor control Nonspiking neuron Recurrent inhibition chemical synapse comparative study electrical coupling electrical synapse leech motoneuron motor performance motor system nerve cell nerve cell inhibition nerve cell membrane potential nervous system electrophysiology neuromodulation nonhuman nonspiking neuron oscillatory potential recurrent inhibition Renshaw cell Review spinal cord synapse synaptic potential vertebrate animal efferent nerve electrophysiology phylogeny physiology Animals Efferent Pathways Electrophysiological Processes Leeches Motor Neurons Neural Inhibition Phylogeny Synapses The review proposes a comparison between recurrent inhibition in motor systems of vertebrates and the leech nervous system, where a detailed cellular and functional analysis has been accomplished. A comparative study shows that recurrent inhibition is a conserved property in motor systems of phylogenetically distant species. Recurrent inhibition has been extensively characterized in the spinal cord of mammals, where Renshaw cells receive excitatory synaptic inputs from motoneurons (MNs) and, in turn, exert an inhibitory effect on the MNs. In the leech, a recurrent inhibitory circuit has been described, centered around a pair of nonspiking (NS) neurons. NS are linked to every excitatory MN through rectifying electrical junctions. And, in addition, the MNs are linked to the NS neurons through hyperpolarizing chemical synapses. Functional analysis of this leech circuit showed that heteronymous MNs in the leech are electrically coupled and this coupling is modulated by the membrane potential of NS neurons. Like Renshaw cells, the membrane potential of NS neurons oscillates in phase with rhythmic motor patterns. Functional analysis performed in the leech shows that NS influences the activity of MNs in the course of crawling suggesting that the recurrent inhibitory circuit modulates the motor performance. © 2014. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n2-3_p148_Szczupak http://hdl.handle.net/20.500.12110/paper_09284257_v108_n2-3_p148_Szczupak |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Electrical coupling Leech Motor control Nonspiking neuron Recurrent inhibition chemical synapse comparative study electrical coupling electrical synapse leech motoneuron motor performance motor system nerve cell nerve cell inhibition nerve cell membrane potential nervous system electrophysiology neuromodulation nonhuman nonspiking neuron oscillatory potential recurrent inhibition Renshaw cell Review spinal cord synapse synaptic potential vertebrate animal efferent nerve electrophysiology phylogeny physiology Animals Efferent Pathways Electrophysiological Processes Leeches Motor Neurons Neural Inhibition Phylogeny Synapses |
| spellingShingle |
Electrical coupling Leech Motor control Nonspiking neuron Recurrent inhibition chemical synapse comparative study electrical coupling electrical synapse leech motoneuron motor performance motor system nerve cell nerve cell inhibition nerve cell membrane potential nervous system electrophysiology neuromodulation nonhuman nonspiking neuron oscillatory potential recurrent inhibition Renshaw cell Review spinal cord synapse synaptic potential vertebrate animal efferent nerve electrophysiology phylogeny physiology Animals Efferent Pathways Electrophysiological Processes Leeches Motor Neurons Neural Inhibition Phylogeny Synapses Szczupak, Lidia Recurrent inhibition in motor systems, a comparative analysis |
| topic_facet |
Electrical coupling Leech Motor control Nonspiking neuron Recurrent inhibition chemical synapse comparative study electrical coupling electrical synapse leech motoneuron motor performance motor system nerve cell nerve cell inhibition nerve cell membrane potential nervous system electrophysiology neuromodulation nonhuman nonspiking neuron oscillatory potential recurrent inhibition Renshaw cell Review spinal cord synapse synaptic potential vertebrate animal efferent nerve electrophysiology phylogeny physiology Animals Efferent Pathways Electrophysiological Processes Leeches Motor Neurons Neural Inhibition Phylogeny Synapses |
| description |
The review proposes a comparison between recurrent inhibition in motor systems of vertebrates and the leech nervous system, where a detailed cellular and functional analysis has been accomplished. A comparative study shows that recurrent inhibition is a conserved property in motor systems of phylogenetically distant species. Recurrent inhibition has been extensively characterized in the spinal cord of mammals, where Renshaw cells receive excitatory synaptic inputs from motoneurons (MNs) and, in turn, exert an inhibitory effect on the MNs. In the leech, a recurrent inhibitory circuit has been described, centered around a pair of nonspiking (NS) neurons. NS are linked to every excitatory MN through rectifying electrical junctions. And, in addition, the MNs are linked to the NS neurons through hyperpolarizing chemical synapses. Functional analysis of this leech circuit showed that heteronymous MNs in the leech are electrically coupled and this coupling is modulated by the membrane potential of NS neurons. Like Renshaw cells, the membrane potential of NS neurons oscillates in phase with rhythmic motor patterns. Functional analysis performed in the leech shows that NS influences the activity of MNs in the course of crawling suggesting that the recurrent inhibitory circuit modulates the motor performance. © 2014. |
| author |
Szczupak, Lidia |
| author_facet |
Szczupak, Lidia |
| author_sort |
Szczupak, Lidia |
| title |
Recurrent inhibition in motor systems, a comparative analysis |
| title_short |
Recurrent inhibition in motor systems, a comparative analysis |
| title_full |
Recurrent inhibition in motor systems, a comparative analysis |
| title_fullStr |
Recurrent inhibition in motor systems, a comparative analysis |
| title_full_unstemmed |
Recurrent inhibition in motor systems, a comparative analysis |
| title_sort |
recurrent inhibition in motor systems, a comparative analysis |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n2-3_p148_Szczupak http://hdl.handle.net/20.500.12110/paper_09284257_v108_n2-3_p148_Szczupak |
| work_keys_str_mv |
AT szczupaklidia recurrentinhibitioninmotorsystemsacomparativeanalysis |
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1768543617775828992 |