Antiviral activity of enterocin CRL35 against herpesviruses
Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v12_n4_p293_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v12_n4_p293_Wachsman |
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paper:paper_09248579_v12_n4_p293_Wachsman2023-06-08T15:51:09Z Antiviral activity of enterocin CRL35 against herpesviruses Antiviral Bacteriocin Enterococcus faecium Herpes simplex type 1 and 2 bacteriocin enterocin crl35 polypeptide unclassified drug animal cell antiviral activity article cell strain bhk controlled study cytotoxicity enterococcus faecium hamster herpes simplex virus 1 herpes simplex virus 2 herpes virus monkey nonhuman priority journal vero cell virogenesis Acyclovir Animals Antiviral Agents Bacteriocins Cell Line Cell Survival Cercopithecus aethiops Chromatography, High Pressure Liquid Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Vero Cells Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 μg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected. Copyright (C) 1999 Elsevier Science B.V. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v12_n4_p293_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v12_n4_p293_Wachsman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral Bacteriocin Enterococcus faecium Herpes simplex type 1 and 2 bacteriocin enterocin crl35 polypeptide unclassified drug animal cell antiviral activity article cell strain bhk controlled study cytotoxicity enterococcus faecium hamster herpes simplex virus 1 herpes simplex virus 2 herpes virus monkey nonhuman priority journal vero cell virogenesis Acyclovir Animals Antiviral Agents Bacteriocins Cell Line Cell Survival Cercopithecus aethiops Chromatography, High Pressure Liquid Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Vero Cells |
| spellingShingle |
Antiviral Bacteriocin Enterococcus faecium Herpes simplex type 1 and 2 bacteriocin enterocin crl35 polypeptide unclassified drug animal cell antiviral activity article cell strain bhk controlled study cytotoxicity enterococcus faecium hamster herpes simplex virus 1 herpes simplex virus 2 herpes virus monkey nonhuman priority journal vero cell virogenesis Acyclovir Animals Antiviral Agents Bacteriocins Cell Line Cell Survival Cercopithecus aethiops Chromatography, High Pressure Liquid Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Vero Cells Antiviral activity of enterocin CRL35 against herpesviruses |
| topic_facet |
Antiviral Bacteriocin Enterococcus faecium Herpes simplex type 1 and 2 bacteriocin enterocin crl35 polypeptide unclassified drug animal cell antiviral activity article cell strain bhk controlled study cytotoxicity enterococcus faecium hamster herpes simplex virus 1 herpes simplex virus 2 herpes virus monkey nonhuman priority journal vero cell virogenesis Acyclovir Animals Antiviral Agents Bacteriocins Cell Line Cell Survival Cercopithecus aethiops Chromatography, High Pressure Liquid Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Vero Cells |
| description |
Enterocin CRL35 is an antibacterial polypeptide of 3.5x103 Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 μg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected. Copyright (C) 1999 Elsevier Science B.V. |
| title |
Antiviral activity of enterocin CRL35 against herpesviruses |
| title_short |
Antiviral activity of enterocin CRL35 against herpesviruses |
| title_full |
Antiviral activity of enterocin CRL35 against herpesviruses |
| title_fullStr |
Antiviral activity of enterocin CRL35 against herpesviruses |
| title_full_unstemmed |
Antiviral activity of enterocin CRL35 against herpesviruses |
| title_sort |
antiviral activity of enterocin crl35 against herpesviruses |
| publishDate |
1999 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v12_n4_p293_Wachsman http://hdl.handle.net/20.500.12110/paper_09248579_v12_n4_p293_Wachsman |
| _version_ |
1768544919426695168 |