Antiviral activity of enterocin CRL35 against herpesviruses
Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v12_n4_p293_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v12_n4_p293_Wachsman |
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| Sumario: | Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 μg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected. Copyright (C) 1999 Elsevier Science B.V. |
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