Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
The chemistry of aqueous NO and H 2 S as redox regulators of cellular and physiological responses in cardiovascular, immune or neurological tissues has raised the question of the overlapping pathophysiological functions often involving similar molecular targets. The interactions of NO with H 2 S may...
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| Autores principales: | , , |
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08988838_v70_n_p277_Marcolongo http://hdl.handle.net/20.500.12110/paper_08988838_v70_n_p277_Marcolongo |
| Aporte de: |
| Sumario: | The chemistry of aqueous NO and H 2 S as redox regulators of cellular and physiological responses in cardiovascular, immune or neurological tissues has raised the question of the overlapping pathophysiological functions often involving similar molecular targets. The interactions of NO with H 2 S may functionally influence each other and focus has been directed to new N/S hybrid species eventually determining signaling capabilities. Besides the well-studied nitrosothiols, RSNOs, the eruption of H 2 S in the mechanistic scene has stimulated increased interest in thionitrous acid, HSNO, and thionitrite, NOS − , as well as in perthionitrite (nitrosopersulfide), S 2 NO − . We discuss the elusive chemistry of the latter molecules as intermediates in selected reactions in aqueous solution, either as free species or as bound to iron metal centers. The coordination chemistry involves mainly an updating on the “Gmelin” reaction proceeding upon mixing nitroprusside [Fe(CN) 5 (NO)] 2 − and H 2 S, with controversial and still unsolved mechanistic issues related to the onset of NO, HNO/N 2 O, polysulfides HS n − (n = 2–7), together with bound thionitrous acid/thionitrite/perthionitrite and other intermediates and products. © 2017 Elsevier Inc. |
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