Rational design of polymer-lipid nanoparticles for docetaxel delivery
In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the...
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2019
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09277765_v175_n_p56_Albano http://hdl.handle.net/20.500.12110/paper_09277765_v175_n_p56_Albano |
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paper:paper_09277765_v175_n_p56_Albano2023-06-08T15:52:05Z Rational design of polymer-lipid nanoparticles for docetaxel delivery Cetyl palmitate Docetaxel Drug delivery system Nanocarrier Poloxamer Rational design Diseases Ethylene Glycoproteins Light scattering Molecular dynamics Nanoparticles Palmitic acid Polymers Targeted drug delivery Cetyl palmitate Docetaxel Drug delivery system Nanocarriers Poloxamer Rational design Controlled drug delivery docetaxel glycoprotein P inhibitor nanocarrier poloxamer polyethylene polymer solid lipid nanoparticle analysis of variance Article body distribution centrifugation chemical phenomena clinical assessment differential scanning calorimetry dispersity drug delivery system drug determination drug formulation drug penetration drug retention drug solubility factor analysis feasibility study Fourier transform infrared spectroscopy high performance liquid chromatography hydrodynamics immune system kinetics melting point molecular dynamics nanoencapsulation particle size photon correlation spectroscopy physical chemistry priority journal rational emotive behavior therapy simulation slow release formulation structure analysis toxicity testing transmission electron microscopy ultrafiltration X ray diffraction zeta potential In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the effects of the polymers in the final composition. In this direction, two poloxoamers -Pluronic F127 and F68- were selected. Some poloxamers are well known to be inhibitors of the P-glycoprotein efflux pump. Additionally, their poly-ethylene-oxide blocks can help them to escape the immune system, making the poloxamers appealing to be present in a nanoparticle designed for the treatment of cancer. Within this context, a factorial experiment design was used to achieve the most suitable formulations, and also to identify the effects of each component on the final (optimized) systems. Two final formulations were chosen with sizes < 250 nm and PDI < 0.2. Then, using dynamic light scattering and nanotracking techniques, the stability of the formulations was assessed during six months. Structural studies were carried on trough different techniques: DSC, x-ray diffraction, FTIR-AR and Molecular Dynamics. The encapsulation efficiency of the anticancer drug docetaxel (> 90%) and its release dynamics from formulations were measured, showing that the polymer-lipid nanoparticle is suitable as a drug delivery system for the treatment of cancer. © 2018 Elsevier B.V. 2019 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09277765_v175_n_p56_Albano http://hdl.handle.net/20.500.12110/paper_09277765_v175_n_p56_Albano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cetyl palmitate Docetaxel Drug delivery system Nanocarrier Poloxamer Rational design Diseases Ethylene Glycoproteins Light scattering Molecular dynamics Nanoparticles Palmitic acid Polymers Targeted drug delivery Cetyl palmitate Docetaxel Drug delivery system Nanocarriers Poloxamer Rational design Controlled drug delivery docetaxel glycoprotein P inhibitor nanocarrier poloxamer polyethylene polymer solid lipid nanoparticle analysis of variance Article body distribution centrifugation chemical phenomena clinical assessment differential scanning calorimetry dispersity drug delivery system drug determination drug formulation drug penetration drug retention drug solubility factor analysis feasibility study Fourier transform infrared spectroscopy high performance liquid chromatography hydrodynamics immune system kinetics melting point molecular dynamics nanoencapsulation particle size photon correlation spectroscopy physical chemistry priority journal rational emotive behavior therapy simulation slow release formulation structure analysis toxicity testing transmission electron microscopy ultrafiltration X ray diffraction zeta potential |
| spellingShingle |
Cetyl palmitate Docetaxel Drug delivery system Nanocarrier Poloxamer Rational design Diseases Ethylene Glycoproteins Light scattering Molecular dynamics Nanoparticles Palmitic acid Polymers Targeted drug delivery Cetyl palmitate Docetaxel Drug delivery system Nanocarriers Poloxamer Rational design Controlled drug delivery docetaxel glycoprotein P inhibitor nanocarrier poloxamer polyethylene polymer solid lipid nanoparticle analysis of variance Article body distribution centrifugation chemical phenomena clinical assessment differential scanning calorimetry dispersity drug delivery system drug determination drug formulation drug penetration drug retention drug solubility factor analysis feasibility study Fourier transform infrared spectroscopy high performance liquid chromatography hydrodynamics immune system kinetics melting point molecular dynamics nanoencapsulation particle size photon correlation spectroscopy physical chemistry priority journal rational emotive behavior therapy simulation slow release formulation structure analysis toxicity testing transmission electron microscopy ultrafiltration X ray diffraction zeta potential Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| topic_facet |
Cetyl palmitate Docetaxel Drug delivery system Nanocarrier Poloxamer Rational design Diseases Ethylene Glycoproteins Light scattering Molecular dynamics Nanoparticles Palmitic acid Polymers Targeted drug delivery Cetyl palmitate Docetaxel Drug delivery system Nanocarriers Poloxamer Rational design Controlled drug delivery docetaxel glycoprotein P inhibitor nanocarrier poloxamer polyethylene polymer solid lipid nanoparticle analysis of variance Article body distribution centrifugation chemical phenomena clinical assessment differential scanning calorimetry dispersity drug delivery system drug determination drug formulation drug penetration drug retention drug solubility factor analysis feasibility study Fourier transform infrared spectroscopy high performance liquid chromatography hydrodynamics immune system kinetics melting point molecular dynamics nanoencapsulation particle size photon correlation spectroscopy physical chemistry priority journal rational emotive behavior therapy simulation slow release formulation structure analysis toxicity testing transmission electron microscopy ultrafiltration X ray diffraction zeta potential |
| description |
In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the effects of the polymers in the final composition. In this direction, two poloxoamers -Pluronic F127 and F68- were selected. Some poloxamers are well known to be inhibitors of the P-glycoprotein efflux pump. Additionally, their poly-ethylene-oxide blocks can help them to escape the immune system, making the poloxamers appealing to be present in a nanoparticle designed for the treatment of cancer. Within this context, a factorial experiment design was used to achieve the most suitable formulations, and also to identify the effects of each component on the final (optimized) systems. Two final formulations were chosen with sizes < 250 nm and PDI < 0.2. Then, using dynamic light scattering and nanotracking techniques, the stability of the formulations was assessed during six months. Structural studies were carried on trough different techniques: DSC, x-ray diffraction, FTIR-AR and Molecular Dynamics. The encapsulation efficiency of the anticancer drug docetaxel (> 90%) and its release dynamics from formulations were measured, showing that the polymer-lipid nanoparticle is suitable as a drug delivery system for the treatment of cancer. © 2018 Elsevier B.V. |
| title |
Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| title_short |
Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| title_full |
Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| title_fullStr |
Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| title_full_unstemmed |
Rational design of polymer-lipid nanoparticles for docetaxel delivery |
| title_sort |
rational design of polymer-lipid nanoparticles for docetaxel delivery |
| publishDate |
2019 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09277765_v175_n_p56_Albano http://hdl.handle.net/20.500.12110/paper_09277765_v175_n_p56_Albano |
| _version_ |
1768544233059254272 |