Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro

The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is...

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Autores principales:	Wachsman, Mónica Beatriz, Castilla, Viviana, Talarico, Laura Beatriz, Ramirez, Javier Alberto, Coto, Celia Esther
Publicado:	2004
Materias:	(22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one Antiviral Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one antivirus agent brassinosteroid unclassified drug animal cell antigen expression article controlled study drug mechanism Herpes simplex virus 1 immunofluorescence test in vitro study nonhuman priority journal protein synthesis Vero cell virus replication Animals Antigens, Viral Antiviral Agents Cercopithecus aethiops Cholestanones Fluorescent Antibody Technique, Indirect Herpesvirus 1, Human Transcription, Genetic Vero Cells Viral Proteins Virus Replication
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n5_p524_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v23_n5_p524_Wachsman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09248579_v23_n5_p524_Wachsman
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spelling	paper:paper_09248579_v23_n5_p524_Wachsman2023-06-08T15:51:10Z Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro Wachsman, Mónica Beatriz Castilla, Viviana Talarico, Laura Beatriz Ramirez, Javier Alberto Coto, Celia Esther (22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one Antiviral Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one antivirus agent brassinosteroid unclassified drug animal cell antigen expression article controlled study drug mechanism Herpes simplex virus 1 immunofluorescence test in vitro study nonhuman priority journal protein synthesis Vero cell virus replication Animals Antigens, Viral Antiviral Agents Cercopithecus aethiops Cholestanones Fluorescent Antibody Technique, Indirect Herpesvirus 1, Human Transcription, Genetic Vero Cells Viral Proteins Virus Replication The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. Fil:Wachsman, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Talarico, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramirez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n5_p524_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v23_n5_p524_Wachsman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	(22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one Antiviral Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one antivirus agent brassinosteroid unclassified drug animal cell antigen expression article controlled study drug mechanism Herpes simplex virus 1 immunofluorescence test in vitro study nonhuman priority journal protein synthesis Vero cell virus replication Animals Antigens, Viral Antiviral Agents Cercopithecus aethiops Cholestanones Fluorescent Antibody Technique, Indirect Herpesvirus 1, Human Transcription, Genetic Vero Cells Viral Proteins Virus Replication
spellingShingle	(22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one Antiviral Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one antivirus agent brassinosteroid unclassified drug animal cell antigen expression article controlled study drug mechanism Herpes simplex virus 1 immunofluorescence test in vitro study nonhuman priority journal protein synthesis Vero cell virus replication Animals Antigens, Viral Antiviral Agents Cercopithecus aethiops Cholestanones Fluorescent Antibody Technique, Indirect Herpesvirus 1, Human Transcription, Genetic Vero Cells Viral Proteins Virus Replication Wachsman, Mónica Beatriz Castilla, Viviana Talarico, Laura Beatriz Ramirez, Javier Alberto Coto, Celia Esther Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
topic_facet	(22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one Antiviral Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one antivirus agent brassinosteroid unclassified drug animal cell antigen expression article controlled study drug mechanism Herpes simplex virus 1 immunofluorescence test in vitro study nonhuman priority journal protein synthesis Vero cell virus replication Animals Antigens, Viral Antiviral Agents Cercopithecus aethiops Cholestanones Fluorescent Antibody Technique, Indirect Herpesvirus 1, Human Transcription, Genetic Vero Cells Viral Proteins Virus Replication
description	The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
author	Wachsman, Mónica Beatriz Castilla, Viviana Talarico, Laura Beatriz Ramirez, Javier Alberto Coto, Celia Esther
author_facet	Wachsman, Mónica Beatriz Castilla, Viviana Talarico, Laura Beatriz Ramirez, Javier Alberto Coto, Celia Esther
author_sort	Wachsman, Mónica Beatriz
title	Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
title_short	Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
title_full	Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
title_fullStr	Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
title_full_unstemmed	Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
title_sort	antiherpetic mode of action of (22s,23s)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n5_p524_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v23_n5_p524_Wachsman
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Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro

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